Pigmented calcifying cystic odontogenic tumor associated with compound odontoma: Report of a rare case and review

Abstract

Calcifying cystic odontogenic tumor (CCOT) is a rare lesion accounting for only 2% of all odontogenic cysts and tumors. CCOTs can occur alone or in association with other odontogenic tumors such as odontomas. Pigmented intraosseous odontogenic lesions are rare. Among them, pigmented CCOT is known to occur with greater frequency. Only six cases of combination of pigmentation CCOT associated with odontoma have been reported in the literature. We herein present such a rare case occurring in the maxillary anterior region in a 13-year-old female patient.

Calcifying odontogenic cyst associated with complex odontoma treated with a conservative approach: a case report / Cisto odontogênico calcificante associado a odontoma complexo tratado com abordagem conservadora: relato de caso

“…In addition to dentinoid tissue in the fibrous capsule, microscopic findings characteristic of COCs include cystic lining containing anucleated and slightly eosinophilic cells, called ghost cells, which may be calcified [1].…”

“…In other hypotheses, COCs were secondary to the odontogenic epithelium in the formation of the odontoma; however, the formation of the odontoma from the epithelial lining of the COC was also considered. In addition, they may be different clinical entities [1].…”

“…Calcifying odontogenic cysts (COCs) were previously described by Gorlin et al (1962) and Gold (1963). They are rare, usually unique lesions, accounting for about 1%-2% of odontogenic cysts and tumors [1], [2], [3]. Various terminologies have already been designated to refer to this lesion [1] that was reincorporated into the cyst session in the latest World Health Organization (WHO) classification for head and neck tumors in 2017 [4].…”

“…COCs occur alone or in association with other odontogenic tumors, such as ameloblastoma, adenomatoid odontogenic tumor (TOA), and ameloblastic fibroma [7]. In addition, it is related to dental tissue formation that resembles odontoma, an association most commonly reported [1].…”