Impaired lymphocyte blastogenic response in patients with colon adenocarcinoma: Effects of disease and age

Goldrosen, Martin H.; Han, Tao; Jung, Okhee; Smolev, James K.; Ed, Holyoke

doi:10.1002/jso.2930090304

Cited by 13 publications

(1 citation statement)

References 15 publications

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“…Patients who were free of disease in our present study had significantly higher lymphocyte counts than the patients with only a history of benign breast disease. The group with benign disease was slightly younger, but this should have favored a higher average lymphocyte count [16] so that the small age difference between the groups was probably not a relevant factor. The decrease in absolute lymphocyte counts in patients with metastatic disease may be due to the tumor burden, therapy, or both.…”

Section: Discussionmentioning

confidence: 99%

Enumeration of lymphocytes and their subpopulations identified by bacterial adherence in blood smears of patients with breast tumors

Felix¹,

Katz²,

Teodorescu³

et al. 1981

Journal of Surgical Oncology

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Peripheral blood lymphocyte counts were determined in 57 breast clinic patients. These patients were grouped into four clinical/pathological groups: 18 had benign breast disease, 13 had a history of breast cancer but were free of disease at the time of the study, 7 had a history of breast cancer and were free of disease at the time of the study but were on adjuvant chemotherapy, and 19 had active metastatic breast cancer. Two parameters were investigated in a double blind study: 1) the absolute lymphocyte counts and 2) the percentages of lymphocytes that bound different bacteria as markers of lymphocyte subpopulations in conventionally stained blood smears. A significant reduction in mean lymphocyte counts was demonstrated in patients with advanced disease. A significant increase in these counts was found in patients who were free of disease following surgical treatment alone. The T1T2 cells (our denomination), the subpopulation of cells responsible for specific killing in vitro and for suppression of natural cytotoxic cells, was significantly reduced in patients with advanced disease under treatment. The T/B cell ratio in all groups was the same and within normal range. These observations suggest that the observed decrease in the total lymphocytes is due not only to an overall decrease in all classes of lymphocytes but especially in those responsible for specific cell-mediated reactions. They also show that bacteria can be used as reliable reagents for the identification of lymphocyte subpopulations in blood smears.

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Section: Discussionmentioning

confidence: 99%

Enumeration of lymphocytes and their subpopulations identified by bacterial adherence in blood smears of patients with breast tumors

Felix¹,

Katz²,

Teodorescu³

et al. 1981

Journal of Surgical Oncology

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Immune reactivity in patients with colorectal cancer: Assessment of biologic risk by immunoparameters

Wanebo¹,

Rao²,

Attiyeh³

et al. 1980

Cancer

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The concept whether immune reactivity was intrinsically related to risk of recurrence was examined in 307 patients with rectal colon cancer, including 181 patients with primary resectable cancer, 48 patients with advanced primary operable cancer, and 78 patients with recurrence. Immune reactivity was measured by 2,4-dinitrochlorobenzene (DNCB) skin tests (219 patients) and by in vitro immunoparameters (1 10 patients) including lymphocyte levels and lymphocyte stimulation tests with mitogens and antigens. There was a linear depression of immune reactivity as measured by DNCB, phytohemagglutinin (PHA) response, and lymphocyte count with increasing stage of disease (P < -05). Immunity was depressed even in patients with Dukes' A cancer (24% were DNCB negative, 33% had low PHA) and was more depressed in patients with Dukes' Band C lesions (40% were DNCB negative, 30% had low PHA), but was profoundly depressed in patients with advanced primary cancer or recurrence (60% had depression of DNCB, PHA, and lymphocyte counts).Short-term prognosis was examined according to DNCB, lymphocyte count, and mitogen responses in patients with resected Dukes' A, B, and C cancers. There was no correlation of recurrence rates in Dukes' C patients with DNCB, lymphocyte count, or the mitogens PHA, Con A o r pokeweed mitogen (PWM). In contrast, tests with CEA have shown a significant correlation of elevated levels with increased recurrence rates in patients with Dukes' C. There were no correlations of any of the immune tests with recurrence rates in Dukes' A or B, although the follow-up is still short (median 48 months), and the median diseasefree survival has not yet been reached. Only patients with advanced disease (liver metastases) showed correlation of immune responses (PHA and lymphocyte count but not DNCB) with survival, P < .05.

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Immunocompetence in Cancer Patients

Karavodin¹,

Golub²

1983

Cancer Treatment and Research

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Impaired lymphocyte blastogenic response in patients with colon adenocarcinoma: Effects of disease and age

Cited by 13 publications

References 15 publications

Enumeration of lymphocytes and their subpopulations identified by bacterial adherence in blood smears of patients with breast tumors

Enumeration of lymphocytes and their subpopulations identified by bacterial adherence in blood smears of patients with breast tumors

Immune reactivity in patients with colorectal cancer: Assessment of biologic risk by immunoparameters

Immunocompetence in Cancer Patients

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