Dermoscopy of nevi and melanoma in childhood

Brooks, Christine; Scope, Alon; Braun, Ralph P.; Marghoob, Ashfaq A.

doi:10.1586/edm.10.71

Cited by 5 publications

(3 citation statements)

References 95 publications

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“…Giant congenital melanocytic nevi (GCMN) generally have an area larger than 20 cm 2 , are associated with a hair‐like or verrucous texture, and are often accompanied by satellite lesions 1 . GCMN not only affect the appearance of the patient but also carry certain risks.…”

Section: Introductionmentioning

confidence: 99%

Two‐stage surgical treatment of giant congenital melanocytic nevus around the auricle

Dong

Song

Jiang

et al. 2020

J of Cosmetic Dermatology

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Background This study presents the results of complete excision of giant congenital melanocytic nevi (GCMN) on the auricle, forehead, or periorbital area combined with tissue expansion, and skin graft transplantation performed in two stages based on 10 years of experience. Aims To solve the giant congenital melanocytic nevi on the auricle, forehead, or periorbital area with two‐stage operation. Patients/Methods A total of 21 patients with GCMN were included in this study. The operation combined tissue expander and skin graft transplantation. Result All GCMNs were successfully and completely excised. No patient in the study group had experienced skin contraction or auricular deformation at 3 years after treatment. Conclusion Two‐stage operation is effective for removing GCMN on the auricle or face and can achieve good oncological and cosmetic results.

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Section: Introductionmentioning

confidence: 99%

Two‐stage surgical treatment of giant congenital melanocytic nevus around the auricle

Dong

Song

Jiang

et al. 2020

J of Cosmetic Dermatology

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“…CMN is caused by abnormal melanocyte differentiation, migration, and deposition in the dermis during the early stages of embryogenesis [2,3]. It is a distress to patients for two reasons: one is disfigurement, and the other is the increased risk of developing malignant melanoma [3,4], especially in individuals with giant congenital melanocytic nevi (GCMN; over 20 cm in diameter) [5]. Several genomic and proteomic studies have been performed to elucidate the mechanism of melanotumorigenesis arising from CMN.…”

Section: Introductionmentioning

confidence: 99%

Human giant congenital melanocytic nevus exhibits potential proteomic alterations leading to melanotumorigenesis

Kim

Kim²,

Song

et al. 2012

Proteome Sci

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BackgroundA giant congenital melanocytic nevus (GCMN) is a malformation of the pigment cells. It is a distress to the patients for two reasons: one is disfigurement, and the other is the possibility of malignant changes. However, the underlying mechanisms of the development of GCMN and melanotumorigenesis in GCMN are unknown. Hence, the aim of this study was to identify the proteomic alterations and associated functional pathways in GCMN.ResultsProteomic differences between GCMN (n = 3) and normal skin samples (n = 3) were analyzed by one-dimensional-liquid chromatography-tandem mass spectrometry Relative levels of the selected proteins were validated using western blot analysis. The biological processes associated with the abundance modified proteins were analyzed using bioinformatic tools. Among the 46 abundance modified proteins, expression of 4 proteins was significantly downregulated and expression of 42 proteins was significantly upregulated in GCMN compared to normal skin samples (p < 0.05). More importantly, 31% of the upregulated proteins were implicated in various cancers, with five proteins being specifically related with melanoma. The abundance modified proteins in GCMN were involved in the biological processes of neurotrophin signaling, melanosome, and downregulated of MTA-3 in ER-negative breast tumors. In particular, an increase in the expression of the 14-3-3 protein family members appeared to be associated with key cellular biological functions in GCMN. Western blot analysis confirmed the upregulation of 14-3-3epsilon, 14-3-3 tau, and prohibitin in GCMN.ConclusionThese findings suggest that GCMN exhibits potential proteomic alterations, which may play a role in melanotumorigenesis, and the significant alteration of 14-3-3 family proteins could be a key regulator of the biological pathway remodeling in GCMN.

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“…[ 2 ] The reticular pattern seen in dermoscopy correlates with the melanin in keratinocytes and/or melanocytes along the epidermal rete ridges and the globular pattern correlates with the nests of melanocytes seen on histopathology. [ 3 ] In atypical cases of NS, dermoscopy may reveal irregular pattern, structureless and hyperpigmented areas which can be biopsied to look for malignant changes. [ 1 ]…”

mentioning

confidence: 99%

Dermoscopy as a simple non-invasive tool for diagnosis and monitoring of extensive nevus spilus maculosus

Arora

Mathachan

Arora

et al. 2023

Indian Dermatol Online J

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Dermoscopy of nevi and melanoma in childhood

Cited by 5 publications

References 95 publications

Two‐stage surgical treatment of giant congenital melanocytic nevus around the auricle

Two‐stage surgical treatment of giant congenital melanocytic nevus around the auricle

Human giant congenital melanocytic nevus exhibits potential proteomic alterations leading to melanotumorigenesis

Dermoscopy as a simple non-invasive tool for diagnosis and monitoring of extensive nevus spilus maculosus

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