Pituitary responses to thyrotropin releasing hormone stimulation in depressed women with thyroid gland disorders

Bunevičius, Robertas; Lašas, Liudvikas; Kazanavičius, Gintautas; Prange, Arthur J.

doi:10.1016/s0306-4530(96)00022-4

Cited by 9 publications

(4 citation statements)

References 37 publications

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“…The pattern of increase in FT 4 concentrations with normal TSH concentrations corresponds to the description of euthyroid hyperthyroxinemia that has been reported in acute psychotic patients and patients with mood disorders (5,6,(18)(19)(20)(21). We have demonstrated earlier in patients with major depression that concomitant autoimmune thyroiditis (22) or goiter (23) in psychiatric patients with normal TSH concentrations had significant effects on thyroid function assessed by the most sensitive method, the TRH test. Therefore, in the present study, the exclusion of patients and controls with autoimmune thyroid disease, as well as subjects with primary thyroid dysfunction, allowed us to evaluate thyroid axis hormone concentrations in association with psychoses without endocrine bias.…”

Section: Discussionsupporting

confidence: 79%

Concentrations of Thyroid Axis Hormones in Psychotic Patients on Hospital Admission: the Effects of Prior Drug Use

et al. 2012

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The aim of this study was to determine the concentrations of thyroid axis hormones in psychotic patients on hospital admission and to search for the associations between the concentrations of these hormones and prior drug use as well as mental symptoms. Material and Methods. Psychiatric diagnoses, psychotropic drug use, and the severity of psychoses were evaluated using the standard methods on admission. Venous blood from patients and healthy controls was drawn for the analysis of free thyroxin (FT4), free triiodothyronine (FT3), thyroid-stimulating hormone (TSH), and sex hormone-binding globulin (SHBG) concentrations. Results. Eighty-one psychotic patients, free of a thyroid disorder, were enrolled into the study. Compared with the controls, they displayed the higher FT4 concentrations in the general group (P=0.003) and the higher SHBG concentrations only in men (P=0.013). The FT4 concentration was higher in the patients who were not taking an antipsychotic drug on admission (P=0.039). No significant correlation was found between the severity of psychosis and concentrations of thyroid axis hormones. However, the FT3 concentration in the general group and TSH concentration in women correlated with the factor of the Brief Psychiatric Rating Scale expressing elevated mood. Conclusions. Our study confirms the higher FT4 concentrations in a significant proportion of acute psychotic patients. The concentrations of thyroid axis hormones were found to be associated with prior antipsychotic treatment on hospital admission.

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Section: Discussionsupporting

confidence: 79%

Concentrations of Thyroid Axis Hormones in Psychotic Patients on Hospital Admission: the Effects of Prior Drug Use

et al. 2012

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“…Furthermore, anemia is frequently diagnosed in hypothyroid patients as a result of iron deficiency or depressed erythrocyte production by bone marrow affecting the erythrocyte life span. Despite a recent paper concluding that the relationship between thyroid function and depression remains poorly defined [60], it has been observed that in subjects with major depression, a blunted TSH response to TRH stimulation associated with increased concentration of reverse T3 and decreased concentration of T3 can induce low T3 syndrome [61,62]. Interestingly, Bunevicius et al showed that patients with coronary artery disease and depressive symptoms had a higher prevalence of HF, higher NT-pro BNP concentrations and lower T3 than patients with coronary artery disease without depressive symptoms.…”

Section: Hf: a Paradigm Model Of Systemic Disease With Thyroid Systemmentioning

confidence: 99%

Thyroid hormone and heart failure: from myocardial protection to systemic regulation

Sabatino¹,

Iervasi²,

Pingitore³

2014

Expert Review of Cardiovascular Therapy

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Heart failure (HF) is an intriguing model of chronic disease. It starts as an organ disorder developing, in its progression, into a systemic disease in which the dysfunction of other organs plays a relevant clinical and prognostic impact. Furthermore, continuous activation of systemic pathways plays a role in disease progression, switching their effect from protective to harmful. In this combination of organ dysfunction and systemic derangement, thyroid hormone (TH) have an important regulative impact from cardiovascular to systemic level and from molecular/cellular processes to clinical setting. Whether it is accepted to include TH and thyroid stimulating hormone assessment in the clinical HF course, the next challenge will be to ascertain the benefit of TH replacement therapy in HF patients, taking into consideration the type of hormone to administer, dosage and treatment schedule.

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“…A recent study of Grabe et al (2005) found that a general population of women with AITD, diagnosed by hypoechoic thyroid pattern and by the presence of thyroid antibodies in serum, showed higher scores of anxiety independently from their thyroid function. It may be that it is not marginal thyroid dysfunction, but rather thyroid autoimmune processes, frequently responsible for this dysfunction (Bunevicius et al, 1994(Bunevicius et al, , 1996, that are responsible for co-morbidity with mood disorders. In our study we did not assess thyroid axis hormone concentrations and did not address this important question directly.…”

Section: Discussionmentioning

confidence: 99%

Mood and thyroid immunity assessed by ultrasonographic imaging in a primary health care

Bunevičius

Pečeliūnienė

Mickuvienė³

et al. 2007

Journal of Affective Disorders

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Pituitary responses to thyrotropin releasing hormone stimulation in depressed women with thyroid gland disorders

Cited by 9 publications

References 37 publications

Concentrations of Thyroid Axis Hormones in Psychotic Patients on Hospital Admission: the Effects of Prior Drug Use

Concentrations of Thyroid Axis Hormones in Psychotic Patients on Hospital Admission: the Effects of Prior Drug Use

Thyroid hormone and heart failure: from myocardial protection to systemic regulation

Mood and thyroid immunity assessed by ultrasonographic imaging in a primary health care

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