Molecular allergen profiling in horses by microarray reveals Fag e 2 from buckwheat as a frequent sensitizer

Einhorn, Lukas; Hofstetter, Gerlinde; Brandt, Sabine; Hainisch, Edmund K.; Fukuda, I; Kusano, Kanichi; Scheynius, Annika; Mittermann, Irene; Resch, Yvonne; Vrtala, Susanne; Valenta, Rudolf; Marti, Eliane; Rhyner, Claudio; Crameri, Reto; Satoh, Rie; Teshima, Reiko; Tanaka, Akane; Sato, Hiroaki; Matsuda, Hiroshi; Pali‐Schöll, Isabella; Jensen‐Jarolim, Erika

doi:10.1111/all.13417

Cited by 10 publications

(9 citation statements)

References 81 publications

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“…Because this test can be performed using collected and stored blood samples, it may be a very valuable tool for diagnostics. In a previous study, we customised ImmunoCAP ® ISAC 112 for horses by adding 19 additional allergens and created ImmunoCAP ISAC 131 (Einhorn et al 2018). Using 'ImmunoCAP ® ISAC 131' we succeeded in detecting Fag e 2 as a causative allergen in 70% of investigated horses with allergic symptoms, likely sensitised by special 'protein-rich' horse diets, such as 'horse muesli' (Fig.…”

Section: Buckwheat Allergies In Animalsmentioning

confidence: 99%

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Understanding buckwheat allergies for the management of allergic reactions in humans and animals

2020

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Buckwheat allergy is an immediate hypersensitivity reaction that includes anaphylaxis mediated by specific IgE antibodies. Several IgE-binding proteins in common buckwheat have been reported to be possible clinically relevant buckwheat allergens. Although common buckwheat is popularly consumed in Asia, buckwheat allergy is becoming a serious problem not only in Asia but also in Europe. In addition, common buckwheat has also been found to be a causative agent of allergic symptoms in animals. In recent years, in addition to conventional food allergy testing methods, the development of component-resolved diagnosis (CRD) has improved the diagnostic accuracy of food allergy. The identification of allergens is essential for the construction of CRD. In this review, we introduce the different types of buckwheat allergens and discuss how each buckwheat allergen contributes to the diagnosis of buckwheat allergy. We also present the analysis of buckwheat allergen that will help reduce the allergenicity of common buckwheat and reduce buckwheat allergen molecules. These findings may be beneficial in overcoming buckwheat allergies in humans and animals.

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Section: Buckwheat Allergies In Animalsmentioning

confidence: 99%

“…Common buckwheat is also added to animal feed for the purpose of nutrient addition (Keles et al 2018), and its husk is used as bedding material to add comfort to the animal breeding environment. However, recently, buckwheat allergy has also been reported in horses (Einhorn et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Understanding buckwheat allergies for the management of allergic reactions in humans and animals

2020

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“…While robust data regarding atopy exist in people, the situation in pet and farm animals has been investigated only recently. Dog breeds with a high prevalence of atopic skin disorders include the West Highland white terrier, Boxer, English bulldog, Dalmatian and French bulldog . In a Turkish human cohort, 33% of Hymenoptera reactive patients had atopic diseases, and in a Mexican study on beekeepers with atopic family history, it was 3.9% (CI 1.7‐9.2) .…”

Section: Pathogenesis Of Insect Allergymentioning

confidence: 99%

EAACIposition paper: Comparing insect hypersensitivity induced by bite, sting, inhalation or ingestion in human beings and animals

Pali‐Schöll

Blank

Verhoeckx

et al. 2019

Allergy

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Adverse reactions to insects occur in both human and veterinary patients. Systematic comparison may lead to improved recommendations for prevention and treatment in all species. In this position paper, we summarize the current knowledge on insect allergy induced via stings, bites, inhalation or ingestion, and compare reactions in companion animals to those in people. With few exceptions, the situation in human insect allergy is better documented than in animals. We focus on a review of recent literature and give overviews of the epidemiology and clinical signs.We discuss allergen sources and allergenic molecules to the extent described, and aspects of diagnosis, prophylaxis, management and therapy. K E Y W O R D S allergenic molecules in insects, comparative, insect bite hypersensitivity, insect food allergy, insect venom allergy Abbreviations: BAT, basophil activation test; CCD, cross-reactive carbohydrate determinant; CRD, component-resolved diagnosis; DBPCFC, double-blind placebo-controlled food challenge; FBH, flea bite hypersensitivity; HDM, house dust mite; IBH, insect bite hypersensitivity; IGR, insect growth regulator; LLR, large local reaction; MBH, mosquito bite hypersensitivity; RAST, radioallergosorbent test; VIT, venom immunotherapy.

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“…RAO is a recurring pulmonary disease that typically affects middle-aged horses. It results in coughing and loss of performance (Einhorn et al, 2018). These clinical signs are largely triggered by bronchoconstriction and compromised gas exchange (Herszberg et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Assessment of serum allergenspecific IgE levels in horses from Siedlce County, Poland

Drywulska-Gierasimiuk

Górski

Andraszek

et al. 2020

Vet. stn. (Online)

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The aim of the present study was to determine the frequency of different allergies in horses from central Poland. Allergic diseases are common in horses all over the world. Common conditions that have been associated with immunoglobulin E (IgE)-mediated allergy in horses include insect bite hypersensitivity (IBH), urticaria and recurrent airway obstruction (RAO). A variety of serological assays are available to measure serum levels of allergen-specific IgE antibodies. They can provide supportive evidence for a diagnosis of equine allergic dermatitis associated with environmental allergens. This study was performed on clinically healthy, Polish noble half-breed horses. In this study, four groups of allergens were identified as commonly inducing allergic reactions: American house dust mites (D. farinae), cultivated plants (rape), English plantain (Plantago lanceolata) and biting midges (Culicoides nubeculosus). More than 50% of horses showed positive reactions to these groups of allergens. The factor that contributed most to allergy occurrence among horses was American house dust mites (D. farinae). In recent years, efforts have been made to identify new allergens and to better understand the specific pathogenesis of allergic diseases in animals. The development of allergic disease diagnostics has been facilitated by the availability of diagnostic methods along with enhanced awareness of allergic diseases in veterinary practice. Allergic disorders in horses are ultimately gaining the attention they deserve thanks to the fact that veterinary allergology has become a dedicated veterinary discipline.

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Molecular allergen profiling in horses by microarray reveals Fag e 2 from buckwheat as a frequent sensitizer

Cited by 10 publications

References 81 publications

Understanding buckwheat allergies for the management of allergic reactions in humans and animals

Understanding buckwheat allergies for the management of allergic reactions in humans and animals

EAACIposition paper: Comparing insect hypersensitivity induced by bite, sting, inhalation or ingestion in human beings and animals

Assessment of serum allergenspecific IgE levels in horses from Siedlce County, Poland

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