Placental oxidative stress and maternal endothelial function in pregnant women with normotensive fetal growth restriction

Yoshida, A.; Watanabe, Kazushi; Iwasaki, Ai; Kimura, Chiharu; Matsushita, Hiroshi; Wakatsuki, Akihiko

doi:10.1080/14767058.2017.1306510

Cited by 17 publications

(7 citation statements)

References 25 publications

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“…Studies have traditionally attempted to determine whether the mechanism of endothelial dysfunction and hypoxia resulting from PE is similar to that in normotensive patients with FGR. A recent study analyzed the relationship between endothelial function and oxidative stress in normotensive women with FGR, compared to those with PE and normal pregnancies, by measuring concentrations of oxygen free radicals (d-ROMs), PlGF, sFlt-1 and placental oxidative damage [ 104 ]. Once the placenta becomes hypoxic, the production of free radicals and hypoxia-inducible factor-1α (HIF-1α) takes place in placenta decidua [ 105 , 106 ].…”

Section: Discussionmentioning

confidence: 99%

“…sFlt-1 serves as a receptor for VEGF and PlGF. However, once sFlt-1 is present in excess, VEGF and PlGF production by placenta is suppressed, resulting in maternal endothelial dysfunction [ 104 ]. Although the maternal serum concentration of sFlt-1 was increased, while that of PlGF was decreased in patients with early- or late-onset PE, levels of those factors in patients with normotensive FGR remained comparable to those with normal pregnancies.…”

Section: Discussionmentioning

confidence: 99%

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Endothelial Dysfunction in Pregnancy Complications

et al. 2021

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The endothelium, which constitutes the inner layer of blood vessels and lymphatic structures, plays an important role in various physiological functions. Alterations in structure, integrity and function of the endothelial layer during pregnancy have been associated with numerous gestational complications, including clinically significant disorders, such as preeclampsia, fetal growth restriction, and diabetes. While numerous experimental studies have focused on establishing the role of endothelial dysfunction in pathophysiology of these gestational complications, their mechanisms remain unknown. Numerous biomarkers of endothelial dysfunction have been proposed, together with the mechanisms by which they relate to individual gestational complications. However, more studies are required to determine clinically relevant markers specific to a gestational complication of interest, as currently most of them present a significant overlap. Although the independent diagnostic value of such markers remains to be insufficient for implementation in standard clinical practice at the moment, inclusion of certain markers in predictive multifactorial models can improve their prognostic value. The future of the research in this field lies in the fine tuning of the clinical markers to be used, as well as identifying possible therapeutic techniques to prevent or reverse endothelial damage.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Endothelial Dysfunction in Pregnancy Complications

et al. 2021

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“…OS, which is an imbalance between pro-oxidants and antioxidants, has been reported among pregnant women who develop PE with increased levels of 8-epi-PGF2α (a marker of endogenous lipid peroxidation) and 8-OHdG (a marker of oxidative DNA damage) and a correspondingly reduced total antioxidant capacity (TAC) compared to normotensive pregnant women. 11 Aside from the involvement of OS in the pathophysiology of PE, OS plays a central role in placental angiogenesis and vasculogenesis. 9, 10 Also, complete placental angiogenesis and vasculogenesis are key to maternal well-being and growth of the foetus.…”

Section: Main Outcome Measuresmentioning

confidence: 99%

Novel prognostic Potential of Early Second Trimester and Mid-pregnancy 8-hydroxy-2-deoxyguanosine/Placental growth factor ratio for preeclampsia: A Longitudinal Nested-Case Control Study

Anto

Coall

Wiafe

et al. 2022

Preprint

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Objective The study used both subjective, Suboptimal Health Status (SHS) concept along with objective, biomarkers of oxidative stress (OS): 8-OHdG, 8-epi-PGF2α and total antioxidant capacity (TAC); and angiogenic growth mediators (AGMs): VEGF-A, sFlt-1, PlGF and soluble endoglin (sEng) for predicting early-onset (EO) and late-onset (LO) preeclampsia (PE) Design A hospital-based longitudinal nested case-control study Setting Obstetrics and Gynaecology Department at Komfo Anokye Teaching Hospital, Ghana Population/Sample Singleton normotensive pregnancies (NTN-P) at baseline W1 (10-20th week gestation) (n= 593) of which 498 (197 developed PE) completed the study. Methods: The overall health status of the NTN-P participants was assessed at W1 and categorised as SHS and optimal health status (OHS) using a validated SHS questionnaire-25. Participants were followed at W2 (21-31st week, mid-pregnancy) and 32-42nd week. Samples were collected and analysed for biomarkers of OS and AGMs at the three-time points. Main Outcome Measures Receiver operative characteristics curve analysis was performed for the single and combined W1 and W2 biomarkers of OS and AGMs for predicting PE and its subtypes (EO-PE and LO-PE) Results Compared to single biomarkers of OS and AGMs, their combined ratios particularly, the W2 8-OHdG/PIGF ratio was a potent biomarker for PE [AUC=0.93]. Additionally, 8-OHdG/PIGF ratio best identified SHS-pregnant women who later developed EO-PE [AUC=0.97] and LO-PE [AUC=0.93]. Moreover, 8-OHdG/PIGF ratio best identified OHS-pregnant women who later developed EO-PE [AUC=0.94] and LO-PE (AUC=0.94). Conclusion Combination of biomarkers of OS and AGMs, particularly, mid-pregnancy 8-OHdG/PlGF ratio is a potent biomarker for PE and its subtypes.

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“…This will have an impact on maternal and infant morbidity and mortality worldwide (2) The placenta is believed to play a central role in every mediator of hypertension (6). The placenta also plays a role in the development of hypertension in which there is disruption of the placenta, poor invasion, and abnormal angiogenesis which are the main pathological manifestations (7). These events are the result of oxidative stress found in hypertensive placentas (8).…”

Section: Introductionmentioning

confidence: 99%

Giving green grass jelly for mda (malondialdehyde) level in pregnant women with hypertension

Rochkmana

Suwondo²,

Sulistyani³

2022

JNKI

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Background: Hypertension is a disease that often occurs during pregnancy. Many factors influence the occurrence of hypertension, one of which is oxidative stress. Oxidative stress has an important role in the pathogenesis of hypertension in pregnancy and may be a pathway that can lead to tissue damage. Oxidative stress can stimulate the release of cytokines, antiangiogenic, microparticles and other important molecules in hypertension. Oxidative stress is caused by an imbalance of prooxidants and antioxidants. So we need antioxidants that can suppress oxidative stress in pregnant women with hypertension. Green grass jelly contains alkaloids and flavonoids. Where flavonoids can act as antioxidants and anti-inflammatory. Flavonoids can reduce arterial stiffness making Reactive Oxygen Species (ROS) decrease so that fat peroxide decreases and is followed by decreased oxidative stress, then endothelial function will increase and vasodilation occurs. Malondialdehyde (MDA) is an aldehyde marker compound that is important to see lipid peroxidation and oxidative damage caused by Reactive Oxygen Species (ROS).Objectives: To prove that giving green grass jelly has an effect on reducing oxidative stress in pregnant women.Methods: This study used a quasy experiment with a pretest and posttest control design. A sample of 30 was divided into 2 groups. The group with green grass jelly intervention was 15 people who were given green grass jelly as much as 150 grams per day for 14 days. The second group as many as 15 people as the control group.Results: The green grass jelly intervention group had a significant difference with p-value <0.05. For malondialdehyde results in the control group there was no change in p-value > 0.05. The mean decrease in malondialdehyde levels in the control group was 0.0560 nmol/ml while the average decrease in malondialdehyde in the intervention group was 1.3133 nmol/ml.Conclusions: Green grass jelly is effective and significant for reducing malondialdehyde levels in pregnant women with mild hypertension.

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Placental oxidative stress and maternal endothelial function in pregnant women with normotensive fetal growth restriction

Abstract: Our findings demonstrate that, despite the presence of placental oxidative DNA damage as observed in PE patients, pregnant women with normotensive FGR show no increase in the concentrations of sFlt-1 and d-ROMs, or a decrease in FMD.

Cited by 17 publications

References 25 publications

Endothelial Dysfunction in Pregnancy Complications

Endothelial Dysfunction in Pregnancy Complications

Novel prognostic Potential of Early Second Trimester and Mid-pregnancy 8-hydroxy-2-deoxyguanosine/Placental growth factor ratio for preeclampsia: A Longitudinal Nested-Case Control Study

Giving green grass jelly for mda (malondialdehyde) level in pregnant women with hypertension

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