<i>Combretum micranthum</i> G. Don (Combretaceae): A Review on Traditional Uses, Phytochemistry, Pharmacology and Toxicology

Tine, Yoro; Sene, Madieye; Gaye, Cheikhouna; Diallo, Alioune; Ndiaye, Benjamin; Ndoye, Idrissa; Wele, Alassane

doi:10.1002/cbdv.202301606

Cited by 2 publications

(1 citation statement)

References 56 publications

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“…Combretum micranthum (CM), also known as "kinkeliba," is a shrubby plant native to West Africa, belonging to the Combretaceae family. Its presence is significant in traditional African medicine [1], where it has been utilized for centuries to treat a variety of ailments [2]. This plant is distinguished by its botanical description, diverse chemical properties, and multiple pharmaceutical, medicinal, and cosmetic applications.…”

Section: Introductionmentioning

confidence: 99%

Metabolite Profiling and Molecular Network Shows Kinkeloids as Promoting of Collagen Synthesis from Combretum micranthum

Messaili,

Haggouch,

Bignard

et al. 2024

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Combretum micranthum, a plant native to Africa, has a well-documented traditional use in the treatment of various ailments such as fever, diabetes, and malaria. Its pharmaceutical benefits include nephroprotective, anti-inflammatory, antioxidant, and antimicrobial properties, which were proven. In addition, its potential for cosmetic applications is being explored due to its depigmenting, anti-inflammatory, and UV-damage-repairing properties. This article investigates the molecular composition and new cosmetically relevant biological activity of C. micranthum and enriched fractions to begin the establishment of the structure–activity relationship. Firstly, an extract of C. micranthum was prepared and selected for its overall biological response and then fractionated to obtain simplified molecular fractions. One fraction was particularly enriched in kinkeloids, a specific family of compounds to this species. All the fractions and the crude extract were then tested on biological targets to evaluate and compare their cosmetic activities. Molecular networks were constructed from the UHPLC-MS/HRMS data to better characterize the extract and fractions and to highlight structure–activity relationships. This study highlights the metabolic profiling of a butylene glycol extract of C. micranthum, showing its main chemical families and revealing that the kinkeloids, identified by HRMS and NMR, promote an increase in collagen I synthesis, an interesting cosmetic activity neither previously described for these compounds and neither for C. micranthum extract.

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Section: Introductionmentioning

confidence: 99%

Metabolite Profiling and Molecular Network Shows Kinkeloids as Promoting of Collagen Synthesis from Combretum micranthum

Messaili,

Haggouch,

Bignard

et al. 2024

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Combined full-length transcriptomic and metabolomic analysis reveals the molecular mechanisms underlying nutrients and taste components development in Primulina juliae

Zhang,

Yang,

Liu

et al. 2024

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Background Primulina juliae has recently emerged as a novel functional vegetable, boasting a significant biomass and high calcium content. Various breeding strategies have been employed to the domestication of P. juliae. However, the absence of genome and transcriptome information has hindered the research of mechanisms governing the taste and nutrients in this plant. In this study, we conducted a comprehensive analysis, combining the full-length transcriptomics and metabolomics, to unveil the molecular mechanisms responsible for the development of nutrients and taste components in P. juliae. Results We obtain a high-quality reference transcriptome of P. juliae by combing the PacBio Iso-seq and Illumina sequencing technologies. A total of 58,536 cluster consensus sequences were obtained, including 28,168 complete protein coding transcripts and 8,021 Long Non-coding RNAs. Significant differences were observed in the composition and content of compounds related to nutrients and taste, particularly flavonoids, during the leaf development. Our results showed a decrease in the content of most flavonoids as leaves develop. Malate and succinate accumulated with leaf development, while some sugar metabolites were decreased. Furthermore, we identified the different accumulation of amino acids and fatty acids, which are associated with taste traits. Moreover, our transcriptomic analysis provided a molecular basis for understanding the metabolic variations during leaf development. We identified 4,689 differentially expressed genes in the two developmental stages, and through a comprehensive transcriptome and metabolome analysis, we discovered the key structure genes and transcription factors involved in the pathways. Conclusions This study provides a high-quality reference transcriptome and reveals molecular mechanisms associated with the development of nutrients and taste components in P. juliae. These findings will enhance our understanding of the breeding and utilization of P. juliae as a vegetable.

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Combretum micranthum G. Don (Combretaceae): A Review on Traditional Uses, Phytochemistry, Pharmacology and Toxicology

Cited by 2 publications

References 56 publications

Metabolite Profiling and Molecular Network Shows Kinkeloids as Promoting of Collagen Synthesis from Combretum micranthum

Metabolite Profiling and Molecular Network Shows Kinkeloids as Promoting of Collagen Synthesis from Combretum micranthum

Combined full-length transcriptomic and metabolomic analysis reveals the molecular mechanisms underlying nutrients and taste components development in Primulina juliae

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