Phytochemical and antioxidant activity evaluation of the bark of Tampoi (Baccaurea macrocarpa)

Erwin, Erwin; Pusparohmana, Widar R.; Sari, Indah Permata; Hairani, Rita; Usman, Usman

doi:10.12688/f1000research.16643.1

Cited by 9 publications

(10 citation statements)

References 17 publications

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“…The Baccaurea species be inspected contain secondary metabolites, including saponins, flavonoids, alkaloids, phenols, anthocyanins, and carotenoids. 4,5 Research on 6 The Tampoi bark has antioxidant activity, in line with the research 7,8 which states that Tampoi peel extract has antioxidant activity. The methanol extract of the Tampoi fruit peel contains alkaloid compounds, polyphenols, and flavonoids.…”

Section: Introductionsupporting

confidence: 54%

Formulation and Physical Properties Test of Nano Cream Preparation Purified Extract of Kenikir Leaf (Etdk) and Tampoi Fruit Peel Extract (Ekbt)

Rahman

Herdaningsih

2021

JFB

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This research has been conducted under the title "formulation and physical properties test of nano cream preparations purified extract of Kenikir leaf (ETDK) and Tampoi fruit peel extract (EKBT)". This study has formulated a nano cream with a purified extract of Kenikir leaf (ETDK), Tampoi fruit peel extract (EKBT), and a combination of ETDK and EKBT. This study aims to determine the purified extract of Kenikir leaves. The purified extract of Tampoi fruit peel can be formulated as nano cream preparations and to determine the physical parameters (organoleptic test, homogeneity, pH, type of nano cream, spreadability, adhesion, and particle size) for the result of the nano cream. The results of the organoleptic test were described and the physical properties of the nano cream were analyzed by using Excel application. Organoleptic testing of the combination of ETDK and EKBT nano cream formula gave a reddish-white color with an aqueous consistency. The ETDK nano cream formula gave a white bone colour with a watery consistency. In contrast, the nano cream formula with EKBT gave a brownish white colour with a watery consistency. It gives a distinctive smell of extract. The third test of nano cream formulas showed that the physical properties of this nano cream preparation met the standard requirements for physical tests. Test the physical properties that meet the pH requirements, type of nano cream, spreadability, adhesion, and particle size, and all three formulas produced an average particle of less than 300nm.

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Section: Introductionsupporting

confidence: 54%

Formulation and Physical Properties Test of Nano Cream Preparation Purified Extract of Kenikir Leaf (Etdk) and Tampoi Fruit Peel Extract (Ekbt)

Rahman

Herdaningsih

2021

JFB

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“…F1000Research: Dataset 1. Sheet 1, raw data of the results of phytochemical evaluation for alkaloids, flavonoids, phenolics, steroids, triterpenoids, and saponins by observing the changing of colors; Sheet 2, raw data of the observation of the mortality numbers of Artemia salina Leach and calculation of LC 50 value in toxicity test using brine shrimp lethality test; Sheet 3, raw data for antioxidant activity by DPPH method, including the measurement of absorbance using spectrophotometer in triplicate, the calculation of percentage of antioxidant activity, and the value of IC50; Sheet 4, raw data of GC-MS analysis., https://doi.org/10.5256/f1000research.16643.d227222 30…”

Section: Data Availabilitymentioning

confidence: 99%

GC-MS profiling and DPPH radical scavenging activity of the bark of Tampoi (Baccaurea macrocarpa)

et al. 2019

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Background : Tampoi ( Baccaurea macrocarpa) is a tropical rainforest plant that produces edible fruit and is native to Southeast Asia, especially East Kalimantan, Indonesia. Previous research showed that Tampoi potentially can be developed as a drug. It was reported that the extract of Tampoi fruit displayed antioxidant activity, which was correlated with its phenolic and flavonoid substances. There is no information about the antioxidant activity of other parts of this plant, such as the bark, which might also have this kind of activity. Therefore, the aim of this study was to evaluate the phytochemical using GC-MS analysis, toxicity againt Artemia salina, and antioxidant activity with DPPH radical scavenging method of the bark of Tampoi. Methods: The bark of Tampoi was extracted with methanol and concentrated using rotary evaporator to obtain the methanol extract of the bark. Secondary metabolites of this extract was determined using phytochemical analysis. Afterward, the methanol extract was tested for its toxicity using brine shrimp lethality test and antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl method. Results : Phytochemical evaluation results showed that the methanol extract of bark of this plant contains several secondary metabolites including alkaloids, flavonoids, phenolics, steroids, and triterpenoids. The toxicity test displayed no toxic property due to a LC 50 value above 1000 ppm. For antioxidant activity, the result exhibited that the methanol extract of bark of this plant could be categorized as an active extract with IC 50 value of 11.15 ppm. Moreover, based on gas chromatography-mass spectrometer analysis, there are 37 isolated compounds from the bark, one of which is methylparaben, a phenolic predicted to act as an antioxidant. Conclusion: The results obtained in this research demonstrated that the bark of Tampoi ( B. macrocarpa) has potential as an antioxidant.

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“…9,12-octadecadienoic acid, methyl ester (Z, Z) have been showed to be powerful anticancer activity with an IC 50 value of 10.60 ± 1.12 against human lung cancer cell line A549. It has been previously proven that unsaturated fatty acid ester possessed signi cant antioxidant properties [73]. It has also been reported that fatty acid esters are deposited on the lipid layer of cell membrane and mitochondria.…”

Section: Discussionmentioning

confidence: 99%

The Apoptosis-inducing Antiproliferative Activity and Quantitative Phytochemical Profiling of Polyphenol-rich Part of Leea Aequata L. Leaves

Mostofa¹,

Reza²,

Khan³

et al. 2021

Preprint

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Aim/Objectives: Oxidative stress (OS) caused by the accumulation of free radicals in the body triggers many life-threatening diseases, including cancer. Plants are the rich source of safe and effective medicinal compounds like antioxidants that can prevent OS by scavenging free radicals. The aim of this study was to explore the chemical compositions of the methanolic extract of Leea aequata L. leaves possessed the highest antioxidant and cytotoxic activities.Methods and Materials: The Leea aequata leaves (LAL) was extracted with 80% methanol and the crude methanolic extract of LAL (CME) was successively fractionated with petroleum ether, chloroform, ethyl acetate and finally with water to get petroleum ether (PEF), chloroform (CHF), ethyl acetate (EAF) and aqueous (AQF) fraction, respectively. The antioxidant activity was evaluated by the in vitro standard spectrophotometric methods. The MTT colorimetric method was used to measure cytotoxic activity. Apoptosis was measured using fluorescein annexin V-FITC/PI staining method. GC-MS was used to investigate phytochemical compositions.Results: Among the fractions, the highest phenolic and flavonoid-rich fraction was EAF, which contained 267.05± 8.53 mg of gallic acid equivalent (GAE) and 152.98±1.96 mg of catechin equivalent (CAE)/gm of dried extract, respectively. The EAF was found to be the highest antioxidant and reducing power activities. Also, EAF had the strongest free radical scavenging activity with IC50 values of 5.11, 36.54 and 38.96 µg/mL for DPPH, hydroxyl and lipid peroxide free radicals, respectively. Moreover, EAF significantly reduced the HeLa cell proliferation and it was due to the induction of apoptosis of HeLa cells. Furthermore, GC-MS data revealed that EAF contained 17 compounds. Methyl esters of long chain fatty acid were the major chemical constituents. Interestingly, hexadecanoic acid, methyl ester; 9-octadecenoic acid (Z)-, methyl ester; 9,12-octadecadienoic acid, methyl ester (Z, Z) and phenol, 2,4-bis(1,1-dimethylethyl) are known to be antioxidant and cytotoxic. Antioxidant and anti-cancer activity were significantly correlated with the total content of phenolics and flavonoids, suggest that the fractions could be the good source of antioxidant and anti-cancer agents.Conclusion: The EAF of Leea aequata has strong polyphenolic content compared to the other fractions. The cytotoxic and antioxidant activity of Leea aequata were due to the presence of different bioactive compounds.

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Phytochemical and antioxidant activity evaluation of the bark of Tampoi (Baccaurea macrocarpa)

Cited by 9 publications

References 17 publications

Formulation and Physical Properties Test of Nano Cream Preparation Purified Extract of Kenikir Leaf (Etdk) and Tampoi Fruit Peel Extract (Ekbt)

Formulation and Physical Properties Test of Nano Cream Preparation Purified Extract of Kenikir Leaf (Etdk) and Tampoi Fruit Peel Extract (Ekbt)

GC-MS profiling and DPPH radical scavenging activity of the bark of Tampoi (Baccaurea macrocarpa)

The Apoptosis-inducing Antiproliferative Activity and Quantitative Phytochemical Profiling of Polyphenol-rich Part of Leea Aequata L. Leaves

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