Phytochemicals as Effective Quorum Quenchers Against Bacterial Communication

Subramaniyan, S.; Divyasree, Sasikumar; Sandhia, G.S.

doi:10.2174/1872208310666160908150943

Cited by 4 publications

(2 citation statements)

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“…Sources of natural QSIs include diverse species of higher plants from all continents. They comprise many medicinal plants, vegetables, and edible fruits [13, 25]. However, the majority of studies deal with plant extracts from which QSI molecules have rarely been isolated.…”

mentioning

confidence: 99%

Phillyrin is an effective inhibitor of quorum sensing with potential as an anti-<i>Pseudomonas aeruginosa</i> infection therapy

Zhou

Zhang

Chu

2019

The Journal of Veterinary Medical Science

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In the present study, we evaluated the antibacterial and anti-quorum sensing qualities of phillyrin. The minimum inhibitory concentration (MIC) of phillyrin with regard to Pseudomonas aeruginosa is 0.5 mg/m l . The production of virulence factors—such as rhamnolipid (>78.69%), pyocyanin (>85.94%), and elastase (>89.95%)—that affect the pathogenicity of the P. aeruginosa strain PAO1 apparently declined in the presence of 0.25 mg/m l phillyrin. Biofilm formation decreased by 84.48%. In a Caenorhabditis elegans–Pseudomonas aeruginosa infection model, diseased worms lived longer (63.33%) in a phillyrin-containing medium than in a drug-free medium, and the drug did not directly kill the pathogen. Therefore, the present work suggests that phillyrin has potential as an antimicrobial agent for the control of infectious pathogens.

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mentioning

confidence: 99%

Phillyrin is an effective inhibitor of quorum sensing with potential as an anti-<i>Pseudomonas aeruginosa</i> infection therapy

Zhou

Zhang

Chu

2019

The Journal of Veterinary Medical Science

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“…cajan leaves, using the multiresistant strain of P . falciparum (K1) and combination of chromatographic techniques, identified cajachalcone (2′,6′-dihydroxy-4-methoxy chalcone) from the ethyl acetate fraction, as one of the biologically active constituents [ 73 ].…”

Section: Medicinal Plants In Nigeria With Antimicrobial Activitiesmentioning

confidence: 99%

Antimicrobial Importance of Medicinal Plants in Nigeria

Ugboko

Nwinyi

Oranusi

et al. 2020

The Scientific World Journal

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Despite the success of antibiotic discovery, infectious diseases remain the second leading source of death worldwide, while the resistance to antibiotics is among the significant problems in the twenty-first century. Medicinal plants are very rich in phytochemicals which can be structurally optimized and processed into new drugs. Nigeria enjoys a diverse collection of medicinal plants, and joint research has ascertained the efficacy of these plants. Plants such as guava (Psidium guajava), ginger (Zingiber officinale), neem (Azadirachta indica), and moringa (Moringa oleifera) have been found to exhibit broad range of antimicrobial activities. Studies on Nigerian plants have shown that they contain alkaloids, polyphenols, terpenes, glycosides, and others with possible therapeutic potentials. The antimicrobial activities of some new compounds such as alloeudesmenol, hanocokinoside, orosunol, and 8-demethylorosunol, identified from medicinal plants in Nigeria, are not yet explored. Further investigation and optimization of these compounds will facilitate the development of new sets of pharmacologically acceptable antimicrobial agents. This review study revealed the efficacy of medicinal plants as an alternative therapy in combating and curtailing the development and survival of multidrug-resistant pathogens coupled with the toxic effects of some antibiotics. Due to enormous therapeutic possibilities buried in medicinal plants, there is a need for more research into unique fingerprints and novel compounds that can provide cure to the neglected tropical diseases (NTDs) of humans and animals facing Africa, especially Nigeria.

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Phenazines as potential biomarkers of Pseudomonas aeruginosa infections: synthesis regulation, pathogenesis and analytical methods for their detection

Vilaplana

Marco

2020

Anal Bioanal Chem

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Phytochemicals as Effective Quorum Quenchers Against Bacterial Communication

Cited by 4 publications

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Phillyrin is an effective inhibitor of quorum sensing with potential as an anti-<i>Pseudomonas aeruginosa</i> infection therapy

Phillyrin is an effective inhibitor of quorum sensing with potential as an anti-<i>Pseudomonas aeruginosa</i> infection therapy

Antimicrobial Importance of Medicinal Plants in Nigeria

Phenazines as potential biomarkers of Pseudomonas aeruginosa infections: synthesis regulation, pathogenesis and analytical methods for their detection

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