Establishment of a novel ferroptosis-related lncRNA pair prognostic model in colon adenocarcinoma

Abstract

Long non-coding RNAs (lncRNAs) have been reported to be prognostic factors for cancer. Ferroptosis is an iron-dependent process of programmed cell death. Here, we established a ferroptosis-related lncRNA (frlncRNA) pair signature and revealed its prognostic value in colon adenocarcinoma (COAD) by analyzing the data from The Cancer Genome Atlas (TCGA). FrlncRNAs were identified based on co-expression analysis using the Pearson correlation. Differentially expressed frlncRNAs (DEfrlncRNAs) were recognized and paired, followed by prognostic assessment using univariate Cox regression analysis. The least absolute shrinkage and selection operator (LASSO) penalized Cox analysis was used to determine and construct a risk score prognostic model, by which the receiver operating characteristic (ROC) curves for predicting the overall survival (OS) were conducted. Following the evaluation of whether it was an independent prognostic factor, correlations between the risk score model and clinicopathological characteristics, hypoxia- and immune-related factors, and somatic variants were investigated. In total, 148 DEfrlncRNA pairs were identified, 25 of which were involved in a risk score prognostic signature. The area under ROC curves (AUCs) representing the predictive effect for 1-, 3-, and 5-year survival rates were 0.860, 0.885, and 0.934, respectively. The risk score model was confirmed as an independent prognostic factor and was significantly superior to the clinicopathological characteristics. Correlation analyses showed disparities in clinicopathological characteristics, hypoxia- and immune-related factors, and somatic variants, as well as specific signaling pathways between high- and low-risk groups. The novel risk score prognostic model constructed by pairing DEfrlncRNAs showed promising clinical prediction value in COAD.

A Novel Ferroptosis-Related LncRNA Pair Prognostic Signature Predicts Immune Landscapes and Treatment Responses for Gastric Cancer Patients

“…Table 1 lists recent works that constructed ferroptosis-related lncRNA risk score models in GC. It is worth noting that some recent studies cyclically singly paired the ferroptosis-related lncRNAs and constructed prognostic risk score models of lncRNA pairs ( Li et al, 2021 ; Tang et al, 2021 ). Compared with the aforementioned risk score model consisting of single lncRNA, these models did not rely on the specific expression of lncRNA and had broader clinical practicability, for it is unnecessary to transform data format when the expression profiles were obtained from different sequencing platforms.…”

Development and Validation of a Ferroptosis-Related lncRNAs Prognosis Model in Oral Squamous Cell Carcinoma

“…Morever, many lncRNAs are involved in the progression of malignant tumors and tumor resistance, and have become new biomarkers and therapeutic targets in cancer diagnosis and treatment (Wang et al, 2019a). The excellent predictive ability of frlncRNAs in cancer has been confirmed in a variety of cancers (Chen et al, 2021b;Lu et al, 2021;Jin et al, 2021;Li et al, 2021). However, the mechanism of frlncRNAs in OSCC is still unclear.…”

Ferroptosis-related long non-coding RNA signature predicts the prognosis of hepatocellular carcinoma

“…Notably, new research shows that several lncRNAs can play an important role in regulating the occurrence and development of diseases through promoting ferroptosis [ 33 – 35 ]. At present, the ferroptosis-associated lncRNA prognostic signature models have been reported in other malignancies [ 36 – 38 ]. However, there was rarely research about the ferroptosis-associated lncRNA prognostic signature model in HCC.…”