Pigmented lesions in children: when to worry

Schaffer, Julie V.

doi:10.1097/mop.0b013e32825b0788

Cited by 59 publications

(30 citation statements)

References 96 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This finding is concordant with the medical literature, in fact most Spitz nevi are known to occur on the face and lower extremities. 6 There was no positivity for CD133 in all of the Spitz nevus cases. Moreover, all of the Spitz nevi behaved in a benign manner and did not recur.…”

Section: Immunohistochemical Stainingmentioning

confidence: 86%

“…5 Spitz nevus, previously named benign juvenile melanoma by Sophie Spitz, is a benign acquired proliferation of melanocytes, commonly presenting in childhood with histopathological features that sometimes overlap with those of malignant melanoma. 6,7 Klein et al 4 observed significant increases in the expression of the stem cell markers CD133, CD166 and nestin in primary and metastatic melanoma in comparison with their expression in banal nevi.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Expression of CD133+ cancer stem cells in childhood malignant melanoma and its correlation with metastasis

et al. 2010

View full text Add to dashboard Cite

Cancer stem cells expressing CD133 exist in a wide array of tumors and their identification in malignant melanoma may help refine classification, diagnosis and treatment. To study the correlation between CD133 expression in childhood melanoma and lymph node and/or visceral metastasis, we evaluated 12 cases of malignant melanoma and 12 control cases of Spitz nevus occurring in children. Double immunostaining with CD133 and Ki-67 was performed in the cases showing CD133 positivity. Three melanoma patients had lymph node metastasis and only one had multivisceral metastases; CD133 was positive only in these four patients. The Ki-67 index was lower in the CD133 þ cells in comparison with the CD133 À melanoma cells in three cases. We found no positivity for CD133 in all the Spitz nevi. CD133 þ cancer stem cell expression in childhood malignant melanoma might correlate with lymph node and/or visceral metastasis and may have a low proliferative Ki-67 index that might explain their chemoresistance.

show abstract

Section: Immunohistochemical Stainingmentioning

confidence: 86%

mentioning

confidence: 99%

Expression of CD133+ cancer stem cells in childhood malignant melanoma and its correlation with metastasis

et al. 2010

View full text Add to dashboard Cite

show abstract

“…28,29 Esta investigação sistematiza, a partir das observações dos pacientes no IPPMG e dos dados de literatura, elementos que podem auxiliar dermatologistas e pediatras no diagnóstico e acompanhamento dos portadores de NMC. …”

Section: Conclusãounclassified

Estudo clínico dos nevos melanocíticos congênitos na criança e no adolescente

Fernandes

Machado²

2009

An. Bras. Dermatol.

View full text Add to dashboard Cite

Resumo: FUNDAMENTOS: a classificação dos nevos melanocíticos congênitos (NMC) e a magnitude do risco de transformação em melanoma são ainda polêmicos. OBJETIVOS: Analisar o perfil dos NMC em crianças e adolescentes no IPPMG-UFRJ segundo sexo, cor, idade, tipo clínico, localização e evolução. MATERIAL E MÉTODOS: Estudo longitudinal de coorte retrospectivo e prospectivo de 1994 a 2007; amostra de demanda espontânea e referida. RESULTADOS: 30 crianças e 30 adolescentes apresentaram 74 NMC: 60,8% (pequenos), 27% (médios), 5,4% (grandes) e 6,7% (gigantes), sendo que 45,9% no sexo masculino e 54% no sexo feminino e 45,9% em brancos e 54,% em não brancos. Sexo e cor não influenciaram o tipo clínico. Dentre os pequenos e médios, 27,1% apresentaram-se no tórax e 23% na cabeça e pescoço; os grandes e gigantes no pólo cefálico, região cervical, linha média posterior e membros; 28,3% foram seguidos por mais de 10 anos, 47,3% entre três e nove anos e 24,3% por tempo inferior a três anos. Os NMC pequenos e médios se mantiveram inalterados; um grande e dois gigantes mostraram clareamento; nenhum caso desenvolveu melanoma. CONCLUSÃO: distribuição homogênea entre brancos/não brancos e sexo masculino/ feminino. O sexo e a cor não tiveram relação com o tipo clínico; os NMC pequenos predominaram com localização preferencial no tronco. Palavras-chave: Adolescente; Criança; Melanoma; Nevo pigmentado Abstract: BACKGROUND: The classification of the congenital melanocytic nevus (CMN) and the magnitude of the risk of transformation into melanoma are still controversal. OBJECTIVE: To analyse the profile of the CMN in the child and teenager at IPPMG-UFRJ according to sex, skin colour, age, clinical type, locations and evolution. METHODS: Longitudinal study of retrospective and prospective cohort from 1994 to 2007. Aleatoric sample from spontaneous or referal demand. Results: 30 children and 30 teenagers showed 74 nevi: 60,8% (small), 27% (medium), 5,4% (large) and 6,7% (giant); from these, 45,9% were in the male sex and 54% in the female sex. There were 45,9% in white and 54% in non-white. Sex and skin colour didn't influence the clinical type. Among the small and medium nevi, 27,1% were located in the trunk, 23% in the head and neck; the large and giant ones in the head, neck, back and limbs; 28,3% were attended for more than 10 years, 47,3% between three and nine years and 24,4% for a time below three years; the small and medium CMN kept unchanged. The fading of the lesion was observed in one large and in two giant CMN. No cases of melanoma were observed. CONCLUSION: An homogeneous distribution among white/non white and male/female; the sex and the ethnic group did not influence the clinical type; the small CMN was the most frequent clinical type mainly in the trunk.

show abstract

“…Epitheliod BN are a histologic subtype of nevi that are associated with the Carney complex in children, encompassing a triad of cardiac myxomas, skin hyperpigmentation and endocrine overactivity [54]. As a general rule, BN are benign in children; however, on exceedingly rare ocassions, a large, evolving, blue-black plaque may represent a primary or metastatic melanoma ('malignant blue nevus') [55][56][57].…”

Section: Blue Nevimentioning

confidence: 99%