Picosecond 532-nm neodymium-doped yttrium aluminium garnet laser—a novel and promising modality for the treatment of café-au-lait macules

Artzi, Ofir; Mehrabi, Joseph N; Koren, Amir; Niv, Roni; Lapidoth, Moshe; Levi, Assi

doi:10.1007/s10103-017-2373-9

Cited by 19 publications

(20 citation statements)

References 25 publications

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“…It can be located in various parts of the body. The common manifestations are usually oval patches (1 mm to 20 cm in size) with clear borders and regular rules 27. In our research, the deposit of melanin in skin increases and appears cobblestone pattern in the epidermis and density of ringed pattern without variation in size and shapes in the DEJ.…”

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confidence: 55%

In vivo reflectance confocal microscopy for evaluating common facial hyperpigmentation

Zeng

Qiu

Xiang

2019

Skin Research and Technology

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Background In clinical settings, atypical facial hyperpigmentation such as nevus of Ota, acquired bilateral nevus of Ota‐like macules (ABNOM), melasma, and café‐au‐lait spots are often missed and misdiagnosed. Summarizing in vivo reflectance confocal microscopy (RCM) features of the hyperpigmentation is helpful in the diagnosis of ambiguous lesions. Methods We recruited 196 patients referred for unequivocal facial hyperpigmentation, including 55 patients with nevus of Ota, 45 patients with ABNOM, 62 patients with melasma, and 34 patients with café‐au‐lait spots. The RCM images were evaluated at the epidermis, the dermis‐epidermis junction (DEJ), and the upper papillary dermis from both hyperpigmented patches and normal skin. Results In the superficial and middle dermis, 41 of 55 patients (74.5%) with nevus of Ota were characterized by a cord‐like or lumpy structure between the collagen fibers. And there was no melanin deposition detected in the dermis in 14 of 55 (25.5%) patients. In ABNOM, 37 of 45 (82.2%) patients were characterized by a cord‐like or lumpy structure in the superficial dermis and 8 of 45 patients (17.8%) was no melanin deposition detected in the dermis. The epidermis was no difference between nevus of Ota, ABNOM, and the normal skin. Melasma was detected increased cobblestone pattern in the epidermis of all patients, branching architecture in 21 of 62 patients (33.9%), and focally aggregated round to triangular cells in the upper dermis of 18 of 62 patients (29.0%). In all patients with afé‐au‐lait spots, increased cobblestone pattern in the epidermis and regular and increased density of ringed pattern in the DEJ were visualized. Conclusions Our findings indicate that RCM may be useful in the auxiliary diagnosis of nevus of Ota, ABNOM, melasma, and café‐au‐lait spots.

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confidence: 55%

In vivo reflectance confocal microscopy for evaluating common facial hyperpigmentation

Zeng

Qiu

Xiang

2019

Skin Research and Technology

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“…Picosecond lasers with wavelengths of 532, 755, and 1064 nm have been reported to be safe and effective in the treatment of a wide range of discrete pigmented lesions including solar lentigines, freckles, verrucus epidermal nevus, café au lait macules (CALM), nevus of Ota, and Hori's macules. A total of five case reports/series; five retrospective reviews; three prospective open-label trials; and four split-face/lesion randomized comparison trials involving a cumulative 320 subjects have documented these findings [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29].…”

Section: Discrete Pigmented Lesionsmentioning

confidence: 99%

“…The PIH rate between 5 and 10% as reported in the latter two studies is consistent with the authors' clinical experience, whereas the low rate of 1% seen by Guss et al may have been an underestimation due to the retrospective nature of their study, differences in methodology used to calculate PIH rate, and low sample size. CALM has been studied in one retrospective review involving 16 patients [17]. Artzi et al used a 375 picoseconds pulsed 532 nm frequency double Nd:YAG laser at 4-5 mm spot size and 0.8-1.6 J/cm 2 .…”

Section: Discrete Pigmented Lesionsmentioning

confidence: 99%

A Systematic Review of Picosecond Laser in Dermatology: Evidence and Recommendations

et al. 2020

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Background and Objectives The use of picosecond laser in dermatology was originally focused on optimizing the removal of unwanted tattoos. Subsequent advances in this technology have broadened its clinical indications to include treatment of benign pigmented lesions, photodamage, melasma, and scar revision. In this systematic review, evidence‐based recommendations are developed for the use of picosecond laser in dermatology. Study Design/Materials and Methods A comprehensive search of the English language literature was performed up to and including November 2019. Relevant citations were individually evaluated, synthesized, and categorized based on the Level of Evidence. With the addition of the authors’ combined clinical experience, clinical recommendations were developed. Results After application of inclusion and exclusion criteria, a total of 77 unique studies were evaluated. Treatment of benign pigmented lesions was associated with level I–IV evidence; rejuvenation was associated with level II evidence; melasma was associated with level II evidence; scar revision was associated with level II–III evidence; tattoo removal was associated with level I evidence. Conclusion Picosecond laser is a safe and effective treatment modality for an increasing range of dermatologic indications. Further development of this technology is warranted. Lasers Surg. Med. © 2020 Wiley Periodicals, Inc.

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“…PS lasers have been shown to be quite superior over other methods, including various Q‐switched (QS), Er:YAG, copper vapor, and pulse dye lasers . QS lasers were shown to exhibit dyspigmentation and even scarring, with variable recurrence.…”

Section: Discussionmentioning

confidence: 99%

“…The iconic feature of the PS laser is that its pulse duration is less than a nanosecond, achieving a photoacoustic effect and limiting the amount of thermal damage delivered to surrounding tissue . Aside from tattoo removal, PS lasers have been shown to be versatile and valuable in the treatment of various conditions such as lentigines, café‐au‐lait macules (CALMs), nevus of Ota, acne scarring, and skin rejuvenation . In this article, we report our experience treating a wide range of indications using a PS laser.…”

Section: Introductionmentioning

confidence: 99%

Retrospective photographic review of nontattoo indications treated by picosecond laser

Mehrabi

Friedman

Al‐Niaimi

et al. 2020

J of Cosmetic Dermatology

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Dermatology is a rapidly advancing field with many technologies added to the expanding armamentarium of the physician, particularly in the cosmetic sector of the specialty. Patients of all age groups and backgrounds seek treatment for skin conditions; these range from young adults with acne and acne scarring to the elderly requiring skin rejuvenation. energy-based devices (EBDs) are increasingly frequently used for the treatment of different aesthetic dermatological problems. Every technology offers a different mechanism of action, recovery timescale, and adverse effects. New technologies are becoming costlier, and this may have implications on the ratio of service to cost-effectiveness. A well-tolerated EBD procedure that can effectively treat different skin types and multiple skin conditions with minimal adverse effects and shortened downtime might be more economically attractive due to its versatility and favorability among patients and treating physicians alike.Picosecond (PS) lasers were approved by the US FDA in 2012 for the removal of tattoos. 1 The iconic feature of the PS laser is that its pulse duration is less than a nanosecond, achieving a photoacoustic effect and limiting the amount of thermal damage delivered to surrounding tissue. 2,3 Aside from tattoo removal, PS Abstract Background: Picosecond (PS) lasers were approved by the US FDA in 2012 after being shown to remove tattoos with more success and fewer treatments compared with traditional methods. PS lasers were shown to be versatile, indicated for the treatment of lentigines, café-au-lait macules (CALMs), and acne scars and skin rejuvenation. Objective:We report our experience treating our patients for different indications using a PS laser. Methods:We performed a retrospective chart and photographic review of all patients seen between 2016 and 2018 that were treated in our centers with a PS laser for nontattoo indications. Clinical outcomes were evaluated using side-by-side comparisons of the clinical photographs by two blinded, independent physicians using a visual analog scale consisting of six levels of treatment response. Results: A total of 233 patients were studied. Most sought treatment for solar lentigo (27%) and skin rejuvenation (14%). Epidermal nevi exhibited the greatest improvement with treatment, while acne scarring demonstrated the least. Only 24% of patients experienced noteworthy, transient adverse effects. Conclusion: Picosecond lasers were efficacious and safe for a variety of indications. They were effective in treating epidermal nevi and pigmented lesions, such as Lentigines and CALMs. K E Y W O R D S aesthetic improvement, epidermal nevus, laser treatment, picosecond laser, solar lentigines | 613 MEHRABI Et Al.

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Picosecond 532-nm neodymium-doped yttrium aluminium garnet laser—a novel and promising modality for the treatment of café-au-lait macules

Cited by 19 publications

References 25 publications

In vivo reflectance confocal microscopy for evaluating common facial hyperpigmentation

In vivo reflectance confocal microscopy for evaluating common facial hyperpigmentation

A Systematic Review of Picosecond Laser in Dermatology: Evidence and Recommendations

Retrospective photographic review of nontattoo indications treated by picosecond laser

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