Anti-cholinesterase, anti-inflammatory and antioxidant properties of Combretum micranthum G. Don: Potential implications in neurodegenerative disease

Kpemissi, Mabozou; Kantati, Yendubé T.; Veerapur, V. P.; Eklu-Gadégbéku, Kwashie; Hassan, Zurina

doi:10.1016/j.ibneur.2022.12.001

Cited by 8 publications

(12 citation statements)

References 60 publications

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“…Today, there is considerable interest in the application of ingredients from natural sources for the prevention of skin aging [ 36 ]. As a West African “long life” tea, the kinkéliba leaf’s health benefits on glucose-lowering or normalizing blood pressure have been validated both in vitro and in vivo [ 9 , 13 ]. It is worth mentioning that the increased levels of chronic pro-inflammatory cytokines are believed to drive many age-associated conditions, such as type 2 diabetes [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

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Kinkéliba (Combretum micranthum) Leaf Extract Alleviates Skin Inflammation: In Vitro and In Vivo Study

Hu¹,

Simon

Wang

et al. 2023

Molecules

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Kinkéliba (Combretum micranthum, Seh-Haw in Wolof) is a popular bush tea in West African countries. Although the kinkéliba plant’s leaves have been widely consumed for its nutritional and medicinal properties, its benefits on skin health potential have been practically untouched. In human epidermal primary keratinocytes, vitexin and isovitexin-rich kinkéliba extract treatment significantly (p < 0.001) enhanced up to 39.6% of the cell survival rate decreased by UV radiation irritation. The treatment of kinkéliba leaf extracts also reduced the production of UV-induced pro-inflammatory cytokines IL-6 and IL-8 by 57.6% and 42.5%, respectively (p < 0.001), which cause skin redness and skin barrier dysfunction, as well as wrinkles and collagen degradation. The anti-inflammation efficacy of kinkéliba leaf extracts might involve significant inhibition on the levels of cellular reactive oxygen species (ROS) (−70.8%, p < 0.001) and nitrotyrosine (−56.9%, p < 0.05). Further topical applications of kinkéliba leaf extract gel were found to reduce sodium lauryl sulfate (SLS)-induced skin inflammation: at D7, the skin trans-epidermal water loss (TEWL) and skin redness (a* value) were both reduced by 59.81% (p < 0.001) and 22.4% (p < 0.001), compared with D0. In vitro and in vivo data support a new topical application of the kinkéliba leaf as an effective active ingredient for the treatment of skin inflammation, as well as subsequent barrier dysfunction and inflammaging.

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Section: Discussionmentioning

confidence: 99%

“…Kinkéliba’s clinical efficacy also includes normalizing blood pressure and nephroprotection, in recent studies [ 9 , 10 ]. The anti-oxidant and anti-inflammatory effects were examined in cell-free models as well [ 11 , 12 , 13 ]. Therefore, the kinkéliba leaf extract has the great potential to promote health benefits on skin.…”

Section: Introductionmentioning

confidence: 99%

Kinkéliba (Combretum micranthum) Leaf Extract Alleviates Skin Inflammation: In Vitro and In Vivo Study

Hu¹,

Simon

Wang

et al. 2023

Molecules

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“…[39] In addition to choline, Bassene et al (1986) described hydroxystachydrin and stachydrin in leaves. [38] In 2010, new types of piperidine flavan alkaloids (57)(58)(59)(60)(61)(62)(63)(64) were isolated by Welch. [42] Recently, desacetylcolchicine has been described in the leaves.…”

Section: Alkaloidsmentioning

confidence: 99%

“…In an ex vivo neuroprotective model, C. micranthum extract showed substantial inhibition (p < 0.001) of oxidative damage caused by FeCl 2 À AA in brain tissue. [62] Abdullahi et al (2023) studied the effects of aqueous leaf extract on the gastrointestinal smooth muscle of rodents. The extract produced relaxation of isolated rabbit jejunum and guinea pig ileum.…”

Section: Other Activitiesmentioning

confidence: 99%

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Combretum micranthum G. Don (Combretaceae): A Review on Traditional Uses, Phytochemistry, Pharmacology and Toxicology

Tine,

Sene,

Gaye

et al. 2024

Chemistry & Biodiversity

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Combretum micranthum (Combretaceae) is a medicinal plant widely known and used in Africa to treat a variety of conditions such as diabetes, fever, coughs, bronchitis, diarrhea, pain, malaria and liver disorders, among others. Due to its wide traditional use, in this review, published scientific reports on its composition and pharmacological properties were explored by conducting a literature search of databases. To date, 155 organic compounds including 34 flavonoids, 16 phenolic acids, 14 alkaloids, 15 fatty acids, 14 terpenoids/steroids, 24 amino acids, 8 carbohydrate substances and 30 other organic compounds have been identified from this plant. In addition to these organic compounds, 6 minerals (potassium nitrate, calcium, magnesium, potassium, sodium, iron and zinc) have also been reported. In vitro and in vivo studies have shown that these phytochemicals and plant extracts have a wide range of pharmacological potential, including antibacterial, antiviral, antioxidant, antidiabetic, anti‐inflammatory, analgesic, antihypertensive, nephroprotective, hepatoprotective, anxiolytic, anti‐cholinesterase and antidiarrheal activities. Additionally, no harmful effects have been revealed through studies. Thus, this study could constitute a valuable reference for the valorization of C. micranthum in the pharmaceutical industry.

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Bioassay-guided identification of potential Alzheimer’s disease therapeutic agents from Kaempferol-Enriched fraction of Aframomum melegueta seeds using in vitro and chemoinformatics approaches

Chukwuma,

Ezeorba,

Nworah

et al. 2023

Arabian Journal of Chemistry

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Anti-cholinesterase, anti-inflammatory and antioxidant properties of Combretum micranthum G. Don: Potential implications in neurodegenerative disease

Cited by 8 publications

References 60 publications

Kinkéliba (Combretum micranthum) Leaf Extract Alleviates Skin Inflammation: In Vitro and In Vivo Study

Kinkéliba (Combretum micranthum) Leaf Extract Alleviates Skin Inflammation: In Vitro and In Vivo Study

Combretum micranthum G. Don (Combretaceae): A Review on Traditional Uses, Phytochemistry, Pharmacology and Toxicology

Bioassay-guided identification of potential Alzheimer’s disease therapeutic agents from Kaempferol-Enriched fraction of Aframomum melegueta seeds using in vitro and chemoinformatics approaches

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