Pituitary Tumor Radiosurgery

Trifiletti, Daniel M.; Dutta, Sunil W.; Lee, Cheng‐Chia; Sheehan, Jason P.

doi:10.1159/000493059

Cited by 9 publications

(4 citation statements)

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“…However, until now, there remain no complete and universal diagnostic criteria, so the treatment methods are inconsistent. At present, the mainstays include surgical resection and radiation therapy [11]. However, it is difficult to completely remove with surgery alone due to the property of invasive growth of tumors, and the conjunction treatment plan of surgery-assisted radiation therapy and drug therapy has always been the mainstay.…”

Section: Discussionmentioning

confidence: 99%

A Retrospective Trail Investigating Temozolomide Neoadjuvant Chemotherapy Combined with Radiotherapy in Low-Grade Pituitary Tumors

Cui

Shen

Xiaohong

et al. 2022

Journal of Oncology

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Objective. To study and analyze the clinical application of temozolomide (TMZ) combined with radiotherapy in the treatment of low-grade pituitary tumors. Methods. A retrospective trail was conducted among 67 patients with low-grade pituitary tumors who were treated in our hospital from March 2018 to June 2020. According to different treatment methods, they were assigned into a combined group (37 cases, temozolomide capsules and radiotherapy) and a control group (30 cases, radiotherapy). The changes of serum prolactin (PRL), insulin-like growth factor-1 (IGF-1), GH levels, thyroid-stimulating hormone (TSH), serum free thyroxine (FT4), and adrenocorticotropic hormone (ACTH) were compared. Results. The chi-square test reports a significantly higher total effective rate in the combined group vs. control group (91.89% vs. 70.00%). Significant reductions in serum levels of PRL, IGF-1, and GH were observed in both groups after treatment, whereas the combined group treated with radiotherapy and TMZ resulted in significantly lower levels compared with the control group ( p < 0.05 ). After treatment, TSH decreased, and FT4 and ACTH increased in both groups, and the treatment with radiotherapy and TMZ in the combined group led to a significantly greater amplitude of variation ( p < 0.05 ). Conclusion. The combination of temozolomide and radiotherapy might be a promising technique for the treatment of pituitary tumors, thereby meriting promotion.

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Section: Discussionmentioning

confidence: 99%

A Retrospective Trail Investigating Temozolomide Neoadjuvant Chemotherapy Combined with Radiotherapy in Low-Grade Pituitary Tumors

Cui

Shen

Xiaohong

et al. 2022

Journal of Oncology

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“…The goal of radiosurgery, including all radiosurgery techniques, is to deliver a high dose of radiation to the tumor while minimizing the dose to adjacent critical structures such as the optic structures, hypothalamus, medial temporal lobe, and brainstem. Gamma Knife is a well-validated and modern radiosurgery platform that allows for precise management of pituitary tumors (Trifiletti et al, 2019).…”

Section: Treatmentmentioning

confidence: 99%

“…Pharmacological interventions, such as dopamine agonists for prolactinomas, and surgical approaches, notably the transsphenoidal method, take center stage. Advances like endoscopic surgeries and radiotherapeutic techniques, including Gamma Knife radiosurgery, highlight the ongoing evolution in managing pituitary disorders (Trifiletti et al, 2019). In essence, this literature review is crafted with the intent to synthesize multifaceted aspects of pituitary gland functioning and pathology.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Pituitary Gland Pathology, Anatomy, and Treatment Modalities: A Literature Review

Aqila Yahya,

Novida,

Wahyuhadi

et al. 2023

IJRP

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This comprehensive literature review explores pituitary gland pathology, encompassing anatomy, physiology, and contemporary treatments. It starts by dissecting the gland's anatomy, emphasizing its role as a hormone regulator. The subdivisions, anterior (adenohipofisis) and posterior (neurohipofisis), are examined, detailing nerve fibers and neurotransmitters. Histologically, the anterior pituitary (adenohipofisis) is analyzed, highlighting cell types and their hormone secretions. The posterior pituitary (neurohipofisis) development from the hypothalamus and its hormones, like antidiuretic hormone (ADH) and oxytocin, are explored. Physiologically, the review underscores the regulated hormone secretion influenced by stimuli and feedback. Negative regulation in hormones like thyroid hormones and growth hormone is explored, elucidating hypothalamus-anterior pituitary interplay. The review transitions to pituitary pathologies, focusing on tumors. It classifies, epidemiologizes, and clinically presents pituitary tumors, emphasizing molecular complexities and genetic aspects of tumorigenesis. Closing with treatment modalities, it covers pharmacology, transsphenoidal and transcranial surgeries, and radiotherapies (fractioned stereotactic radiotherapy and Gamma Knife). Synthesizing anatomical, physiological, and clinical insights, this review offers a concise yet comprehensive understanding of pituitary gland pathology and contemporary treatments.

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“…Pituitary tumor represents a common intracranial pathology and pituitary neuroendocrine tumor (PitNET) is the most common type of pituitary tumor, in which usually hormones are abnormally secreted and systematic upwards compression of optic structures occurs, resulting in a wide variety of clinical sequelae ( 1 , 2 ). Transsphenoidal surgery (TSS), known for its simplicity and minimal invasiveness, is widely embraced as the primary treatment for most PitNET cases, with both the endoscope and microscope yielding satisfactory clinical outcomes ( 3 , 4 ).…”

Section: Introductionmentioning

confidence: 99%

Neuronavigation-assisted pituitary neuroendocrine tumor resection: a systematic review and meta-analysis

Huang,

Qin,

et al. 2024

Quant Imaging Med Surg

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Background The advancement of pituitary surgery has rendered it a secure and efficient treatment method; nevertheless, the potential for incomplete tumor removal and cerebrospinal fluid (CSF) leak remains. Neuronavigation-assisted pituitary neuroendocrine tumor (PitNET) resections have been driving a rising number of attentions in recent years. However, there is currently a lack of comprehensive quantitative evaluation of the effectiveness of neuronavigation-assisted pituitary tumor resection. We aimed to assess the curative effects and complications with or without the use of an image-based neuronavigation in PitNET resection. Methods A systematic review and meta-analysis was performed by searching PubMed, EMBASE, Cochrane Library, Web of Science, and Scopus from inception until May 1, 2024 in English to identify any studies reporting gross total resection (GTR) or postoperative complications in patients who underwent neuronavigation-assisted PitNET resection, excluding conference abstracts and studies with fewer than five subjects. We also searched the reference lists of previous systematic reviews and other relevant publications in databases. We reviewed and analyzed the studies that investigated the operative effects and complications of neuronavigation in PitNET resection. Study quality was assessed by the Newcastle-Ottawa scale, and publication bias was evaluated by funnel plot. Review manager 5.3 was employed for meta-analysis. The results were expressed as odds ratio (OR) with 95% confidence interval (CI) of image-assisted techniques for the incidence of GTR and complications. Results A total of 42 publications that fulfilled the established searching criteria were obtained from the above-mentioned databases, all of which with the Newcastle-Ottawa Scale scores ≥ six ★. Among the included publications, 37 studies indicated that the OR of image-based neuronavigation was 2.29 (95% CI: 2.02–2.60, P<0.00001, I 2 =24%) for GTR. The other five studies compared the neuronavigation group (experimental group) and non-neuronavigation group (control group), exhibiting high heterogeneity (I 2 =91%). After sensitivity analysis, the results showed that the rate of the CSF leak of the neuronavigation group was slightly lower than that of the non-neuronavigation group (OR: 0.84, 95% CI: 0.73–0.97, P=0.01, I 2 =43%). Conclusions According to the existing data, neuronavigation-assisted PitNET resection can increase the rates of GTR and reduce the incidence of postoperative complications. Our results provide a reference for the selection of surgical methods for PitNET resection in future clinical practice.

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Pituitary Tumor Radiosurgery

Cited by 9 publications

References 0 publications

A Retrospective Trail Investigating Temozolomide Neoadjuvant Chemotherapy Combined with Radiotherapy in Low-Grade Pituitary Tumors

A Retrospective Trail Investigating Temozolomide Neoadjuvant Chemotherapy Combined with Radiotherapy in Low-Grade Pituitary Tumors

Exploring the Pituitary Gland Pathology, Anatomy, and Treatment Modalities: A Literature Review

Neuronavigation-assisted pituitary neuroendocrine tumor resection: a systematic review and meta-analysis

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