Phytochemical composition, antioxidant and antimicrobial activities of Plecospermum spinosum Trecul.

Annadurai, Pushparaj; Vinothkanna, Annadurai; Ma, Yingfei; Pugazhendhi, Arivalagan; Kandavel, Dhandayuthapani

doi:10.1016/j.procbio.2020.09.031

Cited by 20 publications

(11 citation statements)

References 43 publications

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“…In our results, isolated berries flavonoid morin exhibited strong inhibition of carbohydrate digestive enzymes. Our results were similar to the reported studies on plant extract/fraction that showed strong inhibitory action on both α-amylase and α-glucosidase [ 13 , 39 , 41 ]. On the basis of our previous reported study, E. umbellata could be considered a potential antidiabetic medicinal plant and its berry phytoconstituents and glibenclamide can be good therapeutic agents that sufficiently inhibit the rise in glucose level in streptozotocin induced diabetic rat model by inhibiting the activity of carbohydrate digestive enzymes and minimize the post prandial hyperglycemia [ 13 ].…”

Section: Discussionsupporting

confidence: 92%

“…In recent years, medicinal plants have seemed as potential sources of antioxidants, antidiabetic, antimicrobials, and secondary metabolites for therapeutic interventions, which have opened doors for the development of novel plant-based antibacterial agents [ 38 , 39 ]. However, the problems associated with these antimicrobial drugs are their toxic effects and the resistance shown by microbes against these specific groups of antimicrobial agents.…”

Section: Discussionmentioning

confidence: 99%

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Antioxidants Isolated from Elaeagnus umbellata (Thunb.) Protect against Bacterial Infections and Diabetes in Streptozotocin-Induced Diabetic Rat Model

et al. 2021

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The increase in resistance of microbes against conventional drugs is currently a hot issue, whereas diabetes is another main cause of mortalities encountered throughout the world after cancer and heart attacks. New drug sources in the form of plants are investigated to get effective drugs for the mentioned diseases with minimum side effects. Elaeagnus umbellata Thunb. is a medicinal plant used for the management of stress related disorders like diabetes and other health complications. The active constituents of the chloroform extract derived from E. umbellata berries was isolated by silica gel column chromatography which were identified as morin, phloroglucinol, and 1-hexyl benzene through various spectroscopic techniques (electron ionization mass spectrometry, 1H-NMR, and 13C-NMR spectroscopy). The possible protective effects (antioxidant, antibacterial, and antidiabetic activity) of isolated compounds were evaluated using reported methods. Morin exhibited strong in vitro antiradical potential against DPPH (2,2-diphenyl-1-picrylhydrazyl) and ABTS (2,2′-azinobis-3-ethylbenzothiazoline-6-sulfonic acid) radicals along with prominent antibacterial activities against selected bacterial strains (Escherichia coli, Bacillus cereus, Salmonella typhi, Klebsiella pneumonia, Pseudomonas aeruginosa and Proteus mirabilis). Among the isolated compounds the more potent one (morin) was assessed for its in vivo antidiabetic potential in streptozotocin-induced diabetic rat model. The in vivo effects observed were further confirmed in ex vivo experiments where the effect of isolated compound on antioxidant enzyme like glutathione peroxidase (GPx), total content of reduced glutathione (GSH), % DPPH inhibition, and the lipid peroxidation MDA (Malondialdehyde) level in pancreatic tissues homogenates were evaluated. In vivo morin at tested doses (2, 10, 15, 30 and 50 mg/kg body weight) significantly restored the alterations in the levels of fasting blood glucose level and body weight loss along with significant decrease in levels of cholesterol, triglycerides, low density lipoprotein, HbA1c level, and significantly increased the high-density lipoprotein in diabetic rats. Morin also effectively ameliorated the hepatic enzymes, and renal functions like serum creatinine. Morin significantly increased the antioxidant enzyme like GPx activity, GSH content, and % DPPH inhibition activity, while reduced the lipid peroxidation MDA (malondialdehyde) level in pancreatic tissues homogenates, and modification of histopathological changes in diabetic rats. Morin exhibited high antioxidant, antibacterial, and antidiabetic potentials as compared to phloroglucinol and 1-hexyl benzene, that could, therefore, be considered as a promising therapeutic agent to treat diabetes mellitus and bacterial infections.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Antioxidants Isolated from Elaeagnus umbellata (Thunb.) Protect against Bacterial Infections and Diabetes in Streptozotocin-Induced Diabetic Rat Model

et al. 2021

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“…Além disso, o extrato bruto de um derivado vegetal é uma amostra complexa e, portanto, possui diversos compostos (Annadurai et al, 2021). Então, é possível que no extrato do pequi existam outras substâncias com alto poder redutor/capacidade antioxidante que não fenóis, como vitamina C, ácido gálico, ácido quínico, quercetina e quercetina 3-O-arabinose, já identificados em amostras desta fruta (Brandão, Laca-buendía & Macedo, 2002;Roesler et al, 2008).…”

Section: Discussionunclassified

Determinação da atividade antioxidante e de fenóis totais do pequi (Caryocar brasiliense Camb.)

Denger

Kawano

Paula

et al. 2020

RSD

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Antioxidantes naturais em frutas recebem enorme atenção da comunidade científica mundial devido seu papel na prevenção e no controle de doenças associadas ao estresse oxidativo. O objetivo deste estudo foi avaliar a atividade antioxidante das diferentes concentrações do extrato aquoso obtido da polpa do pequi, utilizando a combinação de diferentes metodologias. A partir de 4 % (g/dL) de tal extrato foi determinada a concentração de compostos fenólicos totais e a análise in vitro do potencial antioxidante pelos ensaios da atividade sequestrante do radical 2,2-difenil-1-picril-hidrazila (DPPH) e poder redutor de metais. Para a avaliação ex vivo, determinou-se em homogeneizado de cérebro de ratos a capacidade de inibição da peroxidação lipídica, estimada pela formação de substâncias reativas ao ácido tiobarbitúrico. O conteúdo fenólico total foi de 2,22 ± 0,045 g de equivalentes de ácido tânico/100 g. O teste de DPPH evidenciou que todas as frações das amostras processadas possuíram atividade em suas diferentes concentrações. Em relação a inibição da peroxidação lipídica, o teste de Tukey mostrou redução dos níveis, existindo diferença significativa (p<0,05) a partir da concentração de 0,02 g/dL. Os resultados ressaltam a importância do consumo de pequi e sugerem que, além do seu alto valor nutricional, apresenta excelentes propriedades bioativas e pode, portanto, ser uma estratégia promissora para o desenvolvimento de novas perspectivas agroindustriais.

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“…TAC assay was carried out according the reported method ( Annadurai et al, 2021 ). The assay mixture contained 300 μL of CM extract and 3000 μL of phosphomolybdate reagent were kept at 95 °C for one and half hours.…”

Section: Methodsmentioning

confidence: 99%

“…The power of the extract to reduce ferric ions was analyzed using the reported method ( Zhang et al, 2020 , Annadurai et al, 2021 ). Acetate buffer of pH 3.6 (300 mM), tripyridyl triazine solution (10.0 mM) and ferric chloride solution (20 mM) were mixed in a 10:1:1 vol ratio to make the FRAP reagent.…”

Section: Methodsmentioning

confidence: 99%

Anti-cholinesterase, anti-inflammatory and antioxidant properties of Combretum micranthum G. Don: Potential implications in neurodegenerative disease

Kpemissi

Kantati

Veerapur

et al. 2023

IBRO Neuroscience Reports

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Phytochemical composition, antioxidant and antimicrobial activities of Plecospermum spinosum Trecul.

Cited by 20 publications

References 43 publications

Antioxidants Isolated from Elaeagnus umbellata (Thunb.) Protect against Bacterial Infections and Diabetes in Streptozotocin-Induced Diabetic Rat Model

Antioxidants Isolated from Elaeagnus umbellata (Thunb.) Protect against Bacterial Infections and Diabetes in Streptozotocin-Induced Diabetic Rat Model

Determinação da atividade antioxidante e de fenóis totais do pequi (Caryocar brasiliense Camb.)

Anti-cholinesterase, anti-inflammatory and antioxidant properties of Combretum micranthum G. Don: Potential implications in neurodegenerative disease

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