Phytosterols, but not pectin, added to a high-saturated-fat diet modify saturated fatty acid excretion in relation to chain length

Brufau, Gemma; Canela, Miguel Ángel; Rafecas, Magda

doi:10.1016/j.jnutbio.2006.10.003

Cited by 8 publications

(10 citation statements)

References 35 publications

(50 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reducing reabsorption, as well as increased excretion of bile acids, improves the profile of cholesterolemic subjects [ 46 ]. A second possible mechanism would be to change the formation of micelles [ 47 ] contributing to the minimizing cholesterol absorption [ 48 ].…”

Section: Resultsmentioning

confidence: 99%

Antihypercholesterolemic Effects of Fruit Aqueous Extract of Copernicia prunifera (Miller) H. E. Moore in Mice Diet‐Induced Hypercholesterolemia

Paim

Benjamin

Rondina

et al. 2017

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

The present objective of the investigation is to evaluate the antihypercholesterolemic activity of the aqueous fruit pulp extract (APE) of Copernicia prunifera (Miller) H. E. Moore (Arecaceae family). Various chemical characterization methods like thin layer chromatography, Fourier transform infrared spectroscopy, 1H and 13C NMR, and molecular weight by gel permeation chromatography have been employed to characterize the extracted pectin. The present study demonstrated that hypercholesterolemic diet (HD) created hypercholesterolemia, caused significant increases in body weight, total cholesterol, and low-density lipoprotein, and caused decreases in high-density lipoprotein in serum compared with SD group. Two doses (APE 150 and 300 mg/Kg b.w./day) were administered to hyperlipidemic mice for 90 days. APE reversed body weight changes, changed serum lipids to normal values, and significantly inhibited the changes of lipid peroxidation and inflammation in the liver tissues. The renal parameters analyzed (urea and creatinine) altered by diet were reverted to normal values. Our results revealed that aqueous fruit pulp extracts of carnauba reduced hypercholesterolemia showing a potential preventive effect against cardiovascular diseases without side effects cause.

show abstract

Section: Resultsmentioning

confidence: 99%

Antihypercholesterolemic Effects of Fruit Aqueous Extract of Copernicia prunifera (Miller) H. E. Moore in Mice Diet‐Induced Hypercholesterolemia

Paim

Benjamin

Rondina

et al. 2017

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…This finding is mainly attributed to the low digestibility of these FA [22]. The FA profile in feces was not altered by PHGG consumption in a similar way to other dietary fibers such as pectin [23] and in contrast to others such as hydroxypropyl methylcellulose [14].…”

Section: Discussionmentioning

confidence: 78%

Partially Hydrolyzed Guar Gums Reduce Dietary Fatty Acid and Sterol Absorption in Guinea Pigs Independent of Viscosity

Santas

Espadaler

Cuñé

et al. 2012

Lipids

Self Cite

View full text Add to dashboard Cite

This study investigated the effect of two partially hydrolyzed guar gums (PHGG) on fatty acid and sterol excretion. PHGG were obtained by chemical hydrolysis of guar gum (GG) with H(2)O:EtOH (1:1) at 100 °C for 1 h (PHGG1) or 2 h (PHGG2). The viscosity of the PHGG in a 1 % (w/v) aqueous solution corresponded to that of a pseudoplastic fluid and was higher for PHGG1 than PHGG2. Guinea pigs (n = 8 per group) were fed high fat diets (17/100 g) that contained 12/100 g of cellulose, PHGG1, or PHGG2 for 4 weeks. Despite the differences in viscosity, the two PHGG exerted similar physiological effects. Compared to the control cellulose group, the body weight gain was lower in animals fed PHGG, although no effect on food consumption was observed. PHGG increased the excretion of fatty acids and neutral sterols, but not bile acids. Consumption of PHGG did not alter the fecal fatty acid profile, while intestinal bioconversion of sterols tended to increase in response to PHGG2. A reduction in the viscosity within the range tested did not correlate with losses in the hypocholesterolemic capacity of PHGG as both were effective in reducing plasma cholesterol. Thus, we conclude that the chemical hydrolysis of guar gum renders the gum suitable for inclusion in food products without significantly altering its beneficial health effects.

show abstract

“…In the present study, we evaluated the hypolipidemic activity of a polysaccharide-rich composition extracted from the cell wall of S. cerevisiae which has been reported to contain a specific b-glucan-chitin-chitosan fraction and proposed to reduce fat bioavailability [12]. For comparative purposes, commercially available oat bran (Avena sativa L.) was included in the study as a common source of dietary fiber, particularly b-glucan [10], and cellulose was used as negative control as it is known to have a neutral effect on lipid metabolism [5]. High-fat diets were used in the present study to minimize dissimilarities in dietary fat intake due to the inclusion of fiber sources with different nutrient composition.…”

Section: Discussionmentioning

confidence: 99%

“…Epidemiological studies demonstrate a clear association between obesity and cardiovascular diseases (CVD) and a sedentary lifestyle, high intake of saturated fats and sugars, and low intakes of fruits and vegetables . Thus, dietary interventions implying a reduction of fat ingestion and/or its bioavailability and an increase in dietary fiber ingestion are among the primary options for prevention and treatment .…”

Section: Introductionmentioning

confidence: 99%

“…Thus, the present research was focused on the study of the excretion of neutral (i.e., cholesterol and its secondary metabolites) and acidic sterols (i.e., primary and secondary bile acids), and particularly on individual fatty acids (FA), given that the sterol and FA composition of dietary fat may result in different effects on lipid metabolism . The study was conducted with guinea pigs, an established animal model because of its similarities to human in lipid metabolism and its responses to dietary treatment in terms of cholesterol concentrations .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Polysaccharide‐rich hydrolysate from Saccharomyces cerevisiae (LipiGo^®) increases fatty acid and neutral sterol excretion in guinea pigs fed with hypercholesterolemic diets

Santas¹,

Rafecas

Cuñé³

2017

Euro J Lipid Sci & Tech

Self Cite

View full text Add to dashboard Cite

This study aimed to evaluate the hypolipidemic properties of a polysaccharide‐rich hydrolysate from Saccharomyces cerevisiae comprising β‐glucan‐chitin‐chitosan (BCC). Guinea pigs (n = 8 per group) were fed high‐fat and hypercholesterolemic diets (17 g/100 g of fat, 0.2 g/100 g of cholesterol), containing 12 g/100 g of either cellulose (CEL) as negative control, oat bran as a source of β‐glucan (BOB), or BCC. Food intake and body weight were monitored for 4 weeks and fatty acid (FA), neutral sterol (NS), and bile acid (BA) excretion were determined. BCC, but not BOB, reduced body weight gain and plasma total and LDL‐cholesterol, without altering food consumption. This effect correlated well with the capacity of BCC to reduce apparent FA absorption (78.36 ± 7.41 vs. 89.51 ± 3.93% in control group), mainly due to an increase of saturated fatty acid (SFA) excretion and, to a lower extent of monounsaturated fatty acids (MUFA). NS excretion was also increased by BCC, although no effects were observed on BA excretion. Therefore, results suggest that the hypolipidemic effect of BCC can be mainly ascribed to its capacity to increase FA and NS excretion. Practical applications: This research provides evidence on the hypolipidemic effect and mechanism of action of Lipigo®, a polysaccharide‐rich hydrolysate from Saccharomyces cerevisiae comprising β‐glucan‐chitin‐chitosan (BCC). Particularly, results show that BCC can effectively increase the excretion of saturated fatty acids (SFA) and neutral sterols (NS), having a beneficial effect on plasma lipids. This information can be of interest for the development of food supplements in the field of diseases associated with high fat intake such as cardiovascular diseases and obesity. Supplementation of hypercholesterolemic diets with a polysaccharide‐rich hydrolysate from Saccharomyces cerevisiae comprising β‐glucan‐chitin‐chitosan increases the excretion of saturated and monounsaturated fatty acids and neutral sterols compared to cellulose. This effect is consistent with a reduction in body weight gain and plasma total and LDL‐cholesterol.

show abstract

Phytosterols, but not pectin, added to a high-saturated-fat diet modify saturated fatty acid excretion in relation to chain length

Cited by 8 publications

References 35 publications

Antihypercholesterolemic Effects of Fruit Aqueous Extract of Copernicia prunifera (Miller) H. E. Moore in Mice Diet‐Induced Hypercholesterolemia

Antihypercholesterolemic Effects of Fruit Aqueous Extract of Copernicia prunifera (Miller) H. E. Moore in Mice Diet‐Induced Hypercholesterolemia

Partially Hydrolyzed Guar Gums Reduce Dietary Fatty Acid and Sterol Absorption in Guinea Pigs Independent of Viscosity

Polysaccharide‐rich hydrolysate from Saccharomyces cerevisiae (LipiGo^®) increases fatty acid and neutral sterol excretion in guinea pigs fed with hypercholesterolemic diets

Contact Info

Product

Resources

About

Phytosterols, but not pectin, added to a high-saturated-fat diet modify saturated fatty acid excretion in relation to chain length

Cited by 8 publications

References 35 publications

Antihypercholesterolemic Effects of Fruit Aqueous Extract of Copernicia prunifera (Miller) H. E. Moore in Mice Diet‐Induced Hypercholesterolemia

Antihypercholesterolemic Effects of Fruit Aqueous Extract of Copernicia prunifera (Miller) H. E. Moore in Mice Diet‐Induced Hypercholesterolemia

Partially Hydrolyzed Guar Gums Reduce Dietary Fatty Acid and Sterol Absorption in Guinea Pigs Independent of Viscosity

Polysaccharide‐rich hydrolysate from Saccharomyces cerevisiae (LipiGo®) increases fatty acid and neutral sterol excretion in guinea pigs fed with hypercholesterolemic diets

Contact Info

Product

Resources

About

Polysaccharide‐rich hydrolysate from Saccharomyces cerevisiae (LipiGo^®) increases fatty acid and neutral sterol excretion in guinea pigs fed with hypercholesterolemic diets