Chemical constituents of the lichen Roccella sinensis growing in Binh Thuan province

Abstract

The lichen Roccella sinensis has not been studied chemically. This research described the isolation and elucidation of compounds isolated from the lichen Roccella sinensis collected in Binh Thuan. Phytochemistry investigation of this lichen was carried out by using normal phase silica gel column chromatography and thin-layer chromatography. Six compounds was isolated. Their structures were established by extensively spectroscopic analysis as well as comparison with NMR data in the literatures. They are (+)-D-montagnetol (1), (+)-D-erythrin (2), lecanorin (3), 1-acetylerythritol (4), (E)-nostodione A (5), and 2,4-dihydroxyphthalide (6). This is the first time compounds 3 6 were found in the Roccella genus. Compounds 1, 2, and 6 were evaluated for their cytotoxic activities against HepG2 (liver hepatocellular carcinoma), NCI-H460 (human lung cancer), MCF-7 (human breast cancer), and HeLa (human epithelial cancer) and all of them showed no activity.

Evaluation of the Antifungal and Antiproliferative Properties of the Lichen Roccella tinctoria DC. Extracts and Main Components

“…Although several lichen-derived compounds have been assessed as potential anticancer agents [ 19 , 20 , 22 ], the investigations into isolated compounds 1 – 3 were limited or lacking. Huy and Bui [ 59 ] isolated compounds 1 and 3 from the lichen Roccella sinensis and showed they were nontoxic in MCF-7 (breast cancer cell line), HeLa (cervical cancer cell line), HepG2 (liver hepatocellular carcinoma cell line), and NCI-H460 (human lung cancer cell line) at a concentration of 100 µg/mL. Accordingly, these substances were nontoxic or low-toxic at the same concentration in A549 and Mz-ChA-1 cells under our experimental conditions.…”

Chemical diversity of five coastal Roccella species from mainland France, the Scattered Islands, and São Tomé and Príncipe

“…About 54 secondary metabolites have been reported for this genus, belonging to several classes of compounds. One can find depsides such as erythrin, lecanoric acid, lepraric acid (Huneck 1967;Huneck & Follmann 1967;Aberhart 1969), as well as their sub-units, the monoaromatic phenols, e.g., beta-orcinol, ethyl orsellinate, and montagnetol (Huneck & Follmann 1968;Aberhart 1969;Parrot et al 2014;Duong et al 2017;Duong & Bui 2018;Mallavadhani & Sudhakar 2018). Aliphatic acids like roccellic acid (Huneck & Follmann 1964) and the chromone 6-hydroxymethyleugenitin (Huneck 1972) have also been reported.…”