Phytochemical characterization and antioxidant activities of the fruit extracts of several Crataegus taxa

Bardakçı, Hilal; Celep, Engin; Gozet, Tuba; Kan, Yüksel; Kırmızıbekmez, Hasan

doi:10.1016/j.sajb.2019.04.012

Cited by 23 publications

(24 citation statements)

References 29 publications

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“…The highest antioxidant activity could be connected with the highest level of total phenolic and flavonoid contents. Many previous studies have proved that there is a positive relationship between the levels of total phenolic and flavonoid contents and antioxidant activity (12,18). There are studies on the antioxidant properties of A. repens and C. monogyna species in the literature.…”

Section: Discussionmentioning

confidence: 99%

“…The genus Crataegus consists of 200 species around the world and represented by 21 species in Turkey. Crataegus (Hawthorn) is known as 'Alıç' in Turkey (12). Crataegus (hawthorn) species are widely used in folk medicine in the therapy of diseases such as congestive heart failure, angina, hypertension, arrhythmia.…”

Section: Introductionmentioning

confidence: 99%

“…Crataegus species have been reported to be used in traditional Chinese medicine to remove blood stasis, improve circulation, treat diarrhea, indigestion, hyperlipidemia, hypertension and abdominal pain; in European traditional medicine in the therapy of heart problems in associated with their antiatherosclerotic, cardiotonic, antispasmodic, and hypotensive properties; in Turkey traditional medicine as a diuretic agent for the treatment of intestinal disorders (13). It has been reported that Crataegus species indicated immunostimulant, radical scavenging, antiviral, anti-lipoperoxidant, antimicrobial, anti-inflammatory, antihyperlipidemic, hepatoprotective, gastroprotective, and hypoglycemic activities in relation to containing phenolic compounds, proanthocyanins, triterpenoids, and flavonoid glycosides (12,14).…”

Section: Introductionmentioning

confidence: 99%

“…, and infusion extracts of C. monogyna in the range of 108.65 and 343.54 mg GAE/g extract. In a different study, total phenolic (361.39±3.78-398.48±0.98 mg GAE/g extract) and flavonoid (13.69±0.51-23.87±2.74 mg QE/g extract) contents of C. orientalis, C. monogyna, C. pontica, C. turcicus, C. rhipidophylla were investigated(12). Cosmulescu et al found contents of 203.01±9.56 mg GAE/100 g FW phenolics and 147.98±7.29 mg QE/100 g FW flavonoids in the methanol extract of C. monogyna…”

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confidence: 99%

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Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species

Deveci¹,

Cayan²,

Karakurt³

et al. 2020

Eur J Biol

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The aim of this study was to investigate antioxidant, enzyme inhibitory and cytotoxic activities of Agropyron repens and Crataegus monogyna methanol extracts with total phenolic and flavonoid contents.Materials and Methods: Total phenolic and flavonoid contents of A. repens and C. monogyna methanol extracts were measured according to Folin Ciocalteu and aluminum nitrate methods, respectively. Antioxidant and enzyme inhibitory activities of the methanol extracts were tested spectrophotometrically. Also, cytotoxic activities of the methanol extracts against DLD-1 and CCD-18Co were investigated by using Alamar Blue assay.Results: C. monogyna methanol extract with the highest total phenolic and flavonoid contents (68.13±0.34 µg GAEs/mg extract and 36.91±0.17 µg QEs/mg extract, respectively) had the best antioxidant activity in β-carotene-linoleic acid (IC 50 : 32.72±0.15 µg/mL), CUPRAC (A 0.50 : 282.69±0.25 µg/mL), DPPH • (IC 50 : 71.69±0.85 µg/mL), and ABTS •+ (IC 50 : 40.43±0.55 µg/ mL) assays. A. repens methanol extract showed the highest effect against AChE (18.73±0.47 %), BChE (37.59±1.07 %), urease (89.18±0.84%), α-glucosidase (6.71±0.23 %), whereas C. monogyna methanol extract showed the highest effect against tyrosinase (30.52±1.00%) and α-amylase (37.24±0.06 %). Also, A. repens (IC 50 : 57.38 µg/mL) and C. monogyna (IC 50 : 54.04 µg/ mL) methanol extracts showed close cytotoxic activity on DLD-1. Conclusion:Antioxidant, cytotoxic, and enzyme inhibitory activities of A. repens and C. monogyna methanol extracts were investigated with total phenolic and flavonoid contents in this study. The results obtained with this study strengthen the potential of the studied plants as a new source for the discovery of antioxidant, cytotoxic, and enzyme inhibitor agents.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species

Deveci¹,

Cayan²,

Karakurt³

et al. 2020

Eur J Biol

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“…Determination of FRAP activity of the samples was accomplished in a 96 well-plate template following the procedure reported earlier by Bardakci et al [ 54 ]. At the beginning of the experiment, FRAP reagent was formed by mixing acetate buffer, ferric-tripyridyltriazine and FeCl 3 ·6H 2 O solutions.…”

Section: Methodsmentioning

confidence: 99%

Influence of In Vitro Human Digestion Simulation on the Phenolics Contents and Biological Activities of the Aqueous Extracts from Turkish Cistus Species

et al. 2021

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Oxidative stress is one of the significant precursors of various metabolic diseases such as diabetes, Parkinson’s disease, cardiovascular diseases, cancer, etc. Various scientific reports have indicated that secondary plant metabolites play an important role in preventing oxidative stress and its harmful effects. In this respect, this study was planned to investigate the phenolic profile and antioxidant and antidiabetic potentials of the aqueous extracts from Turkish Cistus species by employing in vitro methods. In vitro digestion simulation procedure was applied to all extracts to estimate the bioavailability of their phenolic contents. Total phenolic, flavonoid, phenolic acid and proanthocyanidin contents were determined for all phases of digestion. In addition, changes in the quantity of the assigned marker flavonoids (tiliroside, hyperoside and quercitrin) were monitored by High-Performance Thin Layer Chromatography (HPTLC) analysis. The antioxidant activity potentials of the extracts were studied by various methods to reveal their detailed activity profiles. On the other hand, in vitro α-amylase and α-glucosidase enzymes and advanced-glycation end product (AGE) inhibitory activities of the extracts were determined to evaluate the antidiabetic potentials of extracts. The results showed that aqueous extracts obtained from the aerial parts of Turkish Cistus species have rich phenolic contents and potential antioxidant and antidiabetic activities; however, their bioactivity profiles and marker flavonoid concentrations might significantly be affected by human digestion. The results exhibited that total phenolic contents, antioxidant activities and diabetes-related enzyme inhibitions of the bioavailable samples were lower than non-digested samples in all extracts.

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Exploring the potential of phenolic and antioxidant compounds in new Rosaceae fruits

Razola‐Díaz,

Aznar‐Ramos,

Benítez

et al. 2024

J Sci Food Agric

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BackgroundRosaceae fruits have been used in traditional medicine for the prevention and treatment of diseases. However, these fruits are not extensively studied attending to its phenolic composition. Thus, this research focuses on the determination of phenolic compounds by HPLC‐ESI‐TOF‐MS, flavan‐3‐ols by HPLC‐FLD and the antioxidant activity by DPPH, ABTS and FRAP of the fruits of five species of genera Crataegus and Sorbus (Rosaceae).ResultsThere were found a total of 71 phenolic compounds from which 30 were identified in these berries for the first time. Crataegus monogyna and Crataegus laciniata revealed higher total phenolic and flavan‐3‐ol content than the other species and the highest antioxidant activities.ConclusionsTherefore, the evaluated fruits have demonstrated to be important sources of bioactive compounds with huge potential of being used for nutraceutical or food scopes. Additional studies could be needed to evaluate the influence of the different production areas on the phenolic content.This article is protected by copyright. All rights reserved.

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Phytochemical characterization and antioxidant activities of the fruit extracts of several Crataegus taxa

Cited by 23 publications

References 29 publications

Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species

Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species

Influence of In Vitro Human Digestion Simulation on the Phenolics Contents and Biological Activities of the Aqueous Extracts from Turkish Cistus Species

Exploring the potential of phenolic and antioxidant compounds in new Rosaceae fruits

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