Phytochemical and ethno-pharmacological profile of Desmodium gangeticum (L.) DC.: A review

Bhattacharjee, Atanu; S, Shashidhara; Saha, Santanu

doi:10.7439/ijbr.v4i10.355

Cited by 12 publications

(9 citation statements)

References 27 publications

(13 reference statements)

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“…Significant bioactive phytochemicals of this plant include flavonoids, alkaloids, terpenoids, phenolic compounds, and steroids. Furthermore, D. gangeticum has been documented to display immunomodulatory, antidiabetic, antioxidant, antimicrobial, anti-writhing, anti-inflammatory, renal-protective, antiulcer, hepatoprotective, antileishmanial, wound healing, and cardio-protective properties ( Bhattacharjee et al, 2013 ). In laca mice, the alkaloid-rich fraction of D. gangeticum greatly reversed the scopolamine-induced amnesia at the dosage of 50 mg/kg ( Mahajan et al, 2015 ).…”

Section: List Of Herbs Having Memory and Cognition-enhancing Propertiesmentioning

confidence: 99%

Herbal drugs and natural bioactive products as potential therapeutics: A review on pro-cognitives and brain boosters perspectives

Halder

Anand

Nandy

et al. 2021

Saudi Pharmaceutical Journal

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Memory, one of the most vital aspects of the human brain, is necessary for the effective survival of an individual. ‘Memory’ can be defined in various ways but in an overall view, memory is the retention of the information that the brain grasps. Different factors are responsible for the disbalance in the brain’s hippocampus region and the acetylcholine level, which masters the memory and cognitive functions. Plants are a source of pharmacologically potent drug molecules of high efficacy. Recently herbal medicine has evolved rapidly, gaining great acceptance worldwide due to their natural origin and fewer side effects. In this review, the authors have discussed the mechanisms and pharmacological action of herbal bioactive compounds to boost memory. Moreover, this review presents an update of different herbs and natural products that could act as memory enhancers and how they can be potentially utilized in the near future for the treatment of severe brain disorders. In addition, the authors also discuss the differences in biological activity of the same herb and emphasize the requirement for a higher standardization in cultivation methods and plant processing. The demand for further studies evaluating the interactions of herbal drugs is mentioned.

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Section: List Of Herbs Having Memory and Cognition-enhancing Propertiesmentioning

confidence: 99%

Herbal drugs and natural bioactive products as potential therapeutics: A review on pro-cognitives and brain boosters perspectives

Halder

Anand

Nandy

et al. 2021

Saudi Pharmaceutical Journal

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“…Kidney stones are a potential risk factor for chronic kidney disease. [8,9] The traditional medicine system of India is a rich source of valuable medicinal plant but there is no scientific data reported to establish the activity of these plants. Hence these plant parts need to be evaluated, based on their biological efficacy and chemical constituents for drug development.…”

Section: Abstract a R T I C L E I N F O Impact Of Renal Function Varies Depending On The Stone Componentsmentioning

confidence: 99%

Antiurolithiatic Activity of Natural Constituents Isolated From Aerva Lanata Flowers

Prameela

Nagula

2020

Int. J. Pharm. Sci. Drug Res.

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A well-known traditional herb Aerva lanata, broadly used in India for treatment of different ailments such as urolithiasis. Pashanabheda is used as antiurolithiatic in Ayurveda. In the present study, flowers of A. lanata were selected for isolation of active constituents and screening for in vitro antiurolithiatic potentials, as literature supports that flowers have the highest quantity of natural components when compared with the other parts. Hydroalcoholic (80%-water, 20%-alcohol) extract of A. lanata flowers was prepared and fractionation with different organic solvents.. The two fractions (ethyl acetate and n-butanol) were subjected to isolation of active constituents using column chromatography technique, followed by purification of the isolated constituents by preparative high performance thin layer chromatography (HPTLC)and then the individual components were characterized by IR spectrophotometery. Finally, in vitro antiurolithiatic activity was screened by nucleation and aggregation assay. In the aggregation assay, gradual decrease in the calcium oxalate (CaOx) crystal nucleation as well as growth was observed by light microscopy. The findings of the nucleation assay indicate that phytoconstituents inhibited the crystallization of CaOx in solution. The size and the number of calcium oxalate crystals decreased with increasing concentration of the phytoconstituents. The increasing concentrations of Quercetin and betulin (100, 200, 300, 400 and 500 μg/mL) inhibited the CaOx crystal growth. The isolated quercetin and betulin from A. lanata have shown antiurolithiatic effect by significantly reducing the CaOx crystal growth.

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“…The plant has been reported to exhibit anti-inflammatory, antibacterial, antidiabetic, hepatoprotective, antiulcer, locomotor and wound healing activities. D. gangeticum has been reported to contain alkaloids, flavonoids, steroids and terpenoids 3 .The aqueous extract of Desmodium gangeticum has been shown to reverse scopolamine induced amnesia by decreasing whole brain acetylcholinesterase activity 4 .…”

Section: Introductionmentioning

confidence: 99%

Inhibitory activity of Acetylcholinesterase (AChE) and Antioxidant activity of methanolic extract of Desmodium gangeticum (L.)

Ranjan

Kumari

2016

IJB

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Acetylcholinesterase (AChE) inhibition and antioxidant activity are considered to be highly correlated with Alzheimer's disease treatment. The present study was designed to investigate the antioxidant and acetylcholinesterase inhibitory activity of Desmodium gangeticum L. Properly identified powdered plant material was extracted successively using methanol as a solvent. Acetylcholinesterase inhibitory activity was measured with modified Ellman method at 405 nm and antioxidant activity measured based on 1, 1-diphenyl-2-picrylhydrazil (DPPH) free radical scavenging test at 517 nm. Percentage inhibition for AChE ranged from 28.78±0.12 to 40.83±0.05 whereas DPPH radical scavenging percentage ranged from 24.68±0.72 to 42.22±0.67.

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Phytochemical and ethno-pharmacological profile of Desmodium gangeticum (L.) DC.: A review

Cited by 12 publications

References 27 publications

Herbal drugs and natural bioactive products as potential therapeutics: A review on pro-cognitives and brain boosters perspectives

Herbal drugs and natural bioactive products as potential therapeutics: A review on pro-cognitives and brain boosters perspectives

Antiurolithiatic Activity of Natural Constituents Isolated From Aerva Lanata Flowers

Inhibitory activity of Acetylcholinesterase (AChE) and Antioxidant activity of methanolic extract of Desmodium gangeticum (L.)

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