Pinin acts as a poor prognostic indicator for renal cell carcinoma by reducing apoptosis and promoting cell migration and invasion

Jin, Ming; Li, Dan; Liu, Weihong; Wang, Ping; Xiang, Zhenfei; Liu, Kaitai

doi:10.1111/jcmm.16495

Cited by 12 publications

(16 citation statements)

References 25 publications

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“…A study reported that PNN was markedly related to T cell receptor signaling pathway in renal cell carcinoma, and has a positive correlation with TIICs (24). At present study, we found that overexpressed PNN was signi cantly associated with resting NK cells and naive CD4 + T cells in COAD, conversely, PNN low expression were more enriched with CD8 + T cells, regulatory T cells (Tregs) and resting dendritic cells.…”

Section: Discussionsupporting

confidence: 47%

Integrative Analysis of Pinin as A Prognostic Factor in Digestive Tract Cancers

Zhang¹,

Jin²,

Ye³

et al. 2021

Preprint

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Background: Pinin (PNN) was originally identified for acting an essential role in epithelial cell-cell adhesion. We aim to illuminate the expression profile, mutation feature, methylation status of PNN and its prognostic value in digestive tract cancers. Methods: Expression and methylation data of PNN, as well as clinical information on esophagus cancer (ESCA), gastric adenocarcinoma (STAD), colon adenocarcinoma (COAD) and rectal adenocarcinoma (READ) were acquired from The Cancer Genome Atlas database. The value of PNN expression, mutation feature and methylation status in prognosis were assessed. GO enrichment and Gene set enrichment analysis were performed to investigate the enriched biological functions and pathways of PNN in COAD. Tumor Immune Estimation Resource and CIBERSORT were applied for evaluating the effects of PNN on tumor immune infiltrating cells. Results: PNN was significantly overexpressed in digestive tract cancers and was remarkably related to tumor stage. Highly expressed of PNN was positively related to poor free survival (PFS) and overall survival (OS) in COAD. Additionally, 10 CpG sites methylation in PNN had significant effects on survival. PNN expression was confirmed as an independent prognostic factor for predicting the OS in COAD. GO and GSEA analyses revealed that PNN participates in multiple biological processes underlying carcinogenicity in COAD. PNN was significantly associated with TIICs. Moreover, a promising prognostic nomogram incorporating the PNN expression and clinicopathological characteristics was established for predicting OS probability in COAD. Conclusions: Our comprehensive bioinformatics study demonstrated that PNN was highly expressed in digestive tract cancers, which could act as an independent prognostic factor for COAD.

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Section: Discussionsupporting

confidence: 47%

Integrative Analysis of Pinin as A Prognostic Factor in Digestive Tract Cancers

Zhang¹,

Jin²,

Ye³

et al. 2021

Preprint

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“…A study reported that PNN was strongly related to the T cell receptor signaling pathway in renal cell carcinoma and had a positive correlation with TIICs. 6 In the present study, we found that Many clinical trials combining blockade of TIM3 with other checkpoint inhibitors, such as PD-1, PD-L1, and LAG3, are ongoing. 55 The TIDE and IPS analyses showed a lower TIDE score and higher IPS in the low expression group, suggesting that low expression of PNN might indicate a better clinical response to ICI treatment.…”

Section: Discussionmentioning

confidence: 70%

The prognostic effect of PNN in digestive tract cancers and its correlation with the tumor immune landscape in colon adenocarcinoma

Zhang

Jin

et al. 2022

Clinical Laboratory Analysis

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Background The present study investigated the expression, mutation, and methylation profile of PNN and its prognostic value in digestive tract cancers. The disparities in signaling pathways and the immune landscape in colon adenocarcinoma (COAD) based on PNN expression were specifically explored. Methods The expression, mutation, methylation levels of PNN, and survival data in esophageal cancer, gastric adenocarcinoma, COAD, and rectal adenocarcinoma were evaluated using several bioinformatic databases. Gene Ontology (GO) enrichment analysis and gene set enrichment analysis (GSEA) were performed to investigate the enriched biological functions and pathways in COAD. Several acknowledged bioinformatic algorithms were employed to assess the correlation between PNN expression and the tumor immune landscape in COAD. Results PNN was upregulated and remarkably related to tumor stage in digestive tract cancers. High expression of PNN was positively associated with poor progression‐free survival and overall survival time, specifically in COAD. PNN expression was identified as an independent prognostic factor in COAD. GO and GSEA analyses revealed that PNN participates in multiple biological processes underlying carcinogenicity in COAD. Further investigation showed that PNN expression was significantly associated with tumor‐infiltrating immune cells, immune cell functions, and several immune checkpoints in COAD. The PNN low expression group had a lower tumor immune dysfunction and exclusion (TIDE) score and a higher immunophenoscore (IPS), indicating a better response to immunotherapy. Conclusion PNN was highly expressed in digestive tract cancers and could act as an independent prognostic factor and a response predictor for immunotherapy in COAD.

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“…Gene set enrichment analysis (high-risk score group vs. low-risk score group) (version 4.1.0; http://software.broadinstitute.org/gsea/index.jsp ) was performed to investigate the potential molecular mechanisms by which the risk score model might act on tumor progression in COAD, as previously described [ 78 , 79 ]. FDR <0.05 was used to identify significantly enriched pathways.…”

Section: Methodsmentioning

confidence: 99%

Establishment of a novel ferroptosis-related lncRNA pair prognostic model in colon adenocarcinoma

Liu

Huang

et al. 2021

Aging

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Long non-coding RNAs (lncRNAs) have been reported to be prognostic factors for cancer. Ferroptosis is an iron-dependent process of programmed cell death. Here, we established a ferroptosis-related lncRNA (frlncRNA) pair signature and revealed its prognostic value in colon adenocarcinoma (COAD) by analyzing the data from The Cancer Genome Atlas (TCGA). FrlncRNAs were identified based on co-expression analysis using the Pearson correlation. Differentially expressed frlncRNAs (DEfrlncRNAs) were recognized and paired, followed by prognostic assessment using univariate Cox regression analysis. The least absolute shrinkage and selection operator (LASSO) penalized Cox analysis was used to determine and construct a risk score prognostic model, by which the receiver operating characteristic (ROC) curves for predicting the overall survival (OS) were conducted. Following the evaluation of whether it was an independent prognostic factor, correlations between the risk score model and clinicopathological characteristics, hypoxia- and immune-related factors, and somatic variants were investigated. In total, 148 DEfrlncRNA pairs were identified, 25 of which were involved in a risk score prognostic signature. The area under ROC curves (AUCs) representing the predictive effect for 1-, 3-, and 5-year survival rates were 0.860, 0.885, and 0.934, respectively. The risk score model was confirmed as an independent prognostic factor and was significantly superior to the clinicopathological characteristics. Correlation analyses showed disparities in clinicopathological characteristics, hypoxia- and immune-related factors, and somatic variants, as well as specific signaling pathways between high- and low-risk groups. The novel risk score prognostic model constructed by pairing DEfrlncRNAs showed promising clinical prediction value in COAD.

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Pinin acts as a poor prognostic indicator for renal cell carcinoma by reducing apoptosis and promoting cell migration and invasion

Cited by 12 publications

References 25 publications

Integrative Analysis of Pinin as A Prognostic Factor in Digestive Tract Cancers

Integrative Analysis of Pinin as A Prognostic Factor in Digestive Tract Cancers

The prognostic effect of PNN in digestive tract cancers and its correlation with the tumor immune landscape in colon adenocarcinoma

Establishment of a novel ferroptosis-related lncRNA pair prognostic model in colon adenocarcinoma

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