Pinocembrin prevents glutamate-induced apoptosis in SH-SY5Y neuronal cells via decrease of bax/bcl-2 ratio

Chemical Analysis and Antimicrobial Effect of Propolis from Hakkari Province of Turkey against Some Pathogenic Microorganisms

“…Our results are in agreement with the findings of Stepanovic et al (27). Many studies have shown that gram positive bacteria are more susceptible to the antimicrobial effect of propolis than gram negative bacteria (28,29 (32) reported that the pinocembrin (5,7-dihidroksiflavanon) is a compound that can be found in very high concentrations in propolis and, is responsible for antimicrobial activity of propolis. Accordingly, antimicrobial activity of the propolis sample we investigated can be related to the rate of this compound.…”

Pinocembrin, a major flavonoid in propolis, improves the biological functions of EPCs derived from rat bone marrow through the PI3K-eNOS-NO signaling pathway

“…Pinocembrin (PIN, 5,7-dihydroxyflavanone), one of the major flavonoids in propolis, exhibits many pharmacological activities, including anti-inflammatory, antioxidant, anti-thrombotic, antimicrobial, anti-allergic, hepatoprotective, anti-viral, cancer chemopreventive, anti-asthmatic and endothelium-relaxation effects (Sala et al 2003;Santos et al 1998;Hwang et al 2003;Pepeljnjak et al 1985). A recent study found that low-doses of PIN provide acute neurovascular protection in a glutamate injury model partly through the inhibition of p53 expression and cytochrome c release and by changing the Bax/Bcl2 ratio (Gao et al 2008). High doses of PIN induce mitochondrial apoptosis in a variety of cancer cells but are nontoxic to human umbilical cord endothelial cells (Kumar et al 2007).…”

Protection of mice against lipopolysaccharide-induced endotoxic shock by pinocembrin is correlated with regulation of cytokine secretion

“…Pinocembrin inhibited the up-regulation of the receptor for advanced glycation end product (RAGE) transcripts and protein expression both in vivo and in vitro, and regulated mitochondrionmediated apoptosis by restoration of B-cell lymphoma 2 and cytochrome c and inactivation of caspase 3 and caspase 9 (Liu et al, 2012). Other studies showed that pinocembrin reduced glutamate-induced SH-SY5Y cell injury and (primary) cultured cortical neuron damage in oxygen-glucose deprivation/re-oxygenation (OGD/R) scenarios (Gao et al, 2008a), alleviated cerebral ischemic injury in middle cerebral artery occlusion in rats (Gao et al, 2008b), and improved cognition by protecting cerebral mitochondria structure and function against chronic cerebral hypoperfusion in rats (Guang & Du, 2006). Although those previous studies have clearly shown the beneficial effects of pinocembrin in animals, little is known about its anti-inflammatory effects in general.…”