Plant compounds and nonsteroidal anti-inflammatory drugs interfere with quorum sensing in Chromobacterium violaceum

Vargas, Erika; Almeida, Felipe Alves de; Freitas, Leonardo Luiz de; Pinto, Uelinton Manoel; Vanetti, Maria Cristina Dantas

doi:10.1007/s00203-021-02518-w

Cited by 11 publications

(6 citation statements)

References 57 publications

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“…Previous studies basically focused on determining the acute toxicity of KTP at high concentrations ( Marchlewicz et al, 2017 ; Żur et al, 2018 ; Petrie and Camacho-Muñoz, 2021 ; Praveenkumarreddy et al, 2021 ). For instance, KTP was found to inhibit the quorum sensing of gram-negative pathogens such as Acinetobacter baumannii , Chromobacterium violaceum , and Pseudomonas aeruginosa ( Tajani et al, 2021 ; Vargas et al, 2021 ; Elshaer et al, 2022 ). An intriguing work by Neale et al (2019) aimed to determine the effects of different NSAID enantiomers on the bacterium Photobacterium leiognathi using the Bacterial Luminescence Toxicity Screen.…”

Section: Ecotoxic Effects Of Ketoprofenmentioning

confidence: 99%

Ketoprofen as an emerging contaminant: occurrence, ecotoxicity and (bio)removal

Tyumina,

Subbotina,

Polygalov

et al. 2023

Front. Microbiol.

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Ketoprofen, a bicyclic non-steroidal anti-inflammatory drug commonly used in human and veterinary medicine, has recently been cited as an environmental contaminant that raises concerns for ecological well-being. It poses a growing threat due to its racemic mixture, enantiomers, and transformation products, which have ecotoxicological effects on various organisms, including invertebrates, vertebrates, plants, and microorganisms. Furthermore, ketoprofen is bioaccumulated and biomagnified throughout the food chain, threatening the ecosystem function. Surprisingly, despite these concerns, ketoprofen is not currently considered a priority substance. While targeted eco-pharmacovigilance for ketoprofen has been proposed, data on ketoprofen as a pharmaceutical contaminant are limited and incomplete. This review aims to provide a comprehensive summary of the most recent findings (from 2017 to March 2023) regarding the global distribution of ketoprofen in the environment, its ecotoxicity towards aquatic animals and plants, and available removal methods. Special emphasis is placed on understanding how ketoprofen affects microorganisms that play a pivotal role in Earth’s ecosystems. The review broadly covers various approaches to ketoprofen biodegradation, including whole-cell fungal and bacterial systems as well as enzyme biocatalysts. Additionally, it explores the potential of adsorption by algae and phytoremediation for removing ketoprofen. This review will be of interest to a wide range of readers, including ecologists, microbiologists, policymakers, and those concerned about pharmaceutical pollution.

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Section: Ecotoxic Effects Of Ketoprofenmentioning

confidence: 99%

Ketoprofen as an emerging contaminant: occurrence, ecotoxicity and (bio)removal

Tyumina,

Subbotina,

Polygalov

et al. 2023

Front. Microbiol.

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“…A classic example is the halogenated furanones produced by the Australian red alga ( Delisea pulchra ), which inhibit the QS system of the marine bacterium Serratia liquefaciens [ 49 ] as well as other QS systems in Gram-negative bacteria [ 50 ]. The anti-QS compounds can act at several levels [ 44 , 51 ]: (i) They might prevent the binding of the autoinducer to its receptor (e.g., phytol binds to CviR of Chromobacterium violaceum ) [ 52 ]. (ii) They might inhibit the phosphorelay induced by the autoinducer receptor by either preventing the phosphorylation of downstream mediators or by repressing the expression of the receptor (e.g., cinnamaldehyde represses the expression of LasB, RhlA and PqsA in Pseudomonas aeruginosa ) [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

The Antibacterial Effect of Cannabigerol toward Streptococcus mutans Is Influenced by the Autoinducers 21-CSP and AI-2

et al. 2023

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Bacteria can communicate through an intercellular signaling system referred to as quorum sensing (QS). The QS system involves the production of autoinducers that interact with their respective receptors, leading to the induction of specific signal transduction pathways. The QS systems of the oral cariogenic Streptococcus mutans regulate the maturation of biofilms and affect its virulent properties. We have previously shown that the non-psychoactive compound cannabigerol (CBG) of the Cannabis sativa L. plant has anti-bacterial and anti-biofilm activities towards S. mutans. Here we were interested in investigating the effect of the two QS systems ComCDE and LuxS on the susceptibility of S. mutans to CBG and the anti-QS activities of CBG. This was assessed by using various comCDE and luxS mutant strains and complementation with the respective autoinducers, competence stimulating peptide (CSP) and (S)-4,5-dihydroxy-2,3-pentandione (DPD, pre-AI-2). We found that S. mutans comCDE knockout strains were more sensitive to the anti-bacterial actions of CBG compared to the WT strain. Exogenously added 21-CSP prevented the anti-bacterial actions caused by CBG on the ΔcomC, ΔcomE and ΔluxS mutants, while having no effect on the susceptibility of the WT and ΔcomCDE strains to CBG. Exogenously added DPD increased the susceptibility of WT and ΔluxS to CBG. Vice versa, CBG significantly reduced the 21-CSP-induced expression of comCDE genes and ComE-regulated genes and suppressed the expression of luxS with concomitant reduction in AI-2 production. DPD induced the expression of comCDE genes and ComE-regulated genes, and this induction was repressed by CBG. 21-CSP alone had no significant effect on luxS gene expression, while ΔcomCDE strains showed reduced AI-2 production. In conclusion, our study shows that the susceptibility of S. mutans to CBG is affected by the ComCDE and LuxS QS pathways, and CBG is a potential anti-QS compound for S. mutans. Additionally, we provide evidence for crosstalk between the ComCDE and LuxS QS systems.

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“…The second strategy is to use structural analogs of AHLs to competitively bind QS LuxR‐type receptor proteins, thereby preventing the triggering of the QS system. Many natural substances such as cinnamaldehyde, vanillin, phytol, curcumin, and carvacrol can inhibit bacterial QS in this way, thereby improving the storage quality of various foods, including turbot, chicken, beef, milk, and salmon (Deryabin et al., 2019; Li et al., 2018; Shastry et al., 2022; Vargas et al., 2021). However, recent studies have demonstrated that some of these QS competitive inhibitors, including the typical furanone C30, can be discharged by the bacterial efflux pump system, thus weakening their actual effect (Huang et al., 2022).…”

Section: The Opportunity Of Qq Enzymes In the Food And Related Indust...mentioning

confidence: 99%

Quorum‐quenching enzymes: Promising bioresources and their opportunities and challenges as alternative bacteriostatic agents in food industry

Dangfeng

Cui

Ren

et al. 2023

Comp Rev Food Sci Food Safe

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The problems of spoilage, disease, and biofilm caused by bacterial quorum‐sensing (QS) systems have posed a significant challenge to the development of the food industry. Quorum‐quenching (QQ) enzymes can block QS by hydrolyzing or modifying the signal molecule, making these enzymes promising new candidates for use as antimicrobials. With many recent studies of QQ enzymes and their potential to target foodborne bacteria, an updated and systematic review is necessary. Thus, the goals of this review were to summarize what is known about the effects of bacterial QS on the food industry; discuss the current understanding of the catalytic mechanisms of QQ enzymes, including lactonase, acylase, and oxidoreductase; and describe strategies for the engineering and evolution of QQ enzymes for practical use. In particular, this review focuses on the latest progress in the application of QQ enzymes in the field of food. Finally, the current challenges limiting the systematic application of QQ enzymes in the food industry are discussed to help guide the future development of these important enzymes.

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Plant compounds and nonsteroidal anti-inflammatory drugs interfere with quorum sensing in Chromobacterium violaceum

Cited by 11 publications

References 57 publications

Ketoprofen as an emerging contaminant: occurrence, ecotoxicity and (bio)removal

Ketoprofen as an emerging contaminant: occurrence, ecotoxicity and (bio)removal

The Antibacterial Effect of Cannabigerol toward Streptococcus mutans Is Influenced by the Autoinducers 21-CSP and AI-2

Quorum‐quenching enzymes: Promising bioresources and their opportunities and challenges as alternative bacteriostatic agents in food industry

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