Pilosocereus gounellei (Cactaceae) stem extract decreases insulin resistance, inflammation, oxidative stress, and cardio-metabolic risk in diet-induced obese mice

Oliveira, Alisson Macário de; Freitas, Anderson Felipe Soares de; Costa, Milena Damasceno de Souza; Torres, Marília Kalinne da Silva; Castro, Yasmim Alline de Araújo; Almeida, Ana Maria Rampeloti; Paiva, Patrícia Maria Guedes; Carvalho, Bruno; Napoleão, Thiago Henrique

doi:10.1016/j.jep.2020.113327

Cited by 10 publications

(4 citation statements)

References 47 publications

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“…As expected, besides a significant increase of body weight and FM [30], the HFD increased systemic OS, as shown by the quantification of different pro/antioxidant markers in plasma [39][40][41]. Moreover, as previously shown, the HFD modified, but to a lesser extent, the pro/antioxidant status also in liver and adipose tissue [42,43].…”

Section: Discussionsupporting

confidence: 75%

Beneficial Effects of High Intensity Interval Training and/or Linseed Oil Supplementation to Limit Obesity-Induced Oxidative Stress in High Fat Diet-Fed Rats

et al. 2021

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High-intensity interval training (HIIT) and linseed oil (LO) supplementation are effective strategies to reduce obesity-induced oxidative stress. Our aim was to determine whether the HIIT + LO combination prevents obesity-induced oxidative stress in high fat diet (HFD)-fed rats. HFD-fed 8-week-old, male, Wistar rats were subdivided in four groups: HFD, LO (2% of sunflower oil replaced with 2% of LO in the HFD), HIIT (4 days/week for 12 weeks), and HIIT + LO. Wistar rats fed a low-fat diet (LFD) were used as controls. Epididymal and subcutaneous adipose tissue, gastrocnemius muscle, liver, and plasma samples were collected to measure oxidative stress markers (AOPP, oxLDL), antioxidant (SOD, CAT, and GPx activities) and pro-oxidant (NOx and XO) enzyme activities. Compared with the LFD, the HFD altered the pro/antioxidant status in different tissues (increase of AOPP, oxLDL, SOD and catalase activities in plasma, and SOD activity increase in liver and decrease in adipose tissues) but not in gastrocnemius. LO upregulated CAT activity and decreased NOx in liver. HIIT alleviated HFD negative effects in liver by reducing SOD and NOx activities. Moreover, the HIIT + LO combination potentiated SOD activity upregulation in subcutaneous tissue. HIIT and LO supplementation have independent beneficial effects on the pro/antioxidant balance. Their association promotes SOD activity in subcutaneous adipose tissue.

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Section: Discussionsupporting

confidence: 75%

Beneficial Effects of High Intensity Interval Training and/or Linseed Oil Supplementation to Limit Obesity-Induced Oxidative Stress in High Fat Diet-Fed Rats

et al. 2021

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“…LPH-treated mice showed not only lower plasma concentrations of TC, LDL-C, and TG with respect to the untreated control group but also a significant reduction of CRI (I), CRI (II), and AIP. This is of special interest given that these indexes are used as optimal indicators of cardiovascular risk, and are considered more sensitive and specific than individual lipid parameters, both in humans and mice. ,, Interestingly, the effect of LPH on blood lipid lowering was not related to diet intake or BWG that were not altered between groups. Although other authors have described that whole lupin protein exert a lipid-lowering effect in animals and humans, , we are not aware of previous studies demonstrating the wide range of hypolipidemic effects of lupin protein hydrolysates related to atherosclerosis described in the present work.…”

Section: Discussionmentioning

confidence: 99%

Bioactive Peptides from Lupin (Lupinus angustifolius) Prevent the Early Stages of Atherosclerosis in Western Diet-Fed ApoE^–/– Mice

Santos-Sánchez

Cruz‐Chamorro

Álvarez-Ríos

et al. 2022

J. Agric. Food Chem.

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We have previously reported the in vitro hypocholesterolemic, anti-inflammatory, and antioxidant effects of Alcalasegenerated lupin protein hydrolysate (LPH). Given that lipoprotein deposition, oxidative stress, and inflammation are the main components of atherogenesis, we characterized the LPH composition, in silico identified LPH−peptides with activities related to atherosclerosis, and evaluated the in vivo LPH effects on atherosclerosis risk factors in a mouse model of atherosclerosis. After 15 min of Alcalase hydrolysis, peptides smaller than 8 kDa were obtained, and 259 peptides out of 278 peptides found showed biological activities related to atherosclerosis risk factors. Furthermore, LPH administration for 12 weeks reduced the plasma lipids, as well as the cardiovascular and atherogenic risk indexes. LPH also increased the total antioxidant capacity, decreased endothelial permeability, inflammatory response, and atherogenic markers. Therefore, this study describes for the first time that LPH prevents the early stages of atherosclerosis.

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“…These indexes are widely used as predictors of cardiovascular disease risk in humans and mice. 34–36 Likewise, no significant differences were found between both hydrolysates, which supports the generation of the LPH through the economical use of immobilized enzyme.…”

Section: Discussionmentioning

confidence: 60%

Characterisation and beneficial effects of a Lupinus angustifolius protein hydrolysate obtained by immobilisation of the enzyme alcalase®

Santos-Sánchez,

Cruz-Chamorro,

Márquez-López

et al. 2024

Food Funct.

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Pilosocereus gounellei (Cactaceae) stem extract decreases insulin resistance, inflammation, oxidative stress, and cardio-metabolic risk in diet-induced obese mice

Cited by 10 publications

References 47 publications

Beneficial Effects of High Intensity Interval Training and/or Linseed Oil Supplementation to Limit Obesity-Induced Oxidative Stress in High Fat Diet-Fed Rats

Beneficial Effects of High Intensity Interval Training and/or Linseed Oil Supplementation to Limit Obesity-Induced Oxidative Stress in High Fat Diet-Fed Rats

Bioactive Peptides from Lupin (Lupinus angustifolius) Prevent the Early Stages of Atherosclerosis in Western Diet-Fed ApoE^–/– Mice

Characterisation and beneficial effects of a Lupinus angustifolius protein hydrolysate obtained by immobilisation of the enzyme alcalase®

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Pilosocereus gounellei (Cactaceae) stem extract decreases insulin resistance, inflammation, oxidative stress, and cardio-metabolic risk in diet-induced obese mice

Cited by 10 publications

References 47 publications

Beneficial Effects of High Intensity Interval Training and/or Linseed Oil Supplementation to Limit Obesity-Induced Oxidative Stress in High Fat Diet-Fed Rats

Beneficial Effects of High Intensity Interval Training and/or Linseed Oil Supplementation to Limit Obesity-Induced Oxidative Stress in High Fat Diet-Fed Rats

Bioactive Peptides from Lupin (Lupinus angustifolius) Prevent the Early Stages of Atherosclerosis in Western Diet-Fed ApoE–/– Mice

Characterisation and beneficial effects of a Lupinus angustifolius protein hydrolysate obtained by immobilisation of the enzyme alcalase®

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Product

Resources

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Bioactive Peptides from Lupin (Lupinus angustifolius) Prevent the Early Stages of Atherosclerosis in Western Diet-Fed ApoE^–/– Mice