Phytochemical compounds and antioxidant activity of Coleus tuberosus flesh and peel on different solvent

Abstract

Three different solvents were used to extract the phytochemical compounds in the peel and flesh of Coleus tuberosus. The results of extraction with different solvents were compared based on the levels of phytochemicals compounds and its antioxidant activity. Extraction of bioactive compounds was done by the maceration method using methanol, ethyl acetate, and chloroform for seven days at a ratio of 1:5 (w/v). Determination of total phenolic contents and flavonoids was conducted via spectrophotometric method. Antioxidant activity was evaluated based on DPPH, peroxide value and TBA value. The results showed that the methanol solvent extracted higher total phenolic and flavonoids compounds than the ethyl acetate and chloroform. The antioxidant activity of methanol extracts was higher compared to ethyl acetate and chloroform extracts for both flesh and peel of C. tuberosus. The extract of the peel of C. tuberosus had antioxidant activity higher compared to the flesh extract with the use of methanol, ethyl acetate or chloroform as solvent. There was a positive and significant correlation between total phenolic and flavonoids content against DPPH and a negative and significant correlation with peroxide and TBA value.

Antioxidative, antiproliferative, and apoptosis effect of Coleus tuberosus flesh and peel ethanol extracts on cervical cancer cell lines

“…As a result, the peel ethanolic extract has higher antioxidant activity than the flesh extract C. tuberosus. The antioxidant activity of the CFEE or CPEE was supported by the presence of biologically active compounds such as oleanolic acid, maslinic acid, ursolic acid, phenol, and flavonoids, with the peel having a higher concentration than the flesh [6,7,21,22]. Ursolic acid, oleanolic acid, maslinic acid, and phytosterols acted as free radical scavengers [23][24][25][26][27][28][29].…”

The Development of Gluten-Eggs Free Cookies as Functional Food

“…Nugraheni et al [7], the existence of the processing stages can increase the levels of Coleus tuberosus resistant starch. Nugraheni et al [8] proved that the food source of carbohydrate consumption, i.e. boiled Coleus tuberosus and Coleus tuberosus flake can lower glucose and lipida profile in the diabetes mellitus mice, as well as influencing the formation of SCFA in the colon.…”

“…This is because the resistant starch in a food can have a positive impact, namely improve insulin sensitivity [6]. Some research shows that resistant starch type 3 may improve glucose and lipids profiles on diabetes mellitus mice due to injection of alloxan [7,8]. Gluten-free flour mix is able to lower the risk of type 1 diabetes mellitus [9,10].…”

“…The repeated heating and cooling process can increase the levels of resistant starch on carbohiydrate materials [13]. Nugraheni et al [7], the existence of the processing stages can increase the levels of Coleus tuberosus resistant starch. Nugraheni et al [8] proved that the food source of carbohydrate consumption, i.e.…”

One‐pot Synthesis of Novel Spirooxindoles as Antibacterial and Antioxidant Agents

“…They are considered as an attractive target to the treatment of brain problem. The antioxidant reagents could capture the free radicals directly, and so they show a great activity as neuro‐protective agents and chemo‐protective agents . Moreover, the spirocyclic compounds have non‐planar chiral structure, and so they have been considered as multifunctional agents in biomolecules.…”