Phytochemical Screening and Antidiabetic Activity of Different Leaf Extracts From Lotus (Nelumbo Nucifera Gaertn.) in Streptozotocin Induced Mice

Rumanti, Ruth Mayana; Nainggolan, Marline; Harahap, Urip

doi:10.22159/ajpcr.2017.v10i12.20888

Cited by 4 publications

(4 citation statements)

References 9 publications

(9 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2shows a significant increase in the activity of CuZnSOD in Group 4 (4.60±0.11) and Group 3 (3.60±0.13) as compared to Group 2 (2.16±0.08) in heart. Similarly, the activity of MnSOD in Group 3 (9.39±0.18) and Group 4 (9.13±0 19…”

mentioning

confidence: 83%

See 1 more Smart Citation

Effect of Dillenia Indica L. Against Oxidative Stress-Induced Cardiomyopathy on Alloxan-Induced Diabetes Mice Model

Sahariah

Bora

Syiem

et al. 2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: The aim of the present study is to investigate the antihyperglycemic and antioxidative properties of Dillenia indica fruits.Methods: Aqueous fruit extract and methanolic fruit extract (MFE) were prepared, and preliminary phytochemical screening was carried out. Diabetic mice were prepared with alloxan (150 mg/kg) body weight (b.w.). Antihyperglycemic study of short duration was carried out with doses (150–550) mg/kg b.w. of MFE in diabetic mice. Antioxidant enzymes (superoxide dismutase, catalase, and glutathione reductase) activity assays and histopathological analysis were done in heart tissue of mice.Results: Preliminary phytochemical screening showed that the phytoconstituents were strongly present in the MFE and therefore was considered for further studies. From the antihyperglycemic study, it was found that 350 mg/kg b.w. dose was the most effective in reduction of blood glucose level. A significant increase in the activities of the antioxidant enzymes was observed in the MFE-treated group. From the histopathological studies, it was observed that detrimental effects of oxidative stress were attenuated in the treated group.Conclusion: Concluding the studies, it could be ascertained that D. indica fruits were found to be quite effective in proving its potential against hyperglycemia and oxidative stress, and therefore, the fruits could be considered to be of therapeutic value in diabetes.

show abstract

mentioning

confidence: 83%

“…Phytochemical screening was carried out on both aqueous fruit extract (AFE) and MFE, examining the chemical secondary metabolites of alkaloids, flavonoids, glycosides, tannins, terpenes, and saponins [19][20][21].…”

Section: Phytochemical Screeningmentioning

confidence: 99%

Effect of Dillenia Indica L. Against Oxidative Stress-Induced Cardiomyopathy on Alloxan-Induced Diabetes Mice Model

Sahariah

Bora

Syiem

et al. 2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

show abstract

“…Phytochemical screening were carried out on both AFE and MFE examining the chemical secondary metabolites of alkaloids, flavonoids, glycosides, tannins, terpenes, and saponins [13][14][15].…”

Section: Phytochemical Screeningmentioning

confidence: 99%

Methanolic Flower Extract of Phlogacanthus Thyrsiflorus Nees. Attenuates Diabetic Nephropathy in Alloxan-Induced Diabetic Mice

Bora

Syiem

Bhan

2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objectives: The aim of the present study is to determine the effects of Phlogacanthus thyrsiflorus on hyperglycemia and oxidative stress in kidneys of diabetic mice.Methods: Aqueous flower extract (AFE) and methanolic flower extract (MFE) were prepared. Preliminary phytochemical screenings were carried out. Diabetic mice were prepared by administering alloxan at 150 mg/kg body weight (b.w). The effects of different doses (150–550 mg/kg b.w) of the MFE on hyperglycemia were examined for short-term duration in diabetic mice. Activities of antioxidant enzymes, superoxide dismutase (CuZn-SOD and Mn-SOD), catalase (CAT), and glutathione reductase (GR) were examined under normal, diabetic, and diabetic-treated groups. Histopathological studies were also carried out for the above groups.Results: It has been found that the flavonoids and tannins were strongly present in MFE and further in vivo studies with MFE were carried out. It has been also observed that 250 mg/kg b.w dose of MFE showed significant reduction of blood glucose level. The activities of SOD, CAT, and GR increased in diabetic mice treated with MFE. Histological studies showed that MFE could further halt the damage caused by oxidative stress and reduced tissue injuries in diabetic mice.Conclusion: MFE of P. thyrsiflorus has positive effects in alloxan-induced diabetic mice and could be potential candidate for the detailed molecular studies and management of diabetes.

show abstract

“…is rich in polyphenols and flavonoids, and is popular in China where it acts as a characteristic aquatic economic crop. It has been reported to have various biological activities such as antioxidant [14], immunomodulatory, antiviral [15], and hypoglycemic effects [16]. In most studies, organic solvents, water, microwaves, or ultrasound were mainly used to extract the active ingredients of lotus root.…”

Section: Introductionmentioning

confidence: 99%

Fresh and Browned Lotus Root Extracts Promote Cholesterol Metabolism in FFA-Induced HepG2 Cells through Different Pathways

Zhong

Meng

et al. 2023

Foods

View full text Add to dashboard Cite

Browning of fresh-cut plants is mainly attributed to the enzymatic browning of phenolic compounds induced by polyphenol oxidase (PPO), producing browning products such as anthraquinones, flavanol oxides, and glycosides, which are usually considered to be non-toxic. Could browning bring any benefits on behalf of their bioactivity? Our previous study found that browned lotus root extracts (BLREs) could reduce the cholesterol level in obese mice as fresh lotus root extracts (FLREs) did. This study aimed to compare the mechanisms of FLRE and BLRE on cholesterol metabolism and verify whether the main component’s monomer regulates cholesterol metabolism like the extracts do through in vitro experiments. Extracts and monomeric compounds are applied to HepG2 cells induced by free fatty acids (FFA). Extracellular total cholesterol (TC) and triglyceride (TG) levels were also detected. In addition, RT-PCR and Western blot were used to observe cholesterol metabolism-related gene and protein expression. The in vitro results showed that BLRE and FLRE could reduce TC and TG levels in HepG2 cells. In addition, BLRE suppressed the synthesis of cholesterol. Meanwhile, FLRE promoted the synthesis of bile acid (BA) as well as the clearance and efflux of cholesterol. Furthermore, the main monomers of BLRE also decreased cholesterol synthesis, which is the same as BLRE. In addition, the main monomers of FLRE promoted the synthesis of BAs, similar to FLRE. BLRE and FLRE promote cholesterol metabolism by different pathways.

show abstract

Phytochemical Screening and Antidiabetic Activity of Different Leaf Extracts From Lotus (Nelumbo Nucifera Gaertn.) in Streptozotocin Induced Mice

Cited by 4 publications

References 9 publications

Effect of Dillenia Indica L. Against Oxidative Stress-Induced Cardiomyopathy on Alloxan-Induced Diabetes Mice Model

Effect of Dillenia Indica L. Against Oxidative Stress-Induced Cardiomyopathy on Alloxan-Induced Diabetes Mice Model

Methanolic Flower Extract of Phlogacanthus Thyrsiflorus Nees. Attenuates Diabetic Nephropathy in Alloxan-Induced Diabetic Mice

Fresh and Browned Lotus Root Extracts Promote Cholesterol Metabolism in FFA-Induced HepG2 Cells through Different Pathways

Contact Info

Product

Resources

About