Bioassay-guided identification of potential Alzheimer’s disease therapeutic agents from Kaempferol-Enriched fraction of Aframomum melegueta seeds using in vitro and chemoinformatics approaches

Chukwuma, Ifeoma Felicia; Ezeorba, Timothy Prince Chidike; Nworah, Florence Nkechi; Apeh, Victor Onukwube; Khalid, Mohammad; Sweilam, Sherouk Hussein

doi:10.1016/j.arabjc.2023.105089

Cited by 6 publications

(2 citation statements)

References 48 publications

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“…An older study has reported using plant-purified metabolites, Catechin, for fabricating gold nanoparticles of an average size of 50 nm. The study showed the very excellent antiviral properties of the formulation by inhibiting 100% CPE caused by the Japanese encephalitis virus even at a very low concentration of 0.04 to 5.85 μg/ml (Chowdhury et al 2016 ). This is, therefore, evidence that purified phytochemicals may be more productive than crude plant extracts for therapeutic purposes.…”

Section: Therapeutic Applications Of Plant-derived Nanomaterialsmentioning

confidence: 99%

Plant-derived nanomaterials (PDNM): a review on pharmacological potentials against pathogenic microbes, antimicrobial resistance (AMR) and some metabolic diseases

et al. 2023

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Plant-derived nanomaterials (PDNM) have gained significant attention recently due to their potential pharmacological applications against pathogenic microbes, antimicrobial resistance (AMR), and certain metabolic diseases. This review introduces the concept of PDNMs and their unique properties, including their small size, high surface area, and ability to penetrate biological barriers. Besides various methods for synthesizing PDNMs, such as green synthesis techniques that utilize plant extracts and natural compounds, the advantages of using plant-derived materials, such as their biocompatibility, biodegradability, and low toxicity, were elucidated. In addition, it examines the recent and emerging trends in nanomaterials derived from plant approaches to combat antimicrobial resistance and metabolic diseases. The sizes of nanomaterials and their surface areas are vital as they play essential roles in the interactions and relationships between these materials and the biological components or organization. We critically analyze the biomedical applications of nanoparticles which include antibacterial composites for implantable devices and nanosystems to combat antimicrobial resistance, enhance antibiotic delivery, and improve microbial diagnostic/detection systemsIn addition, plant extracts can potentially interfere with metabolic syndrome pathways; hence most nano-formulations can reduce chronic inflammation, insulin resistance, oxidative stress, lipid profile, and antimicrobial resistance. As a result, these innovative plant-based nanosystems may be a promising contender for various pharmacological applications.

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Section: Therapeutic Applications Of Plant-derived Nanomaterialsmentioning

confidence: 99%

Plant-derived nanomaterials (PDNM): a review on pharmacological potentials against pathogenic microbes, antimicrobial resistance (AMR) and some metabolic diseases

et al. 2023

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“…Diabetes mellitus (DM) has been found to be a major cause of β-cell destruction in the liver and kidneys and a major contributor to chronic inflammation and apoptosis in the pancreatic islets. 1,2 Due to a constant breakdown or wearing away of organ tissues, the development of DM is defined by long-term damage that is coupled with enhanced actions that are oxidative or inflammatory, leading to increasingly severe diabetic consequences. 3,4 DM has been identified as one of the largest and most serious health disorders, posing a significant public health threat, according to many reports.…”

Section: Introductionmentioning

confidence: 99%

Unveiling the Anti-Diabetic Potential: A Comparative Study on the Vitamin and Amino Acid Profiles of Bioactive Compounds in Fermented and Raw Tamarind (Tamarindus indica L) Seeds

Nwanna,

Aro,

Ogunsuyi

et al. 2024

Natural Product Communications

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Objectives Previous study have shown that the seeds of the tamarind tree ( Tamarindus indica) have anti-diabetic properties without any evidence on the processing method. This present study was carried out to investigate the effect of fermentation on antioxidant as well as anti-diabetic properties of Tamarind ( Tamarindus indica) seeds. Methods The sample was pulverized after five days of typical fermentation alongside raw sample and examined for its antioxidant and anti-diabetic properties. Antioxidant assays such as FRAP, ABTS, NO, and DPPH were carried out to determine the in-vitro inhibitory effects on diabetes-related enzymes α-amylase and α-glucosidase, while amino acids, proximate and minerals content were carried out. Results The findings revealed that fermentation changed the antioxidant properties of the seed powder. While total phenols and flavonoids decreased, inhibition was observed with α-amylase and α-glucosidase, although raw has higher results. Interestingly, the analysis of 18 amino acids on raw and fermented samples indicated an increase value with fermentation. Moreover, there were elevations in Zn, Mn, K, and vitamins C, D, E, and B1. Conclusion In summary, the study indicates that tamarind fermented seed powder holds promise for exerting anti-diabetic effects, likely due to its rich content of amino acids and vitamins endowed with antioxidant properties.

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Exploring the antioxidant potential of endophytic fungi: a review on methods for extraction and quantification of total antioxidant capacity (TAC)

Asomadu,

Ezeorba,

Ezike

et al. 2024

3 Biotech

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Endophytic fungi have emerged as a significant source of natural products with remarkable bioactivities. Recent research has identified numerous antioxidant molecules among the secondary metabolites of endophytic fungi. These organisms, whether unicellular or micro-multicellular, offer the potential for genetic manipulation to enhance the production of these valuable antioxidant compounds, which hold promise for promoting health, vitality, and various biotechnological applications. In this study, we provide a critical review of methods for extracting, purifying, characterizing, and estimating the total antioxidant capacity (TAC) of endophytic fungi metabolites. While many endophytes produce metabolites similar to those found in plants with established symbiotic associations, we also highlight the existence of novel metabolites with potential scientific interest. Additionally, we discuss how advancements in nanotechnology have opened new avenues for exploring nanoformulations of endophytic metabolites in future studies, offering opportunities for diverse biological and industrial applications.

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Bioassay-guided identification of potential Alzheimer’s disease therapeutic agents from Kaempferol-Enriched fraction of Aframomum melegueta seeds using in vitro and chemoinformatics approaches

Cited by 6 publications

References 48 publications

Plant-derived nanomaterials (PDNM): a review on pharmacological potentials against pathogenic microbes, antimicrobial resistance (AMR) and some metabolic diseases

Plant-derived nanomaterials (PDNM): a review on pharmacological potentials against pathogenic microbes, antimicrobial resistance (AMR) and some metabolic diseases

Unveiling the Anti-Diabetic Potential: A Comparative Study on the Vitamin and Amino Acid Profiles of Bioactive Compounds in Fermented and Raw Tamarind (Tamarindus indica L) Seeds

Exploring the antioxidant potential of endophytic fungi: a review on methods for extraction and quantification of total antioxidant capacity (TAC)

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