Phytomelatonin: a potential phytotherapeutic intervention on COVID-19-exposed individuals

Okeke, Emmanuel Sunday; Ogugofor, Martins Obinna; Nkwoemeka, Ndidi Ethel; Nweze, Ekene John; Okoye, Charles Obinwanne

doi:10.1016/j.micinf.2021.104886

Cited by 9 publications

(3 citation statements)

References 90 publications

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“…Also noteworthy are the studies on melatonin’s anti-oncogenic role in many tumors as a sensitizer in chemical and radiological therapies. Moreover, its therapeutic efficacy in Parkinson’s and Alzheimer’s disease as well as in COVID-19 has also been studied [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Melatonin in Brassicaceae: Role in Postharvest and Interesting Phytochemicals

et al. 2022

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Brassicaceae plants are of great interest for human consumption due to their wide variety and nutritional qualities. Of the more than 4000 species that make up this family, about a hundred varieties of 6–8 genera are extensively cultivated. One of the most interesting aspects is its high content of glucosinolates, which are plant secondary metabolites with widely demonstrated anti-oncogenic properties that make them healthy. The most relevant Brassicaceae studies related to food and melatonin are examined in this paper. The role of melatonin as a beneficial agent in seedling grown mainly in cabbage and rapeseed and in the postharvest preservation of broccoli is especially analyzed. The beneficial effect of melatonin treatments on the organoleptic properties of these commonly consumed vegetables can be of great interest in the agri-food industry. Melatonin application extends the shelf life of fresh-cut broccoli while maintaining optimal visual and nutritional parameters. In addition, an integrated model indicating the role of melatonin on the organoleptic properties, the biosynthesis of glucosinolates and the regulatory action of these health-relevant compounds with anti-oncogenic activity is presented.

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Section: Introductionmentioning

confidence: 99%

Melatonin in Brassicaceae: Role in Postharvest and Interesting Phytochemicals

et al. 2022

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“…), sleep disorders (jet-lag, insomnia, delayed sleep-phase, night-shift work sleep, sleep quality in blindness and autism), and others such as gastrointestinal, cardiovascular, in pre- and post-operative stress. Currently, research focuses on its role as an adjuvant in radio- and chemotherapies against several types of cancer, its role in neuro-dysfunctions such as Alzheimer’s and Parkinson’s, in diabetes and metabolic syndrome, and in immunological diseases, and its role as a relevant anti-inflammatory agent, having been proposed as a therapy against SARS-CoV-2 [ 74 , 75 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 ].…”

Section: Melatoninmentioning

confidence: 99%

Essential Oils and Melatonin as Functional Ingredients in Dogs

Ruiz-Cano¹,

Sánchez-Carrasco²,

Mihyaoui

et al. 2022

Animals

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The use of nutraceuticals or functional ingredients is increasingly widespread in human food; their use is also widespread in animal feed. These natural compounds generally come from plant materials and comprise a wide range of substances of a very diverse chemical nature. In animals, these compounds, so-called phytogenics, are used to obtain improvements in feed production/stability and also as functional components with repercussions on animal health. Along with polyphenols, isoprenoid compounds represent a family of substances with wide applications in therapy and pet nutrition. Essential oils (EOs) are a group of complex substances with fat-soluble nature that are widely used. Melatonin is an indolic amine present in all living with amphiphilic nature. In this work, we present a review of the most relevant phytogenics (polyphenol, isoprenoid, and alkaloid compounds), their characteristics, and possible uses as nutraceuticals in dogs, with special emphasis on EOs and their regulatory aspects, applied in foods and topically. Additionally, a presentation of the importance of the use of melatonin in dogs is developed, giving physiological and practical aspects about its use in dog feeding and also in topical application, with examples and future projections. This review points to the combination of EOs and melatonin in food supplements and in the topical application as an innovative product and shows excellent perspectives aimed at addressing dysfunctions in pets, such as the treatment of stress and anxiety, sleep disorders, alopecia, and hair growth problems, among others.

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“…Numerous roles have been proposed for melatonin in mammals, such as the regulator of sleep cycles [ 9 ], sexual behavior [ 10 ], endocrine rhythms [ 11 , 12 , 13 ], amongst others. More recently, its implications have been shown in glucose metabolism and insulin [ 14 , 15 , 16 ], as a sensitizer in anti-oncogenic therapies [ 17 ], its positive effects in Parkinson’s and Alzheimer’s diseases [ 18 ], and its therapeutic efficiency in COVID-19 treatment [ 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Melatonin in Broccoli Postharvest and Possible Melatonin Ingestion Level

Caño

Giraldo-Acosta

García-Sánchez

et al. 2022

Plants

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The post-harvest stage of broccoli production requires cold storage to obtain enough days of shelf life. It has been proved that melatonin is useful as a post-harvest agent in fruits and vegetables, including broccoli. In this study, the broccoli heads treated with melatonin have a longer shelf life than the control samples, which was reflected in parameters such as fresh weight, hue angle (expresses color quality), and chlorophyll and carotenoid contents. Treatments with 100 μM melatonin for 15 or 30 min seem to be the most appropriate, extending the broccoli’s shelf life to almost 42 days, when it is normally around 4 weeks. In addition, a study on the possible impact that melatonin treatments in broccoli could have on melatonin intake in humans is presented. The levels of superficial melatonin, called washing or residual melatonin, are measured, showing the possible incidence in estimated blood melatonin levels. Our results suggest that post-harvest treatments with melatonin do not have to be a handicap from a nutritional point of view, but more research is needed.

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Phytomelatonin: a potential phytotherapeutic intervention on COVID-19-exposed individuals

Cited by 9 publications

References 90 publications

Melatonin in Brassicaceae: Role in Postharvest and Interesting Phytochemicals

Melatonin in Brassicaceae: Role in Postharvest and Interesting Phytochemicals

Essential Oils and Melatonin as Functional Ingredients in Dogs

Effect of Melatonin in Broccoli Postharvest and Possible Melatonin Ingestion Level

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