Pilomatrix Carcinoma of the Scalp

Zagarella, Samuel; Kneale, Kenneth; Stern, Harvey

doi:10.1111/j.1440-0960.1992.tb00051.x

Cited by 14 publications

(5 citation statements)

References 11 publications

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“…In the presence of Wnt ligand, b-catenin is not phosphorylated and translocates to the nucleus and acts with the lymphocyte enhancer factor/T-cell factor family of transcription factors to activate transcription of target genes. 3,4,[6][7][8]10,11,13,16,17,21,24,25,27,29 The main differential includes proliferating pilomatrixoma, aggressive pilomatrixoma, and basal cell carcinoma with matrical differentiation (Table 2). 2,4,7,9,10 However, aneuploidy has been observed in few cases of pilomatrix carcinoma and may be of value in discriminating these neoplasms in the future after further detailed analysis.…”

Section: Discussionmentioning

confidence: 99%

“…35 Basal cell carcinoma with matrical differentiation will often display characteristic features such as peripheral palisading, retraction artifact, and a surrounding desmoplastic stroma. 9,24,29 Squamous cell carcinoma may contain cytologic features similar to the basaloid cells of pilomatrix carcinoma but lack ghost cells. 3 In addition, staining with b-catenin will reveal a cytoplasmic or membranous positivity versus both nuclear and cytoplasmic staining with pilomatrix carcinoma.…”

Section: Discussionmentioning

confidence: 99%

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Pilomatrix Carcinoma

Cornejo

Deng

2013

The American Journal of Dermatopathology

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Pilomatrixoma is a common benign neoplasm of children and young adults with a female predilection. In contrast, its malignant counterpart, pilomatrix carcinoma is a rare neoplasm of older adults with a male preponderance. Pilomatrix carcinomas are locally aggressive with a tendency to recur. We report a case of a 44-year-old male who presented with an enlarging soft tissue tumor on the right upper back. Histology revealed an asymmetric, poorly circumscribed, lobulated neoplasm located deeply in the dermis with infiltration into the underlying subcutaneous tissue. The tumor was comprised of basaloid cells containing vesicular nuclei, prominent nucleoli, scant cytoplasm, and brisk mitotic activity. A focus of basaloid cells transitioning to shadow cells with central keratinized material and tumor necrosis was also present. The diagnosis of a pilomatrix carcinoma was rendered. Considering the infiltrative nature of this neoplasm with perineural and intramuscular invasion, the patient underwent 3 surgical excisions before it was completely removed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pilomatrix Carcinoma

Cornejo

Deng

2013

The American Journal of Dermatopathology

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“…In 1993, a series of 20 patients with pilomatrix carcinoma was reported and 23 other patients in the literature were reviewed 4 . There are a further 36 cases in the world literature 5,9–40 . It has been disputed whether these 79 reported cases are all true carcinomas and some may be benign pilomatrixomas with atypical histology or behaviour 6 .…”

Section: Discussionmentioning

confidence: 99%

CASE REPORT Concurrent pilomatrix carcinoma and giant pilomatrixoma

2001

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A 52-year-old man presented with a large, fungating mass on the inner aspect of his left thigh and a smaller hard mass on the inner aspect of his left knee with normal overlying skin. Both lesions had first been noted by the patient 1 year previously and for the first 6 months had a similar appearance until the thigh mass rapidly increased in size and fungated. Pathology of the large thigh lesion showed pilomatrix carcinoma while that of the smaller knee lesion was typical of pilomatrixoma. The pilomatrix carcinoma was widely excised and there has been no evidence of recurrence or metastasis after 3 years. The clinical course of the thigh lesion suggested that pilomatrix carcinoma may arise from a pre-existing pilomatrixoma. On review of the literature, pilomatrix carcinoma of the lower limb may be more likely to metastasize than those on other sites.

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“…Translation of articles in Spanish, French, Italian, German, and Chinese was performed using Google translate (http://translate.google.com) or native speakers of the language. We identified 78 publications worldwide reporting a total of 135 distinct individual cases of pilomatrix carcinoma …”

Section: Literature Reviewmentioning

confidence: 99%