Phytomedicine in Otorhinolaryngology and Pulmonology: Clinical Trials with Herbal Remedies

Ghazi-Moghadam, Koosha; Inançli, Hasan Mete; Bazazy, Nazanin; Plinkert, Peter K.; Efferth, Thomas; Sertel, Serkan

doi:10.3390/ph5080853

Cited by 20 publications

(18 citation statements)

References 84 publications

(97 reference statements)

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“…In this regard, multiple studies have been performed in Iran and other countries around the world, investigating the administration of herbal medicine, including Rumex patientia , Ecballium elaterium , Stachys schtschegleevii , and Pelargonium sidoides , for this disease (Chitsaz, Mohammadi, & Kamalinejad, ; Ghazi‐Moghadam et al, ; Suleyman et al, ). Because studies on different medicinal plants have yielded different results in the treatment of CRS and because comprehensive systematic studies have not recently been conducted in rhinosinusitis, the aim of the current study was to assess and analyze randomized clinical trials (RCTs) in relation to the effects of medicinal plants on CRS.…”

Section: Introductionmentioning

confidence: 99%

A systematic review of randomized controlled trials with herbal medicine on chronic rhinosinusitis

Anushiravani

Bakhshaee

Taghipour

et al. 2017

Phytotherapy Research

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Chronic rhinosinusitis (CRS) is a common disease with evidence to show that its incidence and prevalence are increasing. Medicinal plants are commonly used to treat CRS. This systematic review aimed to assess the effectiveness and safety of herbal preparations for treatment of the patients with CRS. Cochran, Embase, ISI, PubMed, and Scopus databases were searched until August 1, 2016. Only randomized controlled trials were included. Four randomized controlled trials were included in this systematic review. Various medicinal plants were studied in each article. Inclusion and exclusion criteria, and outcome measures varied among different articles. The results of this trials showed that this special medicinal plants may be effective in the treatment of CRS. No serious reactions were reported during the administration of herbal remedies in the 4 studies. However, trials with a well-designed approach are needed to study the actual safety and efficacy of herbs in the treatment of CRS.

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Section: Introductionmentioning

confidence: 99%

A systematic review of randomized controlled trials with herbal medicine on chronic rhinosinusitis

Anushiravani

Bakhshaee

Taghipour

et al. 2017

Phytotherapy Research

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“…Cough is one of the most frequent complications of a cold, especially in children (1). Herbal compounds and other non-chemical agents are frequently used for symptom relief as an alternative option for patients with a poor response to conventional drugs (2). In the United States, there is a public trend toward the use of these agents for cough or cold (3).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Zataria multiflora Extract Syrup and Diphenhydramine in the Treatment of Common Cold-Induced Cough in Children: A Double-Blind, Randomized, Clinical Trial

Hosseini¹,

Hossein²,

Amanati³

et al. 2016

Arch Pediatr Infect Dis

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Background: Management of cold-associated cough is a challenging aspect of supportive care for the common cold for pediatricians and parents worldwide. Herbal compounds have traditionally been used for the treatment of cold-related cough. Among these compounds, Zataria multiflora (ZM) has been found to be effective for cough relief. Objectives: The aim of this study is to compare a thyme mixture with diphenhydramine in the treatment of cold-related cough in a double-blind, randomized, clinical trial. Patients and Methods: A total of 52 pediatric patients (2 -12 years old) with common colds were included in the study. The patients were randomly divided into two treatment groups: one group received diphenhydramine compound and the other received ZM syrup, each for five days. The severity of cold-related symptoms and the efficacy of each drug were determined seven days later by asking the parents to complete a prepared questionnaire. sedation, sleepiness, a four-point scale of cough status, and a two-point scale of consumption convenience were also evaluated in these questionnaires. Results: Our results showed that sedation and sleepiness occurred in 30.8% and 19.2% of the patients in the diphenhydramine and ZM groups, respectively (P = 0.54). Also, 65.4% and 84.6% of the patients in the diphenhydramine and ZM groups, respectively, reported convenient usage (P = 0.10). The patients who received ZM syrup had significantly better outcomes (P = 0.036). Conclusions: Herbal compounds, such as ZM mixtures, are acceptably efficacious in cough relief with fewer adverse effects than chemical compounds in the treatment of cold-related cough, especially in infants and younger children.

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“…Unfortunately, all current and even emerging treatment options are intended to ease one or several clinical symptoms often in association with other therapies including saline nasal washes, topical or oral antibiotics, nasal decongestants, steroids and anti-inflammatory drugs [13]. New emerging options include antimycotics, anti-IgE, anti-IL5, new antihistamines, complementary and alternative medicine, immunosuppressant medications, leukotriene inhibitors, phytotherapy, probiotics and proton pump inhibitors [15][16][17][18][19][20][21][22]. Despite such abundance of treatments available one wonders why none of them is really working and why even today, we don't have a cure for CRS.…”

Section: Discussionmentioning

confidence: 99%

“…A few patients of this study complained about moderate nasal irritation right after each TP application, lasting for about [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] seconds. This may be attributable to the fact that FPG solution is osmotic and draws intracellular hypotonic liquid as soon as it is sprayed as a film over the nasal mucosa.…”

Section: Discussionmentioning

confidence: 99%

Clinical Efficacy of a New Filmogen Polymeric Glycerol Solution for the Treatment of Rhinosinusitis

Rm¹,

Tourret²,

Schütte³

et al. 2017

J Clin Respir Dis Care

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Study background: The main cause of chronic rhinosinusitis is not yet well understood but increasing amount of evidence suggest an initial viral attack followed by secondary bacterial infection leading to the formation of a wellprotected reservoir of microorganisms in the sinuses where no treatment can easily reach. The efficacy of a new, non-irritant and moderately osmotic, polymeric glycerol filmogen solution was evaluated clinically.Methods: A 14-day, randomized, placebo-controlled, double blind, efficacy and safety clinical study was conducted with participation of thirty-eight patients treated with the filmogen polymeric glycerol vs. saline solution as comparator treatment used on sixteen control patients. Two to three nasal sprays were applied, three times daily over maximum fourteen days. Effects on rhinorrhea, nasal congestion, headache, facial pain, and sino-nasal outcome test were evaluated.Results: Rhinorrhea was much stronger in the test product group during the 1st three days compared to comparator and decreased drastically thereafter. Severity of all other rhinosinusitis symptoms also diminished in both groups but the reduction was much faster and stronger in the test group compared to comparator group (p<0.05), and led to minimized requirement for antibiotics. The test product was non-irritant and totally safe, no adverse effects being observed. Conclusion:Treating rhinosinusitis with a moderately osmotic solution capable of generating positive osmotic pressure yet non-irritant polymeric film constitutes a major breakthrough in the treatment of Rhinosinusitis.

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Phytomedicine in Otorhinolaryngology and Pulmonology: Clinical Trials with Herbal Remedies

Cited by 20 publications

References 84 publications

A systematic review of randomized controlled trials with herbal medicine on chronic rhinosinusitis

A systematic review of randomized controlled trials with herbal medicine on chronic rhinosinusitis

Comparison of Zataria multiflora Extract Syrup and Diphenhydramine in the Treatment of Common Cold-Induced Cough in Children: A Double-Blind, Randomized, Clinical Trial

Clinical Efficacy of a New Filmogen Polymeric Glycerol Solution for the Treatment of Rhinosinusitis

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