A systematic review of randomized controlled trials with herbal medicine on chronic rhinosinusitis

Anushiravani, Majid; Bakhshaee, Mehdi; Taghipour, Ali; Naghedi-Baghdar, Hamideh; Farshchi, Masoumeh Kaboli; Hoseini, Seyed Saeed; Mehri, Mohammad Reza

doi:10.1002/ptr.5968

Cited by 17 publications

(10 citation statements)

References 27 publications

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“…Xanthium powder, which comes from Ji Sheng Fang of song dynasty, is the basic and classic prescription for treating nasitis.Randomized controlled trials showed that the Chinese herbal medicine compound Xanthium powder and Houttuynia cordata were similar to macrolide in the treatment of CRS. At the same time, this study also found that Gegen Decoction and Longdan Xiegan decoction had antiviral effect on torhinolaryngologic diseases [5][6].It was con rmed that [7] herbal dry extract BNO 1011 could increase the clearance rate of mucociliary by up regulating the culture of nasal cavity in vitro and Cl-secretion of mouse epithelial cells in vivo.…”

Section: Introductionsupporting

confidence: 56%

Chinese herbal medicine for the treatment of chronic rhinosinusitis: protocol for a systematic review and meta-analysis

Hu¹,

L²,

Zhu³

et al. 2020

Preprint

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Background: In east Asian countries, the traditional treatment is to treat chronic rhinosinusitis(CRS) with some herbal formulas. However, there is a lack of clinical evidence to support the effect of the drug. Here, we describe a randomized controlled trial to investigate the efficacy and safety of herbal formulations for the treatment of CRS.Methods: We will search electronic databases including the Cochrane Central Register of Controlled Trials (CENTRAL), Chinese Biomedical Literature Database (CBM), PubMed, Embase, Chinese Science and Technology Periodical Database (VIP), China National Knowledge Infrastructure (CNKI), and Wanfang database using keywords related to CRS and Chinese herbal medicine. Extensive database search was carried out for CRS related randomized controlled trials.Two reviewers(SH and LL) will independently filter the search results to determine eligible articles, complete data collection.The quality of individual trials will be assessed by(XZ and YF) using the Cochrane collaborative bias risk assessment tool. We will calculate the relative risk and 95% confidence interval(CI) of the dichotomy results and the weighted average difference, as well as the corresponding 95% confidence interval of the continuous results. Statistical methods such as subgroup analysis and sensitivity analysis will be used to investigate the sources of heterogeneity.Discussion: The systematic review and meta-analysis will provide evidence for the quality of life and the safety of traditional Chinese medicine in CRS patients.This study will provide a high quality research method for the therapeutic effect of Chinese herbal medicine on CRS, and will also help broaden research horizons for the complementary and alternative therapy of CRS.Systematic review registrationPROSPERO registration number: CRD42019123047(https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42019123047).

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Section: Introductionsupporting

confidence: 56%

Chinese herbal medicine for the treatment of chronic rhinosinusitis: protocol for a systematic review and meta-analysis

Hu¹,

L²,

Zhu³

et al. 2020

Preprint

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“…In total, 80 RCTs were included in this review. Two previous systematic reviews that summarized the effects of HM on CRS treatment have been published ( Guo et al, 2006 ; Anushiravani et al, 2018 ); however, these did not search local databases of East Asian countries where HM is actively used. Only 4 and 10 studies were included, respectively, and a sufficiently comprehensive search was not conducted.…”

Section: Discussionmentioning

confidence: 99%

“…However, this review was focused on both acute and chronic patients and did not include local databases such as those of Korea, China, and Japan, so the effect of HM could not be evaluated comprehensively. In addition, although another systematic review was conducted in 2018 that examined the effectiveness of HM in CRS, it also had the limitation that the database search did not include local databases of East Asian countries where EATM is commonly used ( Anushiravani et al, 2018 ). Given that it is recommended to include databases of traditional medicine when searching for studies of EATM modalities, such as HM or acupuncture, a systematic review on this topic needs to be further strengthened ( Wang et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Herbal medicine for the treatment of chronic rhinosinusitis: A systematic review and meta-analysis

2022

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Objectives: Chronic rhinosinusitis (CRS) is a disease with a high prevalence and a high socioeconomic burden. This study aimed to conduct a comprehensive systematic review to update the evidence on the use of herbal medicine (HM) for CRS treatment.Methods: A total of 14 electronic databases for randomized controlled trials (RCTs) evaluating the effects of HM on the treatment of CRS were searched for articles published before July 2021. The primary outcome was CRS severity post-treatment, measured with the Visual Analogue Scale (VAS) and Total Effective Rate (TER). The risk of bias of the included studies and the quality of evidence of the main findings were assessed using the Cochrane Collaboration’s risk of bias tool and the Grading of Recommendations, Assessment, Development, and Evaluations tool.Results: A total of 80 RCTs were included. Compared to placebo, HM significantly improved CRS severity as measured by TER and VAS. When HM was compared with conventional treatment (CT) as monotherapy or adjuvant therapy, CRS severity measured by TER and VAS, quality of life, Lund-Kennedy endoscopy score, Lund-Mackay computed tomography score, and nasal mucociliary function were significantly improved in the HM group. No serious adverse events associated with HM were reported. The risk of bias was generally unclear, and the quality of evidence ranged from moderate to low.Conclusion: This review found some limited clinical evidence that HM or HM combined with CT may be more effective and safer than CT alone in treating CRS. However, the methodological quality of the included studies was generally low, and the quality of the evidence needs to be improved.

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“…However, these medications act only as dietary supplements and are unable to preserve the kidney function [4]. Therefore, healthcare professionals continuously seek alternative therapies such as herbal remedies owing to their efficiency, availability, and fewer side effects [5].…”

Section: Introductionmentioning

confidence: 99%

In vitro anti-nephrotoxic potential of Ammi visnaga, Petroselinum crispum, Hordeum vulgare, and Cymbopogon schoenanthus seed or leaf extracts by suppressing the necrotic mediators, oxidative stress and inflammation

Abu‐Serie

Habashy

Maher

2019

BMC Complement Altern Med

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Background The kidney is an essential organ required by the body to perform several important functions. Nephrotoxicity is one of the most prevailing kidney complications that result from exposure to an extrinsic or intrinsic toxicant, which increase the need for the acquisition of proper remedies. Recently, natural remedies are gaining great attention owed to the fact that they have fewer side effects than most conventional drugs. Methods The current study recorded a new therapeutic role of the well-known medicinal plants for kidney stones [ Ammi visnaga (AVE), Petroselinum crispum (PCE), Hordeum vulgare (HVE), and Cymbopogon schoenanthus (CSE)]. Hence, the aqueous extracts of these plants examined against CCl 4 -induced toxicity in mammalian kidney (Vero) cells. Results These extracts showed the presence of varying amounts of phenolic and triterpenoid compounds, as well as vitamin C. Owing to the antioxidant potential of these constituents, the extracts suppressed the CCl 4 -induced oxidative stress significantly ( p < 0.05) by scavenging the reactive oxygen species and enhancing the cellular antioxidant indices. In addition, these extracts significantly ( p < 0.05) reduced the CCl 4 -induced inflammation by inhibiting the gene expression of NF-кB, iNOS, and in turn the level of nitric oxide. Consequently, the morphological appearance of Vero cells, cellular necrosis, and the gene expression of kidney injury molecule-1 (a marker of renal injury) after these treatments were improved. The AVE improved CCl 4 -induced oxidative and inflammatory stress in Vero cells and showed a more potent effect than the commonly used alpha-Ketoanalogue drug (ketosteril) in most of the studied assays. Conclusion Thus, the studied plant extracts, especially AVE can be considered as promising extracts in the management of nephrotoxicity and other chronic diseases associated with oxidative stress and inflammation. Graphical abstract

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A systematic review of randomized controlled trials with herbal medicine on chronic rhinosinusitis

Cited by 17 publications

References 27 publications

Chinese herbal medicine for the treatment of chronic rhinosinusitis: protocol for a systematic review and meta-analysis

Chinese herbal medicine for the treatment of chronic rhinosinusitis: protocol for a systematic review and meta-analysis

Herbal medicine for the treatment of chronic rhinosinusitis: A systematic review and meta-analysis

In vitro anti-nephrotoxic potential of Ammi visnaga, Petroselinum crispum, Hordeum vulgare, and Cymbopogon schoenanthus seed or leaf extracts by suppressing the necrotic mediators, oxidative stress and inflammation

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