Herbal medicine for the treatment of chronic rhinosinusitis: A systematic review and meta-analysis

Lee, Boram; Kwon, Chan-Young; Park, Man Young

doi:10.3389/fphar.2022.908941

Cited by 3 publications

(4 citation statements)

References 82 publications

(68 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the experimental group, treatment was ineffective for 4 patients, potentially because of the presence of inflammation involving multiple paranasal sinuses in these patients, presenting a relatively wide scope of inflammation. For such patients, herbal medicine combined with conventional treatment may be more effective than herbal alone ( 18 ). The resolution of 2 cases in the placebo group may be related to taking dextromethorphan as needed.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of Sanfeng Tongqiao Diwan in the treatment of upper airway cough syndrome: a randomized, double-blind, placebo-controlled clinical study

Wang¹,

Xian²,

Xu³

et al. 2023

J Thorac Dis

View full text Add to dashboard Cite

Background: Sanfeng Tongqiao Diwan has shown the potential to alleviate acute, recurrent, and chronic rhinitis in adults based on available studies. However, the evidence for its application in upper airway cough syndrome (UACS) is unclear. The purpose of this study was thus to investigate the efficacy and safety of Sanfeng Tongqiao Diwan in the treatment of UACS.Methods: This was a single-center, randomized, double-blind, placebo-controlled clinical trial. A total of 60 patients who satisfied the inclusion criteria were randomly divided into experimental and placebo groups in a 1:1 ratio. The experimental group was given Sanfeng Tongqiao Diwan, and the placebo group was given a simulant for 14 consecutive days. The follow-up period was 15 days. The primary outcome was the total effective rate. The secondary outcomes included clinical efficacy, visual analogue scale (VAS) of related symptoms, and Leicester Cough Questionnaire in Mandarin-Chinese (LCQ-MC) scores before and after the treatment. Additionally, the safety was also evaluated. Results:The total effective rate in the experimental group was 86.6% (26/30), which was significantly higher than the 7.1% (2/28) in the placebo group (difference 79.6; 95% CI: 57.0 to 89.1; P<0.001). Nasal congestion, runny nose, cough, postnasal drip, and overall symptoms in the experimental group were significantly lower than those in the placebo group after treatment (3.7±1.5 vs. 5.0±1.1, 3.6±1.3 vs. 5.9±1.1, 3.8±1.2 vs. 6.8±1.3, 3.5±1.4 vs. 6.1±1.5, 3.8±2.0 vs. 7.3±1.4, respectively; all P values <0.001). After treatment, the LCQ-MC score in the experimental group was significantly higher than that in the placebo group (all P values <0.001). The blood eosinophil count in the placebo group was significantly higher after treatment than before treatment (P=0.037). No abnormalities were found in liver or renal indicators during the treatment period in the 2 groups, and no adverse reactions occurred.Conclusions: Sanfeng Tongqiao Diwan improved the symptoms and living quality of patients with UACS and showed acceptable safety. The results of this trial represent rigorous clinical evidence for the application of Sanfeng Tongqiao Diwan and further support a new option in UACS treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of Sanfeng Tongqiao Diwan in the treatment of upper airway cough syndrome: a randomized, double-blind, placebo-controlled clinical study

Wang¹,

Xian²,

Xu³

et al. 2023

J Thorac Dis

View full text Add to dashboard Cite

show abstract

“…Zur Wirksamkeit und Sicherheit von Phytotherapie existieren verschiedene systematische Reviews und Metaanalysen 4 5 6 7 8 . Im Folgenden wird ein Einblick in die internationale Forschungslandschaft gegeben und es werden exemplarisch Empfehlungen der EMA und medizinischer Leitlinien angeführt.…”

Section: Hintergrundunclassified

“…Die Nutzung von Phytotherapie zur Behandlung von akuten Atemwegsinfekten hat sich etabliert. Als Gegenstand von verschiedenen Metaanalysen, medizinischen Leitlinien und Arbeiten der EMA haben sich verschiedene Phytotherapeutika als eine sichere Behandlungsoption für Erkältungen und Husten sowohl bei Kindern als auch bei Erwachsenen erwiesen 5 6 7 17 . Die Ergebnisse bestätigen die traditionelle Anwendung von Pflanzenextrakten bei der Linderung von Symptomen und Steigerung des Wohlbefindens.…”

Section: Fazitunclassified

Phytotherapie bei akuten Atemwegsinfekten – ein Überblick

Koch,

Langhorst

2024

Zeitschrift für Phytotherapie

View full text Add to dashboard Cite

ZusammenfassungEinige medizinische AWMF-Leitlinien empfehlen die Integration von Phytotherapie in der Behandlung von Atemwegserkrankungen. Auch die European Medicines Agency (EMA) spricht sich positiv zur Anwendung bestimmter Phytotherapeutika bei Atemwegsinfekten aus. Die Empfehlungen der EMA begründen sich zumeist auf traditionellem (traditional) oder etabliertem (well-established) Gebrauch. Teilweise liegt auch durch Metaanalysen Evidenz für die Wirksamkeit bestimmter Phytotherapeutika bspw. bei Erkältungen und Husten, sowohl bei Kindern als auch bei Erwachsenen vor. Die vorhandenen Studien sind aber oftmals von geringer Qualität. Weitere hochwertige Studien sind erforderlich, um diese Erkenntnisse zu stärken und das volle Potenzial der Phytotherapie in Therapie und Prävention zu realisieren.

show abstract

“…A systematic review of 34 studies of oral and/or nasal CHMs for acute or chronic rhinosinusitis, without surgery, found improvements in symptoms, sinus imaging and measures of mucociliary clearance [ 43 ]. Another systematic review that included 80 randomised controlled trials (RCTs) of herbal medicines for CRS, mostly from China, reported improvements associated with the herbal medicines, but that study combined studies of CRS without surgery and CRS post-surgery [ 45 ]. A review of 32 RCTs of CHMs following surgery reported benefits for combining CHM nasal irrigations with conventional medications [ 46 ].…”

Section: Introductionmentioning

confidence: 99%

Orally administered Chinese herbal therapy to assist post-surgical recovery for chronic rhinosinusitis—A systematic review and meta-analysis

Cui,

Lin,

May

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

This systematic review and meta-analysis aims to: assess the effectiveness and safety of orally administered Chinese herbal medicines (CHMs) as adjuncts to the post-surgical management of chronic rhinosinusitis (CRS); inform clinicians of the current evidence; identify the best available evidence; and suggest directions for further research. Randomised controlled trials (RCTs) were identified from searches of nine databases plus clinical trial registries. Participants were adults and/or children diagnosed with sinusitis or rhinosinusitis, with or without nasal polyps, who had received surgery. Interventions were CHMs used orally following surgery for CRS as additions to conventional post-surgical management. Controls received conventional post-surgical management without CHMs. Studies reported results for Sino-Nasal Outcome Test (SNOT), visual analogue scales (VAS), Lund-Mackay computed tomography score (LM), Lund-Kennedy endoscopic score (LK), mucociliary transport time (MTT), mucociliary transport rate (MTR), mucociliary clearance (MC) or quality of life (QoL). Twenty-one RCTs were included. All used oral CHMs following functional endoscopic sinus surgery (FESS). The pooled results showed no significant difference between groups for SNOT-20 at the end of treatment (EoT) but there was a significant difference at follow up (FU) in favour of additional CHMs. The VAS for total nasal symptoms (VAS-TNS) showed greater improvements in the CHM groups at EoT and FU. Only FU data were reported for LM which showed greater improvement in the CHM groups. LK showed greater improvements at EoT and FU. The measures of mucociliary transport (MTT, MTR, and MC) each showed significantly greater improvement at EoT in the group that received additional CHMs. No study reported QoL. Adverse events were not serious, but reporting was incomplete. The meta-analyses suggested the addition of oral CHMs to conventional management following FESS may improve recovery. However, most studies were not blinded, and substantial heterogeneity was evident in some meta-analyses. Blinded studies are required to further investigate the roles of oral CHMs in post-surgical recovery. Systematic review registration number: The protocol was registered in PROSPERO (CRD42019119586).

show abstract

Herbal medicine for the treatment of chronic rhinosinusitis: A systematic review and meta-analysis

Cited by 3 publications

References 82 publications

Efficacy and safety of Sanfeng Tongqiao Diwan in the treatment of upper airway cough syndrome: a randomized, double-blind, placebo-controlled clinical study

Efficacy and safety of Sanfeng Tongqiao Diwan in the treatment of upper airway cough syndrome: a randomized, double-blind, placebo-controlled clinical study

Phytotherapie bei akuten Atemwegsinfekten – ein Überblick

Orally administered Chinese herbal therapy to assist post-surgical recovery for chronic rhinosinusitis—A systematic review and meta-analysis

Contact Info

Product

Resources

About