Phytochemicals Investigation on a Tropical Plant, Syzygium cumini from Kattuppalayam, Erode District, Tamil Nadu, South India

Kumar, Ashwani; Ilavarasan, R.; Jayachandran, T.; Decaraman, M.; Aravindhan, P.; Padmanabhan, Neal; Krishnan, M.

doi:10.3923/pjn.2009.83.85

Cited by 132 publications

(47 citation statements)

References 3 publications

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“…Medicinal plants have been documented as having beneficial properties used for the management of various ailments because they have been discovered to contain bioactive compounds called phytochemicals (Fasuyi, 2006) and secondary metabolites that can protect humans against diseases (Kumar et al, 2009). Examples of some documented plants and fruits used in the treatment of anemic conditions are Cocos nuciferia (Benin Republic) (Tchogou et al, 2016), leaves extracts of Tectona grandis (Togo) (Diallo et al, 2008) and Justicia secunda Vahl in Benin (Gbenou et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Haematological and biochemical studies on Justicia carnea leaves extract in phenylhydrazine induced-anemia in albino rats

Onyeabo

Achi

Ekeleme-Egedigwe

et al. 2017

Acta Sci Pol Technol Aliment

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Background. Justicia carnea is a medicinal plant used widely in Nigeria which is reported to have diverse functions, including blood-boosting potential. Aim. The effect of the ethanol extract of Justicea carnea (JC) leaves in phenylhydrazine induced-anemia albino rats on haematological and lipid profile parameters was investigated.Methods. The experimental animals were randomly grouped into five groups of six rats each -group 1 (non--anemic control), group 2 (anemic control), group 3 (500 mg/kg of JC extract), group 4 (1000 mg/kg of JC extract) and group 5 (DMSO control). Phenylhydrazine was administered once at a dose of 80 mg/kg b.w. to induce hemolytic anemia. After 28 days of extract administration, they were humanely sacrificed and the serum collected was used for biochemical analysis. Results. In the acute toxicity study, the LD 50 was found to be above 5000 mg/kg body weight. Packed Cell Volume (PCV) values, Red Blood cell (RBC) and haemoglobin (Hb) concentrations decreased (p < 0.05) significantly after 48 hours of phenylhydrazine induction, but after 28 days of administering extracts of Justicia carnea, PCV values, RBC and Hb increased (p < 0.05) significantly. There were significant (p < 0.05) decreases in cholesterol, triacylglycerol, and LDL cholesterol concentrations in the extract-administered groups (groups 3&4) relative to the anemic control. There was a significant (p < 0.05) increase in HDL-cholesterol concentrations in the extract groups (3&4) relative to the non-anemic control. Conclusion. Extracts of Justicia carnea not only reversed anemic conditions in the phenylhydrazine-induced rats, it also improved the lipid profile, and this may be attributed to its rich phytochemical, nutrient and vitamin composition. Therefore, the findings of the study suggest that J. carnea leaves could be used to manage lipid abnormalities associated with anemia.

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Section: Introductionmentioning

confidence: 99%

Haematological and biochemical studies on Justicia carnea leaves extract in phenylhydrazine induced-anemia in albino rats

Onyeabo

Achi

Ekeleme-Egedigwe

et al. 2017

Acta Sci Pol Technol Aliment

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“…Berkaitan dengan hal tersebut juga telah tim peneliti yang dipimpin oleh Kumar juga menemukan adanya aktivitas antidiabetes dari senyawa yang diisolasi dari biji Eugenia cumini [23] Berdasarkan data pada tabel 3 menunjukkan bahwa aktivitas yang dihasilkan masih lebih rendah (34%) dari obat diabet komersial metformin (37%) walaupun dosis penggunaan masih jauh lebih tinggi hampir 10 kali. Hal ini dapat menunjukkan bahwa fraksi hasil isolasi belum merupakan senyawa murni, karena dari data kromatografi llapis tipis TLC juga menunjukkan jumlah spot lebih dari 1.…”

Section: Aktivitas Anti-hiperglikemik Isolat Ekstrak Metanol Kulit Juwetunclassified

Teknik Kromatografi Kolom Vakum Untuk Pemurnian Senyawa Anti-Hiperglikemik Pada Tanaman Juwet (Eugenia Cumini): Tanaman Obat Tradisional Suku Sasak Lombok

Sukib¹,

Kusmiyati²

2011

J. Pijar MIPA

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(1) Progdi. Kimia FMIPA Unram, Jl. Majapahit No. 62 Mataram (0370) Abstrak : Telah dilakukan penelitian tentang penerapan teknik kromatografi kolom vakum untuk pemisahan senyawa anti-hiperglikemik dalam ekstrak metanol kulit kayu juwet Eugenia cumini. Kondisi pemisahan optimum: fasa pendukung/adsorben silikagel G 60 (63 -200 mm) , F = 3,5 cm, l = 30 cm, laju alir 1 ml per menit, dan komposisi eluen Et-OAc:Me-OH (5 : 5). Penentuan aktivitas anti-hipeglikemik dilakukan dengan menggunakan mencit normal dan diabetes induksi aloksan 50 mg/kg bb, yang terbagi menjadi 3 kelompok, kontrol, pelakuan ekstrak/fraksi, dan obat standar metformin. Sampel darah diambil pada hari ke -0, 1, 2, 4, 6, 8, dan 10 sesaat setelah 1 jam perlakuan. Kadar glukosa darah ditentukan dengan metode orto-toluidin. Hasil yang diperoleh menunjukkan bahwa persentase penurunan kadar glukosa darah mencit setelah 8 hari perlakuan adalah: untuk kontrol normal 0%, kontrol diabetes 4%. Untuk perlakuan ekstrak dengan dosis 300 mg/kg terhadap mencit diabetes terjadi penurunan kadar glukosa darah masingmasing: heksana 9%, DCM 18%, Me-OH 38%. Untuk perlakuan fraksi Et-OAc:Me-OH (5 : 5) dengan dosis 50 mg/kg bb terjadi penurunan sebesar 34%, dan untuk obat pembanding metformin (5mg/kg) sebesar 42%. Kesimpulan yang diperoleh dari penelitian ini adalah bahwa ekstrak metanol dari kulit kayu juwet dan fraksi Et-OAc -Me-OH yang diisolasi dengan teknik kromatografi kolom vakum memiliki aktivitas anti-hiperglikemik. Penurunan kadar glukosa darah mencit diabetes memerlukan waktu sampai 8 hari Kata kunci : Kromatogtafi kolom vakum, Juwet, Anti-hiperglikemik, Glukosa Darah VACUUM COLUMN CHROMATOGRAPHIC TECHNIQUE FOR SEPARATION OF ANTI-HYPERGLYCEMIC COMPOUND ON JUWET (EUGENIA CUMINI). TRADITIONAL MEDICINAL PLANT IN SASAK TRIBE LOMBOKAbstract : Vacuum column chromatography technique has been developed for separation anti-hyper-glycemic compound on methanol extract from juwet Eugenia cumini barks. Optimum condition this method are: the adsorbent is silica , F = 3,5 cm, l = 30 cm, elution time 1 ml menit -1 , and solvent system Et-OAc:Me-OH (5 : 5). Normal and alloxan induced diabetic rats were undertaken to evaluated anti-hyperglycemic activity and divided in to three groups, control, extract/fraction, and standar drug metformin. Blood samples were collected one hour after administration on the day 0, 1, 2, 4, 6, 8, and 10. Blood glucose level was determined by the ortho-toluidine method. Treatment with the extract and fraction was isolated from methanol extract resulted in reduction in blood glucose levels after 8 days: for normal control is 0%, diabetic control is 4%. For treatment with the extract at dose 300 mg/kg to diabetic groups decrease in blood glucose is 9% (extract hexane), 18% (extract dichloro-methane), 38% (extract methanol). For treatment with Et-OAc:Me-OH (5 : 5) fraction at dose 50 mg/kg decrease in blood glucose is 34%, and standard drug metformin at dose 5 mg/kg is 42%.The finding of this study indicated that the methanol extract juwet bark and...

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“…All the extracts were dissolved in dimethyl sulphoxide (DMSO) and were used for the phytochemical analysis for the identification of various classes of chemical compounds alkaloids, carbohydrates, terpenoids, flavonoids, saponins using the standard protocol [11][12][13] .…”

Section: Phytochemical Screeningmentioning

confidence: 99%

Antitubercular activity and phytochemical screening of selected medicinal plants

Kaur¹,

Kaur²

2015

Orient. J. Chem

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Phytochemicals Investigation on a Tropical Plant, Syzygium cumini from Kattuppalayam, Erode District, Tamil Nadu, South India

Cited by 132 publications

References 3 publications

Haematological and biochemical studies on Justicia carnea leaves extract in phenylhydrazine induced-anemia in albino rats

Haematological and biochemical studies on Justicia carnea leaves extract in phenylhydrazine induced-anemia in albino rats

Teknik Kromatografi Kolom Vakum Untuk Pemurnian Senyawa Anti-Hiperglikemik Pada Tanaman Juwet (Eugenia Cumini): Tanaman Obat Tradisional Suku Sasak Lombok

Antitubercular activity and phytochemical screening of selected medicinal plants

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