Management of Pilomatrix Carcinoma: A Case Report of Successful Treatment with Mohs Micrographic Surgery and Review of the Literature

Melancon, Jeffrey M.; Tom, Wynnis L.; Lee, Robert A.; Jackson, Michelle; Jiang, Shang I Brian

doi:10.1111/j.1524-4725.2011.02170.x

Cited by 40 publications

(67 citation statements)

References 74 publications

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“…Since PC was initially described by Lopansri and Mihm in 1980, only 136 cases of PC (including 15 cases published in Chinese with English abstracts) have been reported in the English literature worldwide (3)(4)(5). Another 28 such cases have been reported in the Chinese literature.…”

Section: Discussionmentioning

confidence: 99%

“…The transition to squamous cells, clear cells, areas of necrosis and frequent mitoses is associated with metrical cornification in PC (3). Additional characteristics include the appearance of an infiltrative pattern that is asymmetric with frequent invasion of fat and other underlying structures, such as vascular, lymphatic or perineural invasion (3,12). In the present case, sheets and nests of basaloid cells with prominent central necroses and nuclear pleomorphism, typical shadow cells, atypical mitoses and infiltration of the parotid gland and nervi facialis were observed.…”

Section: Discussionmentioning

confidence: 99%

“…The higher radiation doses that are applied with interstitial high dose rate brachytherapy may be of advantage in treating not only recurrent PC, but also residual or newly diagnosed PC (18). Certain authors consider that chemotherapy has not been proven effective (1,3). However, to the best of our knowledge, systemic chemotherapy has been used in 2 cases of metastatic PC, and these cases have exhibited a response (1,19).…”

Section: Discussionmentioning

confidence: 99%

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Pilomatrix carcinoma on the left side of the parotid region: A case report and review of the literature

Liu

Li²,

Fan

et al. 2015

Oncology Letters

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Abstract. Pilomatrix carcinoma (PC) is a rare neoplasm, particularly in the parotid region. Thus, it is easily misdiagnosed and an optimal treatment regimen has not yet been established. The present study reports the case of a 43-year-old female who presented with a PC of the parotid region and reviews the associated published literature. The patient underwent three surgical excisions prior to the tumor being completely removed, and was misdiagnosed four times prior to the correct diagnosis. Once the tumor was completely removed, the patient received radiation therapy (RT). At the 2-year follow-up, the patient remained free of local recurrence and metastasis. To the best of our knowledge, only 3 cases of PC on the parotid region have been reported. Although an optimal treatment regimen has not been established, surgery with wide margins is recommended, with RT and chemotherapy producing mixed results. IntroductionPilomatrix carcinoma (PC) is a rare and malignant adnexal tumor of hair matrix origin (1). The tumor is a dermo-hypodermic in nature, with a low metastatic potential, but a high risk of recurrence following excision. PC is characterized by a locally-aggressive and low-potential malignant lesion, which is likely to be misdiagnosed. However, distant metastasis and mortality have also been reported (2). To highlight a further case of this extremely rare occurrence, the present study reports a case of PC of the parotid region that was misdiagnosed numerous times, and reviews the pertinent literature. Case reportA 43-year-old female first visited the Department of Head and Neck Surgery of Jiangyou City People's Hospital (Jiangyou, Sichuan, China) in 2009 due to a tenacious subcutaneous nodule that was 1.0 cm in diameter on the left side of the parotid region. The small, subcutaneous nodule was asymptomatic, and had been slowly increasing in size for the past 5 years. The nodule was surgically excised under local anesthesia with a false clinical diagnosis of an adenolymphoma of the parotid gland. However, 1 year later, a tenacious mass with an unclear boundary reappeared at the previous site. A secondary excision was performed at the same hospital, and the histological evaluation revealed a squamous epithelial cell mass and cells with hyperchromatic nuclei among fibrous tissue, reactive hyperplasia of the lymph node and partial epithelial proliferation among the tissues. A gray-black nodule with swelling and effusion appeared 3 months later at the site of the primary lesion. The patient was admitted to the same hospital once more. A biopsy of the nodes revealed a well-differentiated squamous cancer. The patient was then transferred to our hospital for further diagnosis and therapy.Upon physical examination, a 2.0x2.0-cm, tender, firm, non-fluctuant, gray-black lesion was noted on the skin surface of the left side of the parotid region (Fig. 1). There was no palpable lymphadenopathy of the left side of the neck. Sensation around the area and salivation were normal. There was no facial nerve dysfunction or dete...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Pilomatrix carcinoma on the left side of the parotid region: A case report and review of the literature

Liu

Li²,

Fan

et al. 2015

Oncology Letters

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“…Surgical management is generally the standard. Recommended margins range from 0.5 to 3.0 cm due to the highly invasive nature of the disease [2,3]. Nevertheless, local recurrence rates remain high ranging from 59% to 64% in the first one to two years.…”

Section: Journal Of Aesthetic and Reconstructive Surgery Issn 2472-1905mentioning

confidence: 99%

“…Nevertheless, local recurrence rates remain high ranging from 59% to 64% in the first one to two years. The use of Mohs surgery has also been described [3], but an advantage in local recurrence is unclear given the limited power and followup time reported by the authors. The role of lymph node biopsy has not been studied despite a 10-16% rate of distant metastasis [2][3][4].…”

Section: Journal Of Aesthetic and Reconstructive Surgery Issn 2472-1905mentioning

confidence: 99%

Pilomatrix Carcinoma: Case Report of a Rare Cutaneous Malignancy with Unique Reconstructive Considerations

B??R??

Richl²,

Nguyen³

et al. 2016

J Aesthet Reconstr Surg

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Unusual Cutaneous Malignancies

Peters¹,

Olencki²

2012

Textbook of Uncommon Cancer

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Management of Pilomatrix Carcinoma: A Case Report of Successful Treatment with Mohs Micrographic Surgery and Review of the Literature

Cited by 40 publications

References 74 publications

Pilomatrix carcinoma on the left side of the parotid region: A case report and review of the literature

Pilomatrix carcinoma on the left side of the parotid region: A case report and review of the literature

Pilomatrix Carcinoma: Case Report of a Rare Cutaneous Malignancy with Unique Reconstructive Considerations

Unusual Cutaneous Malignancies

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