Antiproliferative and antiangiogenic effects of flavone eupatorin, an active constituent of chloroform extract of Orthosiphon stamineus leaves

Dolečková, Iva; Rárová, Lucie; Grúz, Jiří; Vondrusová, Magdaléna; Strnad, M.; Kryštof, Vladimı́r

doi:10.1016/j.fitote.2012.06.002

Cited by 64 publications

(34 citation statements)

References 30 publications

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“…The healing power of Java Tea plant is because of its great chemical contents (Engku Hasmah, Ahmad Tarmizi, Noor Ismawaty and Abdul Ghani, 2012) and sufficient literature on this remarkable plant claims that it can be used to cure chronic diseases such as Diabetics, High Blood Pressure, Blood Circulation Disorder, Gout and Rheumatism and Kidney Stones (Cicero et al, 2012;Dole ckov a et al, 2012;Mohamed et al, 2013).…”

Section: Herbs Potential In Catalysing Economic Growthmentioning

confidence: 99%

Embracing new agriculture commodity through integration of Java Tea as high Value Herbal crops in solar PV farms

Othman

Ya’acob

Abdul‐Rahim

et al. 2015

Journal of Cleaner Production

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Section: Herbs Potential In Catalysing Economic Growthmentioning

confidence: 99%

Embracing new agriculture commodity through integration of Java Tea as high Value Herbal crops in solar PV farms

Othman

Ya’acob

Abdul‐Rahim

et al. 2015

Journal of Cleaner Production

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“…The activity observed was due to the presence of rosmarinic acid which causes formation of free radicals that act as antioxidant. The leaf extract of O. stamineus has shown to induce apoptosis in cancer cells (Doleckova, 2012). Another study has shown that functional recovery of the liver enzyme profiles in mice exposed to Thioacetamide when treated with the leaf extract (Sun, 2000;Alshawsh, 2011).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial activity of Orthosiphon stamineus towards Staphylococcus aureus and methicilin resistant Stahpylococcus aureus (MRSA)

Nor¹,

Yasin²

2018

JCHPS

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In this study, antibacterial activity of crude extract from Orthosiphon stamineus was analyzed. Extraction through immersing method was performed using methanol and aqueous extraction from whole plant (except root). Spot test and MIC was conducted for both extracts to screen for their antibacterial activity against Staphylococcus aureus and 10 methicillin resistant Staphylococcus aureus (MRSA). No antibacterial activity was observed for all strain tested in the spot test assay. However, observation through MIC test showed that both extracts have antibacterial activity. The aqueous extract showed antibacterial activity in the range of 6.25 mg/mL to 50 mg/mL against S. aureus, MRSA strains (ATCC 4330, TM, WM2, K31, K32, K39, and K52). The antibacterial activity of methanol extract was found to be in the range of 12.5 mg/mL to 50 mg/mL). Methanol extract was found to be more active against S. aureus and 9 MRSA strains (ATCC 4330, BM3, TM, WM2, K31, K32, K39, K52 and K59. The aqueous extract tested on S. aureus has the highest MIC value which is 6.25 mg/mL. In conclusion, O. stamineus was found to have potential as an anti-MRSA agent. Further analysis has to be done in order to develop a novel anti-MRSA drug to combat multiple resistant bacteria.

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“…Myricetin and quercetagetin have been shown to inhibit the activity of PI3Ks (18). Given the high antitumor potential of these compounds, a number of plant extracts rich in flavonoids have been investigated in order to evaluate their anticancer properties (19,20). The low production cost of the plant extracts compared to the pure compounds and the synergistic effects of the natural compounds are the main advantages for using natural extracts (21).…”

Section: Introductionmentioning

confidence: 99%

Anticancer potential of selected Fallopia Adans species

et al. 2015

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Abstract. The aim of the present study was to determine the anticancer potential of three species belonging to the Fallopia genus (Polygonaceae): Fallopia convolvulus (F. convolvulus, Fallopia dumetorum (F. dumetorum) and Fallopia aubertii (F. aubertii). For this purpose, crude extracts were obtained and characterized for their phenolic and flavonoid total content and examined for their anticancer activity on three tumor cell lines: breast cancer (MCF7), colon carcinoma (Caco-2) and cervical cancer (HeLa) cells. The cytotoxic potential of the three species was assessed by MTT assay, cell cycle analysis and by the evaluation of mitochondrial membrane potential (MMP). The acute toxicity of the extracts was evaluated using one in vitro cell model (Vero cells, an African Green monkey kidney cell line) and two invertebrate in vivo models (Daphnia magna and Artemia salina). The highest total phenolic and flavonoid content was found in the F. aubertii flower extracts. The cytotoxic effects of the extracts from F. aubertii and F. convolvulus on all three cell lines were examined at concentrations ranging from 3 to 300 µg/ml. G2/M cell cycle arrest was induced by all the extracts, and a significant increase in the subG1 cell population was observed. The hydroethanolic extract from the flowers of F. aubertii induced cell apoptosis more rapidly than the other extracts. The MMP indicates the involvement of the mitochondria in the induction of apoptosis. A positive correlation between the total phenolic content of the extracts and the IC 50 values against the HeLa cells was also noted. None of the extracts exhibited significantly toxic effects. Considering the antitumor potential of F. aubertii and F. convolvulus, these two species may represent a good source of plant extracts with anticancer properties. IntroductionCancer is the main cause of mortality and morbidity in Europe following cardiovascular diseases and represents the uncontrolled growth and spread of cells that arises from a change in one single cell (1). Each year, millions of individuals are diagnosed with cancer. The disease accounts for the death of approximately 3.5 million individuals annually worldwide (2). It was estimated that only in Europe, in 2012, 3.45 million new cases of cancer were noted, excluding non-melanoma skin cancer, and 1.75 million deaths occurred from cancer (3).Throughout history, plant extracts and their purified active components have been the backbone of cancer chemotherapeutics (4). Additionally, structural analogues have been obtained by molecular modifications of the natural compounds and have reinforced the anticancer arsenal (5). It is estimated that over 70% of anticancer compounds are either natural products, or natural product-derived substances (6). The rich diversity of the chemical structures provided by natural resources offers valuable templates for exploring novel molecular scaffolds and is the most significant source of new drug developments (7).Over the past two decades, flavonoid-rich plant extracts and isolated flav...

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Antiproliferative and antiangiogenic effects of flavone eupatorin, an active constituent of chloroform extract of Orthosiphon stamineus leaves

Cited by 64 publications

References 30 publications

Embracing new agriculture commodity through integration of Java Tea as high Value Herbal crops in solar PV farms

Embracing new agriculture commodity through integration of Java Tea as high Value Herbal crops in solar PV farms

Antibacterial activity of Orthosiphon stamineus towards Staphylococcus aureus and methicilin resistant Stahpylococcus aureus (MRSA)

Anticancer potential of selected Fallopia Adans species

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