Phytochemical screening and antimalarial activity of some plants traditionally used in Indonesia

Abdillah, Syamsudin; Tambunan, Risma Marisi; Farida, Yunahara; Sandhiutami, Ni Made Dwi; Dewi, Rita Marleta

doi:10.1016/s2222-1808(15)60814-3

Cited by 41 publications

(28 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Quantitative analysis also showed that B. vulgaris leaf is rich in total phenol (0.91 g ascorbic acid equivalent / 100g dry weight) and total flavonoids (262.08 μg catechin equivalent/ g) (Table 1b). These findings are consistent with the reports of Wele et al, (2017), Abdillah et al, (2015) and Wang et al, (2016). Flavonoids are one of the major antimalarial natural products and have been published to exhibit promising results.…”

Section: Resultssupporting

confidence: 93%

Antimalarial Efficacy and Chemopreventive Capacity of Bamboo Leaf (<i>Bambusa vulgaris</i>) in Malaria Parasitized Mice

Anigboro¹

2018

Journal of Applied Sciences and Environmental Management

View full text Add to dashboard Cite

ABSTRACT:The exploration of natural products for the treatment of malarial has been the main focus of scientists in the past decades. In this research, the phytochemical constituents, antimalarial effect, and chemopreventive capacity of aqueous leaf extract of Bambusa vulgaris in malaria parasitized mice was investigated. A total of 30 male mice, grouped into six (n=5), was used. The results obtained showed that B. vulgaris is rich in flavonoid (262.08 µg CE/g) and phenol (0.91 g AAE/ 100 g). There was significant reduction on the activities of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and Gamma glutarmyl-transferase (GGT) upon treatment as compared with the control groups (P<0.05). Concentration of total bilirubin (TB), direct bilirubin (DB) and serum electrolytes (sodium, calcium, phosphorus and chloride) decreased in treated groups; serum urea, creatinine and uric acid also reduced significantly as against the control groups (P<0.05). The hepatoprotection and renal function restoration observed upon the administration of the plant extract indicate to a far reaching end that B. vulgaris leaf extract would be a promising natural antimalarial product devoid of side effects upon use, especially when administered within the dose range of 100 -200 mg/Kg body weight investigated in this study.

show abstract

Section: Resultssupporting

confidence: 93%

Antimalarial Efficacy and Chemopreventive Capacity of Bamboo Leaf (<i>Bambusa vulgaris</i>) in Malaria Parasitized Mice

Anigboro¹

2018

Journal of Applied Sciences and Environmental Management

View full text Add to dashboard Cite

show abstract

“…Africans use it as wound healing agent against putrescent wound. It has been also reported as antiplasmodiac (6)(7)(8). The another plant being studied in this study was Alhagi maurorum of family Fabaceae.…”

Section: Introductionmentioning

confidence: 82%

In-vitro callus induction and multiplication of inter-nodal explants in plants Dicoma tomentosa and Alhagi maurorum

Dhaniya¹,

Parihar²

2019

J. Drug Delivery Ther.

View full text Add to dashboard Cite

Dicoma tomentosa and Alhagi maurorum are the two medicinal plants with fast in-vitro growth. Both the plants have high economic values. Both the plants were investigated on nodal segments and on leaves. The plants were cultured in five different conditions of medium ranging from MS1- MS5. The hormones were used in these mediums in different concentrations. BAP, NAA, Kinetin, and 2,4 D were use. The MS medium in combination with BAP (2.0 and 2.0mg/ml) with NAA 0.1 mg/ml with kinetin 0.25 mg/ml with 2-4 D were taken, where BAP 1 mg/ml with 2 mg/ml of NAA, BAP 2 mg/ml with 0.5 mg/ml of NAA showed better results with callus growth and root-shoot initiation. The best rooting medium found was MS medium supplemented with IAA and IBA 0.5mg/ each. The culture medium was used in different concentrations for estimation of primary metabolites. Maximum protein and lipid percentage were noticed in leaves of both the plants. It can be concluded that both the studied plants have high medicinal importance and can be used as raw material for industry. Keywords: - Dicoma tomentosa; Alhagi maurorum; Plant hormones; MS media.

show abstract

“…These studies have great relevance for tropical countries, because they contribute to the diffusion of knowledge on alternative methods of controlling diseases caused by parasites such as P. falciparum. The antimalarial activity of M. charantia can be related to the synergistic and antagonistic effects of chemically active metabolites present in the extracts, such as alkaloid, flavonoid, saponin, tannin, quinone, steroid, triterpenoid and coumarine (Abdillah et al, 2015).…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Phytochemical profile and biological activities of Momordica charantia L. (Cucurbitaceae): A review

Oliveira¹,

Costa²,

Bezerra³

et al. 2018

Afr. J. Biotechnol.

View full text Add to dashboard Cite

This study discusses the bioactive composition, supercritical fluid extraction and biological activities of Momordica charantia L. from the last five years. Numerous compounds that have been identified in the extracts of M. charantia, including phytosterols, terpenoids, fatty acids, phenolic compounds, phenolic acids and flavonoids were also discussed. Although, several studies reported the use of organic solvents in the extraction of these compounds, this review emphasized on supercritical fluid extraction (SFE), good selectivity, varied fractions in terms of mass yields and chemical composition obtained, in addition to providing a solvent-free extract. Moreover, the biological effects of M. charantia extracts, including their antidiabetic, neuroprotective, anti-obesogenic, antimalarial, antioxidant, antiinflammatory, antimicrobial and allelopathic activities, were discussed. These biological effects of the extracts of M. charantia can directly affect human health. The findings of this review are important, as they can guide future studies related to obtaining bioactive compounds from M. charantia and its applications.

show abstract

Phytochemical screening and antimalarial activity of some plants traditionally used in Indonesia

Cited by 41 publications

References 10 publications

Antimalarial Efficacy and Chemopreventive Capacity of Bamboo Leaf (<i>Bambusa vulgaris</i>) in Malaria Parasitized Mice

Antimalarial Efficacy and Chemopreventive Capacity of Bamboo Leaf (<i>Bambusa vulgaris</i>) in Malaria Parasitized Mice

In-vitro callus induction and multiplication of inter-nodal explants in plants Dicoma tomentosa and Alhagi maurorum

Phytochemical profile and biological activities of Momordica charantia L. (Cucurbitaceae): A review

Contact Info

Product

Resources

About