Phytochemical screening, antioxidant and antibacterial activities of some commercial extract of propolis

Nascimento, Ticiano Gomes do; Silva, Adriana dos Santos; Constant, Patrícia Beltrão Lessa; Silva, Sâmia Andrícia Souza da; Moura, Maria Aline Barros Fidelis de; Almeida, Clinston Paulino de; Silva, Valdemir da Costa; Wanderley, Amanda Barbosa; Júnior, Irinaldo Diniz Basílio; Escodro, Pierre Barnabé

doi:10.1080/00218839.2017.1412563

Cited by 12 publications

(7 citation statements)

References 46 publications

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“…A species of the Leguminosae family ( Dalbergia ecastophyllum ) is the main botanical source of red propolis found in Brazil. Their constituents are different from other propolis varieties and are important as markers for their identification, such as formononetin, isoliquiritigenin, medicarpine, biochanin A and pinocembrin [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…The propolis is known for its extensive biological activities related to skin healing [ 10 , 11 , 12 , 13 , 14 ], as well as an antioxidant [ 15 , 16 ], antibacterial [ 8 , 9 ], antifungal [ 11 ] and anti-inflammatory activities [ 14 ]. These activities are attributed to phenolic compounds and are considered important for the treatment of wounds.…”

Section: Introductionmentioning

confidence: 99%

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New Insights for Red Propolis of Alagoas—Chemical Constituents, Topical Membrane Formulations and Their Physicochemical and Biological Properties

Silva

Basílio

et al. 2020

Molecules

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The main objectives of this study were to evaluate the chemical constitution and allergenic potential of red propolis extract (RPE). They were evaluated, using high performance liquid chromatography (HPLC) and the release of β-hexosaminidase, respectively. A plethora of biologically active polyphenols and the absence of allergic responses were evinced. RPE inhibited the release of β-hexosaminidase, suggesting that the extract does not stimulate allergic responses. Additionally, the physicochemical properties and antibacterial activity of hydrogel membranes loaded with RPE were analyzed. Bio-polymeric hydrogel membranes (M) were obtained using 5% carboxymethylcellulose (M1 and M2), 1.0% of citric acid (M3) and 10% RPE (for all). Their characterization was performed using thermal analysis, Fourier transform infrared (FTIR), total phenolic content, phenol release test and, antioxidant activity through 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) and Ferric Reducing Antioxidant Power (FRAP). The latter appointed to the similar antioxidant capacity of the M1, M2 and M3. The degradation profiles showed higher thermostability to M3, followed by M2 and M1. The incorporation of RPE into the matrices and the crosslinking of M3 were evinced by FTIR. There were differences in the release of phenolic compounds, with a higher release related to M1 and lower in the strongly crosslinked M3. The degradation profiles showed higher thermostability to M3, followed by M2 and M1. The antibacterial activity of the membranes was determined using the disc diffusion assay, in comparison with controls, obtained in the same way, without RPE. The membranes elicited antibacterial activity against Staphylococcus aureus and Staphylococcus epidermidis, with superior performance over M3. The hydrogel membranes loaded with RPE promote a physical barrier against bacterial skin infections and may be applied in the wound healing process.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

New Insights for Red Propolis of Alagoas—Chemical Constituents, Topical Membrane Formulations and Their Physicochemical and Biological Properties

Silva

Basílio

et al. 2020

Molecules

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“…Propolis is a natural product that has been widely used as a folk medicine all around the world. Antiinflammatory and wound healing potentials and antimicrobial activity of propolis against different microbial strains have been reported [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Characterization of silk sutures coated with propolis and biogenic silver nanoparticles (AgNPs); an eco-friendly solution with wound healing potential against surgical site infections (SSIs)

Baygar

2019

Turk J Med Sci

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Background/aim: Bacterial adherence to a suture material is one of the main causes of surgical site infections. An antibacterial suture material with enhanced wound healing function may protect the surgical site from infections. Thus, the present study aimed to investigate the synergistic effect of propolis and biogenic metallic nanoparticles when combined with silk sutures for biomedical use. Materials and methods: Silver nanoparticle (AgNP) synthesis was carried out via a microbial-mediated biological route and impregnated on propolis-loaded silk sutures using an in situ process. Silk sutures fabricated with propolis and biosynthesized AgNPs (bioAgNP-propolis-coated sutures) were intensively characterized using scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC). The antibacterial characteristics of the bioAgNP-propolis-coated sutures were evaluated using the agar plate method. The biocompatibility of the bioAgNP-propoliscoated sutures was evaluated using 3T3 fibroblast cells, and their wound-healing potential was also investigated. Results: BioAgNP-propolis-coated sutures displayed potent antibacterial activity against pathogenic gram-negative and gram-positive bacteria, Escherichia coli and Staphylococcus aureus, respectively. BioAgNP-propolis-coated silk sutures were found to be biocompatible with 3T3 fibroblast cell culture. In vitro wound healing scratch assay also demonstrated that the extract of bioAgNP-propolis-coated sutures stimulated the 3T3 fibroblasts' cell proliferation. Conclusion: Coating the silk sutures with propolis and biogenic AgNPs gave an effective antibacterial capacity to surgical sutures besides providing biocompatibility and wound healing activity.

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“…With reference to the Brazilian red propolis one of its most exploited biological properties is its antibacterial potential due to its high content of isoflavones, which consist of molecules belonging to the class of flavonoids, whose antimicrobial activity is attributed [45][46][47][48]. Such feature highlights this type of propolis to the development of new therapeutic strategies against bacterial infections if compared to other variants of propolis [49].…”

Section: Introductionmentioning

confidence: 99%

“…The antibacterial activity of Brazilian red propolis has been tested against bacterial agents of clinical relevance such as Staphylococcus aureus [48,50], Streptococcus mutans [51], Enterococcus faecalis [52], E. coli and Pseudomonas aeruginosa [53]. Already suggesting its promising use as a therapeutic target to treat infections concerning both, Gram-positive and Gram-negative bacteria.…”

Section: Introductionmentioning

confidence: 99%

Atividade antibacteriana do extrato etanólico da própolis vermelha brasileira contra bactérias produtoras de β-lactamase e carbapenemase de espectro estendido multidroga-resistentes

Xavier¹,

Silva²,

Soares³

et al. 2023

Sci. Plena

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A própolis é um produto resinoso derivado das abelhas e tem sido amplamente utilizada pela medicina popular ao longo dos anos para diversas finalidades. Um amplo potencial biológico tem sido atribuído ao uso da própolis vermelha brasileira, principalmente sua atividade antimicrobiana, que representa o meio de proteção das abelhas contra patógenos microbianos. Este estudo teve como objetivo avaliar a atividade antibacteriana in vitro do extrato etanólico da própolis vermelha brasileira produzida por Apis mellifera contra bactérias multidroga-resistentes adquiridas em infecções hospitalares. Cinco isolados de Escherichia coli e sete de Klebsiella pneumoniae foram utilizados neste estudo, os quais apresentaram os fenótipos ESBL e/ou KPC. O ensaio antimicrobiano in vitro foi realizado pelo método de microdiluição. As concentrações mínimas inibitórias e bactericidas (CIM e CBM) do extrato etanólico da própolis vermelha foram determinadas para cada cepa bacteriana e exibiu atividade bacteriostática e bactericida contra cepas multidroga-resistentes de E. coli e K. pneumoniae, apresentando a CIM de 2,05 e 0,13 mg/mL e CBM de 15,63 e 3,91 mg/mL, respectivamente. Estes resultados confirmaram a atividade antibacteriana da própolis vermelha brasileira contra cepas multidroga-resistentes, destacando seu uso como um potencial alvo terapêutico para o tratamento adjuvante de infecções bacterianas multidroga-resistentes.

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Phytochemical screening, antioxidant and antibacterial activities of some commercial extract of propolis

Cited by 12 publications

References 46 publications

New Insights for Red Propolis of Alagoas—Chemical Constituents, Topical Membrane Formulations and Their Physicochemical and Biological Properties

New Insights for Red Propolis of Alagoas—Chemical Constituents, Topical Membrane Formulations and Their Physicochemical and Biological Properties

Characterization of silk sutures coated with propolis and biogenic silver nanoparticles (AgNPs); an eco-friendly solution with wound healing potential against surgical site infections (SSIs)

Atividade antibacteriana do extrato etanólico da própolis vermelha brasileira contra bactérias produtoras de β-lactamase e carbapenemase de espectro estendido multidroga-resistentes

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