Phytochemical and pharmacological studies on Orthosiphon stamineus Benth. (Lamiaceae) hydroalcoholic extracts

Antiproliferative and antiangiogenic effects of flavone eupatorin, an active constituent of chloroform extract of Orthosiphon stamineus leaves

“…Tablets or capsules containing dried leaves are also available as a dietary supplement. For its demonstrated efficacy the extracts from O. stamineus have been more closely examined and the results confirmed its diuretic, uricosuric [3], antioxidant, hepatoprotective [4], antiinflammatory [5] and other properties. Extracts of O. stamineus leaves consist of a wide range of compounds, including flavonoids, terpenoids or organic acids such as rosmarinic or caffeic acid [6].…”

Characterisation of phenolic antioxidants in aqueous extract of Orthosiphon grandiflorus tea by LC–ESI-MS/MS coupled to DPPH assay

“…The major components of O. grandiflorus leaves are the polyphenols such as polymethoxylated flavonoids, sinensetin, eupatorin and the caffeic acid derivatives, rosmarinic acid and 2,3-dicaffeoyltartaric acid (Olah, Radu, Mogos ßan, Hanganu, & Gocan, 2003;Sumaryono, Proksch, Wray, Witte, & Hartmann, 1991). In addition, several diterpenes and oxygenated diterpenes were isolated and reported (Awale, Tezuka, Banskota, & Kadota, 2003;Nguyen, Awale, Tezuka, Chien-Hsiung, & Kadota, 2004;Stampoulis et al, 1999;Tezuka et al, 2000).…”

Determination of flavonoids from Orthosiphon stamineus in plasma using a simple HPLC method with ultraviolet detection

“…Several classes of compounds have been identified in this plant and they included flavonoids, terpenoids, saponins, hexoses, organic acids, caffeic acids derivatives, chromene and myo-inositol [2][3][4][5][6]. Among these compounds, the flavonoids and caffeic acid derivatives were found to possess potential therapeutic properties, as they were shown to exert diuretic and uricosuric actions in rats [6].…”

“…Several classes of compounds have been identified in this plant and they included flavonoids, terpenoids, saponins, hexoses, organic acids, caffeic acids derivatives, chromene and myo-inositol [2][3][4][5][6]. Among these compounds, the flavonoids and caffeic acid derivatives were found to possess potential therapeutic properties, as they were shown to exert diuretic and uricosuric actions in rats [6]. The three main flavonoids found in O. stamineus were sinensitin, eupatorin and 3 -hydroxy-5,6,7,4 -tetramethoxyflavone [2,7,8] and they were also shown to possess cytotoxic [2], antifungal [9] and antioxidant activities [10,11].…”