Phytochemical analyses, antimicrobial and antioxidant activities of stem bark extracts of Distemonanthus benthamianus H. Baill. and fruit extracts of Solanum torvum Sw. from Gabon

Obiang, Cédric Sima; Misso, Rick Léonid Ngoua Meye; Atome, Guy Roger Ndong; Ondo, Joseph Privat; Engonga, Louis Clément Obame; Emvo, Edouard Nsi

doi:10.4103/2221-1691.259001

Cited by 16 publications

(12 citation statements)

References 5 publications

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“…STF demonstrated moderate to weak antifungal activity against the fluconazole-resistant clinical isolates with MIC ranging from 0.25 to 2.00 mg/mL [ 33 ]. The antifungal activity of STF in this study corroborates the findings of Obiang et al [ 25 ] who showed that the ethanol fruit extract of S . torvum possess antifungal activity against fluconazole-sensitive reference strains (ATCC 10231 and ATCC 90028) and clinical isolates of C .…”

Section: Discussionsupporting

confidence: 92%

Bioactive triterpenoids from Solanum torvum fruits with antifungal, resistance modulatory and anti-biofilm formation activities against fluconazole-resistant candida albicans strains

et al. 2021

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Vulvovaginal candidiasis (VVC) is the second most common vaginal infection that affects women of reproductive age. Its increased occurrence and associated treatment cost coupled to the rise in resistance of the causative pathogen to current antifungal therapies has necessitated the need for the discovery and development of novel effective antifungal agents for the treatment of the disease. We report in this study the anti-Candida albicans activity of Solanum torvum 70% ethanol fruit extract (STF), fractions and some isolated compounds against four (4) fluconazole-resistant strains of C. albicans. We further report on the effect of the isolated compounds on the antifungal activity of fluconazole and voriconazole in the resistant isolates as well as their inhibitory effect on C. albicans biofilm formation. STF was fractionated using n-hexane, chloroform (CHCl3) and ethyl acetate (EtOAc) to obtain four respective major fractions, which were then evaluated for anti-C. albicans activity using the microbroth dilution method. The whole extract and fractions recorded MICs that ranged from 0.25 to 16.00 mg/mL. From the most active fraction, STF- CHCl3 (MIC = 0.25–1.00 mg/mL), four (4) known compounds were isolated as Betulinic acid, 3-oxo-friedelan-20α-oic acid, Sitosterol-3-β-D-glucopyranoside and Oleanolic acid. The compounds demonstrated considerably higher antifungal activity (0.016 to 0.512 mg/mL) than the extract and fractions and caused a concentration-dependent anti-biofilm formation activity. They also increased the sensitivity of the C. albicans isolates to fluconazole. This is the first report of 3-oxo-friedelan-20α-oic acid in the plant as well as the first report of betulinic acid, sitosterol-3-β-D-glucopyranoside and oleanolic acid from the fruits of S. torvum. The present study has demonstrated the anti-C. albicans activity of the constituents of S. torvum ethanol fruit extract and also shown that the constituents possess anti-biofilm formation and resistance modulatory activities against fluconazole-resistant clinical C. albicans isolates.

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Section: Discussionsupporting

confidence: 92%

Bioactive triterpenoids from Solanum torvum fruits with antifungal, resistance modulatory and anti-biofilm formation activities against fluconazole-resistant candida albicans strains

et al. 2021

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“…Antibacterials were considered to be bactericidal, those with MBC / MIC ratios equivalent to 1 or 2 and bacteriostatic if the MBC / MIC ratio was equivalent to 4 or 16 [8,9].…”

Section: Antibacterial Activitymentioning

confidence: 99%

Antimicrobial, antioxidant, anti-inflammatory and cytotoxic study of extracts of Guibourtia tessmanii (harms) J. Léonard from Gabon

et al. 2021

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Background Gabonese flora abounds in a significant reserve of plants in medical matter. Thus, medicinal plants occupy a significant place in African pharmacopeia. Aim of this work was to evaluate the antimicrobial, antioxidant, anti-inflammatory and cytotoxic properties of extracts of Guibourtia tessmanii (Harms) J. Léonard. Methods The test for sensitivity to microorganisms was performed by the diffusion method, while the MICs and MBCs were evaluated by the microdilution technique. Antioxidant tests were performed by scavenging the DPPH and ABTS radicals. Anti-inflammatory activity was determined by protein denaturing and membrane stabilization methods. The cytotoxicity was evaluated on the tadpoles of the green frog. Results The antibacterial activity shows that the Gt F2 fraction and the water-acetone extract produced the greatest inhibitions. The water, water-ethanol and water-acetone extracts exhibited bactericidal effects on the majority of bacteria. In the case of trapping of the DPPH radical, the IC50 values varied from 6.92 ± 0.48 to 16.64 ± 0.20 μg/mL. For the decolouration of ABTS, oxidation was mainly inhibited by the water-acetetone, water-ethanol extracts and some fractions. The water and water-acetone extracts showed good inhibition of denaturation. The hemolysis test confirmed the good activities of the extracts. The lethal test showed that the LC50 drops from 171.37 ± 9.25 to 58.25 ± 7.21 μg/mL after 24 and 96 h of exposure. In tadpoles exposed to 7.81 μg / mL of extracts, the first mortalities (12.5%) were observed on the second day of exposure. From the ninth day, the mortality rate increased (25%) until the 16th day. Conclusion Our results show that Guibourtia tessmanii may be a promising product for the isolations of molecules responsible for biological activities.

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“…It is well established that phytochemical constituents are primarily responsible for the pharmacological effects of individual plants. Plants that contain various types of phytochemicals have a long history of serving people all over the world against various elements (16). In this study, plant fruit samples were subjected for extraction with various organic solvents such as, n-hexane, ethyl acetate, ethanol, and water.…”

Section: Discussionmentioning

confidence: 99%

A search for anti-inflammatory potential of successive extracts from fruits of Solanum pubescens willd.

Ismail¹,

Mahmood²,

Rahman³

2023

Biomedicine

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Introduction and Aim: Solanum pubescens (S. pubescens) is well known for its therapeutic proprieties. The current study aimed to conduct phytochemical analyses of various S. pubescens fruit extracts and search for anti-inflammatory and anti-oxidant activities. Materials and Methods: Qualitative and quantitative phytochemical analyses, In vitro anti-inflammatory and antioxidant activities of Solanum pubescens fruit FHE, FAE1, FAE2, FEE, and FWE extracts at different concentrations (100-500µg/ml) was carried out using standard assays. Results: Phytochemical studies revealed diverse types of phytoconstituents in different extracts. The FEE extract observed to be rich in phenolics, whereas the FAE2 and FAE1extract possessed a significant amount of total flavonoids, while the total tannin was found to be high in FEE. Total alkaloids are found in high amounts in FWE, whereas, FEE extract is rich in saponin and carbohydrates (Table-1). In vitro anti-inflammatory activities at various concentrations of 100-500µg/ml against heat induced hemolysis exhibiting 63.82±0.33%, while inhibition of protein denaturation assay revealed 69.63±0.91% activity. Cyclooxygenase and 5-lipoxygenase inhibitory assays showed significant activity of 65.59±1.46% and 74.32±1.68% respectively. Furthermore, in vitro antioxidant activity in DPPH radical scavenging, nitric oxide radicles (NOR), hydroxyl radicles (OH) and superoxide anion (SOR) radicle scavenging activities revealed 84.19±0.83%, 60.73±0.79%, 68.6±0.97% and 53.87±1.38% of inhibition respectively. Conclusion: S. pubescens extracts are found to be rich in bioactive compounds, confirming their potent anti-inflammatory and antioxidant activities, and hence S. pubescens fruit extracts may serve as novel lead for anti-inflammatory compounds.

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Phytochemical analyses, antimicrobial and antioxidant activities of stem bark extracts of Distemonanthus benthamianus H. Baill. and fruit extracts of Solanum torvum Sw. from Gabon

Cited by 16 publications

References 5 publications

Bioactive triterpenoids from Solanum torvum fruits with antifungal, resistance modulatory and anti-biofilm formation activities against fluconazole-resistant candida albicans strains

Bioactive triterpenoids from Solanum torvum fruits with antifungal, resistance modulatory and anti-biofilm formation activities against fluconazole-resistant candida albicans strains

Antimicrobial, antioxidant, anti-inflammatory and cytotoxic study of extracts of Guibourtia tessmanii (harms) J. Léonard from Gabon

A search for anti-inflammatory potential of successive extracts from fruits of Solanum pubescens willd.

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