Phytoestrogens from Psoralea corylifolia reveal estrogen receptor-subtype selectivity

Isobavachalcone attenuates lipopolysaccharide-induced ICAM-1 expression in brain endothelial cells through blockade of toll-like receptor 4 signaling pathways

“…Isobavachalcone is a prenylated chalcone of the flavonoid family, first isolated from PCL in 1968. Isobavachalcone is known to have a wide spectrum of biological activities including anti-viral (Kim et al, 2014), antibacterial (Kuete and Sandjo, 2012), antioxidant (Haraguchi et al, 2002), antiplatelet (Jantan et al, 2010) and estrogenic (Xin et al, 2010) effects. Isobavachalcone has been shown to induce or enhance the apoptosis of cancer cells (Nishimura et al, 2007;Szliszka et al, 2012) and inhibit tumor promotion in an in vivo two-stage mouse skin carcinogenesis test (Akihisa et al, 2006).…”

In vivo pharmacokinetics of bakuchiol after oral administration of bakuchiol extraction in rat plasma

“…What was more, the extract of Psoralea corylifolia L. mainly containing bakuchiol was used as natural food additive in China and Japan (Ling, 2000). It was indicated that bakuchiol could selectively activate ER␤ (Xin et al, 2010) in our previous research. As we know, activating ER␣ could promote the proliferation of cancerous cells, but activating ER␤ could inhibit the proliferation of cancerous cells.…”

“…In our study, we found that the content in its seeds could reach about 6%. As we known, bakuchiol had a dual action on ER␣ and ER␤, but preferentially activate ER␤; while psoralen and isopsoralen showed selectivity for ER␣ (Xin et al, 2010). It has been reported that ER␣ and ER␤ produced opposite effects in human breast cancer cell (MCF-7) proliferation and tumor formation (Paruthiyil et al, 2004).…”

Effects of bavachin and its regulation of melanin synthesis in A375 cells

“…For adult ovariectomized female-mice, Psoralea coryfolia could not only increase keratinization of vaginal epithelial cells and enhance the weight of the uterus, but it also has an influence on their estrous cycles, which demonstrate the estrogen effects of Psoralea coryfolia (2). Bavachin is one of the classic flavonoid phytoestrogens extracted from Psoralea coryfolia (3)(4)(5). Phytoestrogens are one of the selective estrogen receptor (ER) modulators extracted from plants with a structure similar to estrogen, which may have an important role in the treatment of skin disease as a substitute of estrogen, due to its estrogen-like effects but mild estrogen-like side effects (6).…”