Phytochemical Investigation ofAnaphalis lactea

Ren, Ze; Qi, Huanhuan; Shi, Yan‐Ping

doi:10.1055/s-2008-1074547

Cited by 19 publications

(11 citation statements)

References 15 publications

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“…The 1 H-NMR data (Acetone-d6): 6.38 (brs, H-3), 6.53 (brs, H-5), 5.22 (s, H-8). These spectroscopic data were suitable with those reported in the literature [10].…”

Section: Extraction and Isolationsupporting

confidence: 89%

Chemical constituents of the lichen Roccella sinensis growing in Binh Thuan province

Duong

Bui

2019

Sci. Tech. Dev. J. - Nat. Sci.

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The lichen Roccella sinensis has not been studied chemically. This research described the isolation and elucidation of compounds isolated from the lichen Roccella sinensis collected in Binh Thuan. Phytochemistry investigation of this lichen was carried out by using normal phase silica gel column chromatography and thin-layer chromatography. Six compounds was isolated. Their structures were established by extensively spectroscopic analysis as well as comparison with NMR data in the literatures. They are (+)-D-montagnetol (1), (+)-D-erythrin (2), lecanorin (3), 1-acetylerythritol (4), (E)-nostodione A (5), and 2,4-dihydroxyphthalide (6). This is the first time compounds 3 6 were found in the Roccella genus. Compounds 1, 2, and 6 were evaluated for their cytotoxic activities against HepG2 (liver hepatocellular carcinoma), NCI-H460 (human lung cancer), MCF-7 (human breast cancer), and HeLa (human epithelial cancer) and all of them showed no activity.

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“…The 1 H-NMR data (Acetone-d6): 6.38 (brs, H-3), 6.53 (brs, H-5), 5.22 (s, H-8). These spectroscopic data were suitable with those reported in the literature [10].…”

Section: Extraction and Isolationsupporting

confidence: 89%

Chemical constituents of the lichen Roccella sinensis growing in Binh Thuan province

Duong

Bui

2019

Sci. Tech. Dev. J. - Nat. Sci.

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“…(frs. [1][2][3][4][5][6][7][8][9][10][11][12] and their antifungal activity was tested respectively (Table-1). The active frs.…”

Section: Methodsmentioning

confidence: 99%

“…In traditional Chinese medicine (TCM), A. sinica Hance has long been used by local inhabitants to treat tracheitis and enteritis 2 . Previous phytochemical investigation of Anaphalis revealed the presence of flavonoids [3][4][5][6] , triterpenoids 5 , furobenzopyranones 7,8 , diterpenes, hydroxylactones 9 , kaempferol, tiliroside and quercetin 6 and several species from the genus Anaphalis showed significant bioactivity 10 . However, according to existed literatures, little tremetone derivatives isolated from Anaphalis have been reported until now and the antifungal activity of these compounds from A. sinica Hance has rarely been studied.…”

Section: Introductionmentioning

confidence: 99%

Isolation of an Antifungal Compound from Anaphalis sinica Hance

Yang¹,

Zhou²,

Zhang³

et al. 2013

Asian J. Chem.

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The present investigation was in order to isolate antifungal constituents from Anaphalis sinica Hance, using activity against several phytopathogenic fungi as a lead. Bioactivity guided fractionation of the petroleum ether extract has led to the isolation of a tremetone derivative (compound 1), whose structure had been elucidated as 4,6-dihydroxy-14,14-dimethyltremeton based on extensive 1D and 2D NMR and HR-ESI-MS spectral data. Compound 1 had exhibited excellent antifungal activity against Valsa mali, Elsinoe ampelina and Gibberella saubinetii and the values of their EC50 reached 2.27, 7.18 and 12.30 µg/mL respectively, that was comparable to the commercial fungicide carbendazim, whose EC50 values were 1.60, 33.54 and 6.60 µg/mL respectively.

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“…(Asteraceae) has been commonly used to treat albuminuria, hematuria, acute or chronic nephritis, vaginitis, bronchopneumonia, and gastric ulcer [23]. Anaphalis lactea has long been used for invigorating the circulation of blood and for relieving phlegm and hemostasia [24]. Gentiana siphonantha Maxim., a perennial herb in the Gentianaceae family, has been a traditional Chinese medicine for more than 2000 years for the treatment of rheumatoid arthritis, jaundice hepatitis, constipation, pain, and hypertension [25,26,27].…”

Section: Introductionmentioning

confidence: 99%

Antidermatophyte Activity of the Gentiopicroside-Rich n-Butanol Fraction from Gentiana siphonantha Maxim. Root on a Guinea Pig Model of Dermatophytosis

et al. 2018

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Background:Gentiana siphonantha Maxim. is a traditional medicine for the treatment of rheumarthritis, icterepatitis, pain and hypertension; it is rich in gentiopicroside with anti-inflammatory, antibacterial, and free radical-scavenging activities. This study was to evaluate the antidermatophyte activity of G. siphonantha on a guinea pig model in vitro and in vivo. Material andMethods: The antidermatophyte activities of 10 plants were tested by the broth microdilution method. Fractions and an extract of G. siphonantha were tested against Trichophyton mentagrophytes by the disc diffusion method. The morphological changes of T. mentagrophytes were observed. Component analysis of the n-butanol (n-BuOH) fraction was made by HPLC. Finally, the antifungal activity in an in vivo guinea pig model of dermatophytosis was examined. Results:G. siphonantha had strong antidermatophyte activity with MIC₅₀ values of 32-64 μg/mL. The n-BuOH fraction of G. siphonantha showed the most potent activity compared to the other fractions. After being exposed to the n-BuOH fraction at 80 and 160 μg/mL, the hyphae were distorted and collapsed. Gentiopicroside is the main active ingredient in the n-BuOH fraction of G. siphonantha. The lesion scores of the guinea pig model of dermatophytosis significantly declined in the 10% and 30% extract and positive control groups in comparison with the untreated control group. Periodic acid-Schiff and hematoxylin/eosin staining displayed similar results. Conclusion: The n-BuOH fraction of G. siphonantha demonstrated antidermatophyte efficacy in experimental dermatophytosis.

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Phytochemical Investigation ofAnaphalis lactea

Cited by 19 publications

References 15 publications

Chemical constituents of the lichen Roccella sinensis growing in Binh Thuan province

Chemical constituents of the lichen Roccella sinensis growing in Binh Thuan province

Isolation of an Antifungal Compound from Anaphalis sinica Hance

Antidermatophyte Activity of the Gentiopicroside-Rich n-Butanol Fraction from <b><i>Gentiana siphonantha</i></b> Maxim. Root on a Guinea Pig Model of Dermatophytosis

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