Placental transfer of intravenous fluoride in the pregnant ewe

Maduska, Albert L.; Ahokas, Robert A.; Anderson, Garland D.; Lipshitz, Jeffrey; Morrison, John C.

doi:10.1016/0002-9378(80)90570-0

Cited by 14 publications

(8 citation statements)

References 10 publications

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“…This is consistent with our previous findings, but the difference is greater than that reported by other investigators for humans (Shen and Taves, 1974) and for sheep (Maduska et al, 1980). The disagreement may be related to species differences, or to differences in analytical methods.…”

Section: Discussionsupporting

confidence: 92%

Effect of an Acute Maternal Fluoride Dose on Fetal Plasma Fluoride Levels and Enamel Fluoride Uptake in Guinea Pigs

et al. 1989

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We conducted this study to measure maternal plasma, fetal plasma, and fetal enamel fluoride concentrations for four hours following an oral F dose to near-term pregnant guinea pigs. We placed female guinea pigs on de-ionized (Group I) or 3-ppm-F (Group II) drinking water prior to breeding and during gestation. On the 57th day of gestation, we administered a maternal dose of NaF solution (0.6 mg F/kg) by stomach tube. We collected samples of maternal plasma, fetal plasma, and fetal enamel at baseline, at 15 and 30 min, and at one, two, and four h after administration of the dose. We assayed samples for F using a modification of the micro-diffusion and ion-specific electrode method. Group I mean baseline F values were: maternal plasma, 0.016; fetal plasma, 0.002; and fetal enamel, 7.0 ppm. Group II mean values were: 0.055, 0.004, and 19.0 ppm. After the maternal fluoride dose, the mean maternal plasma [F] rose sharply for 30 to 60 min and declined to about 50% of peak values by four h. Fetal plasma [F] changed less in absolute values, but similarly to maternal changes relative to baseline. Fetal enamel mean [F] rose more in Group II than in Group I. Baseline F status had an important effect on F uptake in fetal enamel following an acute maternal fluoride dose.

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Section: Discussionsupporting

confidence: 92%

Effect of an Acute Maternal Fluoride Dose on Fetal Plasma Fluoride Levels and Enamel Fluoride Uptake in Guinea Pigs

et al. 1989

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“…It is clear that fluoride passes the placenta and is taken up in the fetal tissues in rats (Buttner and Muhler, 1958;Cohen et al, 1959;Ericsson and Ullberg, 1958;Evans and Phillips, 1939;Katz and Stookey, 1973;Lehman and Muhler, 1954;Maplesden et al, 1960;Murray, 1936;Osborne, 1961;Reid and Cheng, 1927;Roholm, 1937;Truhaut, 1948); guinea pigs (Hudson et al, 1967); mice (Appelgren et al, 1961;Ericsson and Hammarstrom, 1964;Ericsson and Ullberg, 1958); dogs (Knouft et al, 1936); cattle (Bell et al, 1961;Suttie et al, 1957); sheep (Bawden et al, 1964(Bawden et al, , 1965Maduska et al, 1980); rabbits (Ericsson and Malmnas, 1962;Maplesden et al, *n=4 for all three groups. tn = 12 for the 0 ppm group; n =9 for the remaining two groups.…”

Section: Discussionmentioning

confidence: 95%

“…Apparently, the reports by Shen and Taves (1974) and by Maduska et al (1980) are the only studies of maternal and fetal plasma [F] using the currently accepted analytical methods. The former study measured cord blood rather than arterial blood from the fetus proper, but reports useful plasma [F] levels and is of value.…”

Section: Discussionmentioning

confidence: 99%

Prenatal Fluoride Exposure: Measurement of Plasma Levels and Enamel Uptake in the Guinea Pig

Parker

Bawden

1986

J Dent Res

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This study measured the effects of variations in the maternal fluoride intake on changes in maternal plasma, fetal plasma, and fetal enamel fluoride levels of near-term guinea pig pups. Pregnant sows were divided randomly into one of three groups whose drinking water was either de-ionized or contained 5 ppm or 20 ppm fluoride supplied ad libitum. At approximately 55 days' gestation, maternal and fetal plasma and fetal enamel samples were collected and assayed for fluoride. Results showed an increase in mean fluoride concentration for maternal plasma from the de-ionized to the 20-ppm group. Mean fetal plasma fluoride concentrations were lower at baseline and increased much less than did maternal plasma levels. Mean fetal enamel concentrations increased in a fashion similar to that of the maternal plasma levels and exhibited significant differences among all groups.

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“…Thus, the transport of metal ions across the blood-brain barrier (BBB) is the key step in regulating the biometal levels in CNS. Fluoride can penetrate through the placental sac, passes through the milk, and gets accumulated in certain organs of the fetus or pups [20,21]. A series of active or receptormediated transport systems inherent to the BBB vasculature fails to control the entry of fluoride into the brain.…”

Section: Discussionmentioning

confidence: 99%

Effect of Maternal Exposure of Fluoride on Biometals and Oxidative Stress Parameters in Developing CNS of Rat

Narayanaswamy

Piler

2009

Biol Trace Elem Res

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Excessive intake of essential elements agitates elemental homeostasis resulting in their heterogeneous distribution. Distraction of these elements in central nervous system (CNS) have been demonstrated in many neurological disorders, which are vital in generating free radicals, causing oxidative stress, and contributing to neuronal maladies. The developing CNS is highly vulnerable to environmental agents, including fluoride. Fluorosis is one such disorder ensued from excessive consumption of fluoride containing water and/or foods that poses a greater threat to the life. Present study offers perturbations caused by fluoride toxicity on the level of biometal and antioxidant homeostasis and their interactions. Pregnant Wistar rats were exposed to 100- and 200-ppm fluoride (F(-)) in drinking water and controls with tap water. The pups born to them were used for the study. On 21st postnatal day, the concentration of fluoride, biometals, and oxidative stress markers were determined in discrete regions of CNS. The levels of fluoride, copper, and iron increased whereas manganese and zinc were decreased considerably. Among antioxidant enzymes, catalase, superoxide dismutase, and glutathione peroxidase were decreased and lipid peroxidation was increased with regional alterations. The correlation coefficient values among oxidative stress markers and biometals were either positive or negative and showed less significance during correlation. The results confirm that the fluoride provoked oxidative stress and biometal deformations are synergistic that successively governs the neuronal damage and developing CNS no longer prevents exacerbations of fluoride.

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Placental transfer of intravenous fluoride in the pregnant ewe

Cited by 14 publications

References 10 publications

Effect of an Acute Maternal Fluoride Dose on Fetal Plasma Fluoride Levels and Enamel Fluoride Uptake in Guinea Pigs

Effect of an Acute Maternal Fluoride Dose on Fetal Plasma Fluoride Levels and Enamel Fluoride Uptake in Guinea Pigs

Prenatal Fluoride Exposure: Measurement of Plasma Levels and Enamel Uptake in the Guinea Pig

Effect of Maternal Exposure of Fluoride on Biometals and Oxidative Stress Parameters in Developing CNS of Rat

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