Pilomatrix Carcinoma

Cornejo, Kristine M.; Deng, April

doi:10.1097/dad.0b013e318274b7da

Cited by 33 publications

(53 citation statements)

References 36 publications

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“…The commonest location was the head and neck region (61%) (with the mid face being the most commonly affected area), followed by the trunk (13%), upper extremities (12%), the lower extremities (8%) and genitalia (6%) . Of the 64% of lesions where laterality was reported, pilomatrix carcinoma was found to be more common on the left (67%) . This was consistent throughout the body except for the lower extremity where the lesions were only found on the right.…”

Section: Resultsmentioning

confidence: 91%

“…Preoperatively, all patients underwent clinical examination of their lesions. For the 20 lesions (56%) where the accuracy of clinical examination was reported, none were correctly diagnosed.…”

Section: Resultsmentioning

confidence: 96%

“…Thirty‐six patients underwent excision of a total of 35 solitary pilomatrix carcinomas and one solitary pilomatrical carcinosarcoma . There was a male predominance; 21 male patients (58%) compared to 15 female patients (42%) (male to female ratio of 1.4:1).…”

Section: Resultsmentioning

confidence: 99%

“…Information regarding initial clinical presentation was available for 22 patients . The commonest presentation was of an asymptomatic, firm, mobile nodule . Four patients presented with manifestations of locoregional disease or distant metastases, which included shoulder pain, dysphagia, severe back pain, bleeding and paraplegia .…”

Section: Resultsmentioning

confidence: 99%

“…Information regarding histological features was available for 33 lesions (92%) . All lesions had basaloid cells with atypia and/or raised mitotic index.…”

Section: Resultsmentioning

confidence: 99%

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Pilomatrix carcinoma: 12‐year experience and review of the literature

Jones

Twoon

et al. 2017

J Cutan Pathol

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Pilomatrix carcinoma is a rare, locally aggressive tumor with a tendency to recur. Distant metastases have been reported, with pulmonary lesions being the most frequent manifestation. Similar to pilomatrixoma, pilomatrix carcinoma typically presents as a nontender, firm dermal swelling and is found most commonly in the head and neck region. Although pilomatrixomas and pilomatrix carcinoma are well-recognized lesions, clinically they are frequently misdiagnosed as other skin conditions. By reviewing the literature over the past 10 years, the aims of this review are to analyze the cause, clinical presentation, histopathologic features, management and outcomes of pilomatrix carcinoma amongst children and adults. Pilomatrix carcinoma is a rare, locally aggressive tumor with a tendency to recur. 6-8 Distant metastases have been reported, with pulmonary lesions being the most frequent manifestation. 7-10 Similar to pilomatrixoma, pilomatrix carcinoma typically presents as a nontender, firm dermal swelling [3][4][5][6]8,11 and is found most commonly in the head and neck region. 9,11In contrast to benign pilomatrixomas, which show a bimodal occurrence with a slight female predominance, 2,5 pilomatrix carcinoma commonly occurs in the 5th to the 7th decade with a male to female ratio of 4:1. 9,12Given its rarity, a gold standard treatment regimen has not been established, however, most studies recommend wide local excision with or without adjuvant radiotherapy.

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Section: Resultsmentioning

confidence: 91%

Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Information regarding histological features was available for 33 lesions (92%) . All lesions had basaloid cells with atypia and/or raised mitotic index.…”

Section: Resultsmentioning

confidence: 99%

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Pilomatrix carcinoma: 12‐year experience and review of the literature

Jones

Twoon

et al. 2017

J Cutan Pathol

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Tumours of Skin Appendages

Calonje

2016

Rook's Textbook of Dermatology, Ninth Edition

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This chapter on cutaneous appendageal tumours covers the spectrum of lesions displaying eccrine, apocrine, sebaceous and follicular differentiation. It includes cysts, hamartomas and benign and malignant tumours. Traditionally, appendageal tumours have been classified according to rigid criteria separating lesions with eccrine, apocrine, sebaceous and follicular differentiation. This separation is clearly artificial and it is now acknowledged that lesions regarded as strictly eccrine may well have apocrine differentiation and lesions classified as purely follicular may exhibit apocrine differentiation reflecting the close embryological relationship between the pilosebaceous unit and the apocrine gland.

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