Phytohemagglutinin-Stimulated Immune Response

Kaplan, Marvin S.

doi:10.1001/archsurg.1975.01360160055008

Cited by 9 publications

(3 citation statements)

References 17 publications

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“…When the in vitro blastogenic response of the colon adenocarcinoma patients was compared t o the age-matched controls, the patients' blastogenic response was lower with both recall antigens (PPD, VAR, and MO) and mitogens (PHA and PWM). Thus, these observations are in accordance with other reports relating a decline in cellular immunocompetence with progressive tumor growth (Han, 1973;Han and Sokal, 1970;Sokal and Primikirios, 1961;Han and Takita, 1972;Ducos et al, 1970;Merrin and Han, 1974;Catalona.et al, 1973;Kaplan et al, 1975;Lauder and Bone, 1973).…”

Section: Discussionsupporting

confidence: 93%

“…However, a similar evaluation of patients with nonlymphoid cancer has not produced consistent observations. An impaired lymphocyte response to PHA has been observed in patients with bronchogenic (Han and Takita, 1972;Ducos et al, 1970), squamous cell (Merrin and Han, 1974;Catalona et al, 1973) and colon (Kaplan et al, 1975;Lauder and Bone, 1973) carcinomas, as well as in-patients with sarcomas (Catalona et al, 1973). In contrast, no decline of immunologic function could be detected in patients with carcinoma of the breast until the patients were in the terminal stage of illness (Nemoto et al, 1974).…”

Section: Introductionmentioning

confidence: 99%

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Impaired lymphocyte blastogenic response in patients with colon adenocarcinoma: Effects of disease and age

Goldrosen

Han

Jung

et al. 1977

Journal of Surgical Oncology

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The in vitro blastogenic response of 76 patients with colon adenocarcinoma and 29 age-matched normal healthy volunteers was compared. An age-related decline in cellular immunocompetence was observed in both the patient and control group. Within each age interval, the patients' blastogenic responses were lower than the controls' and the rate of decline of the blastogenic response in the patient group was greater in magnitude, suggesting that their disease state also contributed to loss of cellular immunocompetence. Thus, both increasing age and presence of tumor are factors that contribute to the decline the immunocompetence in patients with colon adenocarcinoma.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Impaired lymphocyte blastogenic response in patients with colon adenocarcinoma: Effects of disease and age

Goldrosen

Han

Jung

et al. 1977

Journal of Surgical Oncology

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“…Despite their toxicological drawbacks, kidney beans ( Phaseolus vulgaris ) containing lectins have several health benefits, if taken carefully. Live human population research and within the laboratory setting investigations demonstrate that the phytohemagglutinins (PHAs) have protective effects against DNA damage [ [72] , [73] , [74] ], and are potent modulators of immune response [ 75 ], cell growth [ 76 , 77 ], and mitosis [ 78 , 79 ], and can cause cancer regression [ [80] , [81] , [82] ]. These results further confirm the importance of bean as a functional food due, in part, to the presence of bioactive lectins [ 83 , 84 ].…”

Section: Discussionmentioning

confidence: 99%

New research highlights: Impact of chronic ingestion of white kidney beans (Phaseolus vulgaris L. var. Beldia) on small-intestinal disaccharidase activity in Wistar rats

Nciri

Cho

2018

Toxicology Reports

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Immune reactivity in patients with colorectal cancer: Assessment of biologic risk by immunoparameters

Wanebo¹,

Rao²,

Attiyeh³

et al. 1980

Cancer

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The concept whether immune reactivity was intrinsically related to risk of recurrence was examined in 307 patients with rectal colon cancer, including 181 patients with primary resectable cancer, 48 patients with advanced primary operable cancer, and 78 patients with recurrence. Immune reactivity was measured by 2,4-dinitrochlorobenzene (DNCB) skin tests (219 patients) and by in vitro immunoparameters (1 10 patients) including lymphocyte levels and lymphocyte stimulation tests with mitogens and antigens. There was a linear depression of immune reactivity as measured by DNCB, phytohemagglutinin (PHA) response, and lymphocyte count with increasing stage of disease (P < -05). Immunity was depressed even in patients with Dukes' A cancer (24% were DNCB negative, 33% had low PHA) and was more depressed in patients with Dukes' Band C lesions (40% were DNCB negative, 30% had low PHA), but was profoundly depressed in patients with advanced primary cancer or recurrence (60% had depression of DNCB, PHA, and lymphocyte counts).Short-term prognosis was examined according to DNCB, lymphocyte count, and mitogen responses in patients with resected Dukes' A, B, and C cancers. There was no correlation of recurrence rates in Dukes' C patients with DNCB, lymphocyte count, or the mitogens PHA, Con A o r pokeweed mitogen (PWM). In contrast, tests with CEA have shown a significant correlation of elevated levels with increased recurrence rates in patients with Dukes' C. There were no correlations of any of the immune tests with recurrence rates in Dukes' A or B, although the follow-up is still short (median 48 months), and the median diseasefree survival has not yet been reached. Only patients with advanced disease (liver metastases) showed correlation of immune responses (PHA and lymphocyte count but not DNCB) with survival, P < .05.

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Phytohemagglutinin-Stimulated Immune Response

Cited by 9 publications

References 17 publications

Impaired lymphocyte blastogenic response in patients with colon adenocarcinoma: Effects of disease and age

Impaired lymphocyte blastogenic response in patients with colon adenocarcinoma: Effects of disease and age

New research highlights: Impact of chronic ingestion of white kidney beans (Phaseolus vulgaris L. var. Beldia) on small-intestinal disaccharidase activity in Wistar rats

Immune reactivity in patients with colorectal cancer: Assessment of biologic risk by immunoparameters

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