Planar Multielectrode Array Coupled Complementary Metal Oxide Semiconductor Image Sensor for<i>In vitro</i>Electrophysiology

Nakajima, Arata; Noda, Toshihiko; Sasagawa, Kiyotaka; Tokuda, Takashi; Ishikawa, Yasuyuki; Shiosaka, Sadao; Ohta, Jun

doi:10.7567/jjap.50.04dl04

Cited by 2 publications

(1 citation statement)

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“…A CMOS image sensor with an on-chip electrode array was designed as the base chip of the proposed optoelectronic neural interface device. As reported in our previous works 13) 14) , this CMOS image sensor is capable of imaging the brain structure and activities in on-chip configurations. For this work, the functionality of the sensor can be used to monitor the placement of observation target and operation of the LEDs for light stimulation.…”

Section: Design Of Cmos Sensor Chipmentioning

confidence: 62%

[Paper] A CMOS Optoelectronic Neural Interface Device Based on an Image Sensor with On-chip Light Stimulation and Extracellular Neural Signal Recording for Optogenetics

Sawadsaringkarn

Miyatani

Noda

et al. 2013

MTA

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184Multifunctional devices have also be proposed to perform optical stimulation and electric neural measurement simultaneously. Optrode is a group of devices consisting of light-guide structure and electrode for electric measurement 7)~9) . In most cases, one or several light-guides are implemented onto an electrode array. Light is deliverd to the optorode using optical fibers. The optical fiber and wire harness prevent to use the optorodes in freely moving situations. A device with capabilities of local light stimulation and electric neural measurement with fexible interconnection is required for freely-moving situations. In this work, we propose a CMOS-based optoelectronic device which is capable of not only stimulating the neural system with integrated micro light source array, Abstract A CMOS-based optoelectronic device is proposed for on-chip neural stimulation and observation with optogenetic methodology. The device is capable of local light delivery for stimulation and electrical neural signal recording. The device consists of an array of InGaN light emitting diodes (LEDs) and Au stacked bump electrodes integrated on a CMOS image sensor. Capabilities of on-chip light stimulation and signal recordingwere quantitatively characterized. We have also confirmed that neuron-like cells can be cultured on the surface of the device.

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Section: Design Of Cmos Sensor Chipmentioning

confidence: 62%