Phytochemical and pharmacological studies on the genus Arcangelisia: A mini review

Qian, Cheng; Li, Fangyi; Yan, Xiaohui; He, Jun-Hua; Zhang, Hongmei; Wang, Chunhua; He, Yue; Li, Zheng

doi:10.1016/j.arabjc.2021.103346

Cited by 5 publications

(6 citation statements)

References 52 publications

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“…This is evidenced by a 16.65 mm diameter inhibition zone and a MFC of 40 mg/mL (Setyowati et al, 2014). The extracts' secondary metabolites, which disrupt critical microbial processes such as cell wall formation, protein and nucleic acid synthesis, and metabolic pathways, are primarily responsible for these antimicrobial effects (Cheng et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Comparative analysis of antifungal properties in diverse extracts of Arcangelisia flava (L.)

Agustha,

Fadhillah,

Teruna

et al. 2024

Pharm Educ

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Background: Prolonged fungal infections, specifically those induced by Candida species, underscore the critical need to advance efficacious antifungal treatments. Objective: The present investigation examines the antifungal characteristics of A. flava (L.), emphasising the root extracts of A. flava, which contain abundant secondary metabolites such as berberine. Method: The preparation of root extracts of A. flava utilised solvents of diverse polarities. The antifungal activity of these extracts against C. albicans, C. glabrata, and C. krusei was evaluated. Determining the Minimum Inhibition Concentration (MIC) and Minimum Fungal Concentration (MFC) for these extracts underscores the significance of selecting an appropriate solvent when extracting bioactive compounds. Result: The dichloromethane extract exhibited notable effectiveness, specifically against C albicans and C. krusei, thus highlighting its potential as a highly potent antifungal substance. To develop targeted therapies and gain a more comprehensive understanding of the antifungal properties of these extracts, it is critical to refine and isolate their active constituents, as demonstrated by this study. Conclusion: The findings indicate that A. flava, specifically its dichloromethane extract, may have potential as a reservoir of innovative antifungal compounds. This study makes a valuable contribution to the broader endeavour of incorporating conventional medicinal plants into contemporary pharmacological practices, specifically focusing on their potential to combat fungal infections.

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Section: Discussionmentioning

confidence: 99%

Comparative analysis of antifungal properties in diverse extracts of Arcangelisia flava (L.)

Agustha,

Fadhillah,

Teruna

et al. 2024

Pharm Educ

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“…This study investigated the effectiveness of secondary metabolites obtained from A. flava, specifically palmatine (1) and fibraurin (2), in combating Candida species. The research combined laboratory experiments with computer-based studies.…”

Section: Discussionmentioning

confidence: 99%

“…have been postulated in previous research. Using these compounds makes the development of efficacious antifungal treatments against drug-resistant fungal pathogens feasible [2].…”

Section: Introductionmentioning

confidence: 99%

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Antifungal Potential of Secondary Metabolites Derived from Arcangelisia flava (L.) Merr.: An Analysis of In Silico Enzymatic Inhibition and In Vitro Efficacy against Candida Species

Hendra,

Agustha,

Frimayanti

et al. 2024

Molecules

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Considering the escalating resistance to conventional antifungal medications, it is critical to identify novel compounds that can efficiently counteract this challenge. The purpose of this research was to elucidate the fungicidal properties of secondary metabolites derived from Arcangelisia flava, with a specific focus on their efficacy against Candida species. This study utilized a combination approach comprising laboratory simulations and experiments to discern and evaluate the biologically active constituents present in the dichloromethane extract of A. flava. The in vitro experiments demonstrated that compounds 1 (palmatine) and 2 (fibraurin) exhibited antifungal properties. The compounds exhibited minimum inhibitory concentrations (MICs) ranging from 15.62 to 62.5 µg/mL against Candida sp. Moreover, compound 1 demonstrated a minimum fungicidal concentration (MFC) of 62.5 µg/mL against Candida glabrata and C. krusei. In contrast, compound 2 exhibited an MFC of 125 µg/mL against both Candida species. Based on a molecular docking study, it was shown that compounds 1 and 2 have a binding free energy of −6.6377 and −6.7075 kcal/mol, respectively, which indicates a strong affinity and specificity for fungal enzymatic targets. This study utilized pharmacophore modeling and Density Functional Theory (DFT) simulations to better understand the interaction dynamics and structural properties crucial for antifungal activity. The findings underscore the potential of secondary metabolites derived from A. flava to act as a foundation for creating novel and highly efficient antifungal treatments, specifically targeting fungal diseases resistant to existing treatment methods. Thus, the results regarding these compounds can provide references for the next stage in antifungal drug design. Further investigation is necessary to thoroughly evaluate these natural substances’ clinical feasibility and safety characteristics, which show great potential as antifungal agents.

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“…flava, also known as "yellow wood", has demonstrated pharmacological activity. The Arcangelisia genus contains alkaloids, diterpenoids, and other chemical compounds with antibabesial, antimicrobial, antioxidant, anti-inflammatory, antimalarial, antidiabetic, antitumor, cardiotonic, and antihypertensive activities [9]. The leaves of A. flava contain berberine, flavonoid, and saponin, while the stems contain flavonoid, alkaloid, triterpenoid, and saponin [10][11].…”

Section: Introductionmentioning

confidence: 99%

Xanthine oxidase inhibitory activity of Arcangelisia flava

et al. 2022

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Background: Uric acid is generated from xanthine and hypoxanthine through the action of xanthine oxidase. Yellow wood contains flavonoids that inhibit xanthine oxidase activity. Objective: This study aims to determine the effectiveness of ethanol extracts of the leaves and stems of yellow wood in inhibiting xanthine oxidase. Methods: The leaves and stems of yellow wood were extracted with 96% ethanol. Xanthine oxidase activity was measured using UV Vis spectrophotometry at 293 nm at various doses of extracts, and inhibition was represented as the IC50 value. Control was performed with allopurinol. Results: Leaves and stems of yellow wood extract inhibited xanthine oxidase by 17.56% and 96.85% at 50 ppm, with IC50 values of 174.62 and 30.85, respectively. Conclusion: It demonstrates that stem extracts of yellow wood are more effective than leaves at inhibiting xanthine oxidase, lowering uric acid levels.

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Phytochemical and pharmacological studies on the genus Arcangelisia: A mini review

Cited by 5 publications

References 52 publications

Comparative analysis of antifungal properties in diverse extracts of Arcangelisia flava (L.)

Comparative analysis of antifungal properties in diverse extracts of Arcangelisia flava (L.)

Antifungal Potential of Secondary Metabolites Derived from Arcangelisia flava (L.) Merr.: An Analysis of In Silico Enzymatic Inhibition and In Vitro Efficacy against Candida Species

Xanthine oxidase inhibitory activity of Arcangelisia flava

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