Phythochemical screening and anticonvulsant activity of Cymbopogon winterianus Jowitt (Poaceae) leaf essential oil in rodents

Quintans‐Júnior, Lucindo José; Souza, Thaís Teles de; Leite, B.S.; Lessa, Nayanna M.N.; Bonjardim, Leonardo Rigoldi; Santos, Márcio Roberto Viana dos; Alves, Péricles Barreto; Blank, Arie Fitzgerald; Antoniolli, Ângelo Roberto

doi:10.1016/j.phymed.2007.09.018

Cited by 120 publications

(63 citation statements)

References 19 publications

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“…An important approach to discover new medicines is survey of natural products, such as medicinal plants or their secondary metabolites that modulate painful conditions (Baratta et al, 1998;. Previous studies (Bakkali et al, 2008;Quintans-Júnior et al, 2008;Oliveira et al, 2009;Li and Vederas, 2009;Venâncio et al, 2011) have demonstrated that several Ocimum species are used to treat central nervous system (CNS) disorders in various regions of the world, mainly in developing countries, and their analgesic profile is frequently reported. In this study, five clinical pathogens were selected for antibacterial activity, namely, S. aureus, K. pneumoniae, P. aeruginosa, E. coli and Proteus mirabilis.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of anti-bacterial activity and bioactive chemical analysis of Ocimum basilicum using Fourier transform infrared (FT-IR) and gas chromatography-mass spectrometry (GC-MS) techniques

Kadhim¹,

Sosa²,

Hameed³

2016

J. Pharmacognosy Phytother.

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The objective of this research was to determine the chemical composition of aerial parts extract from methanol. The phytochemical compound screened by gas chromatography-mass spectrometry (GC-MS) method. Thirty one bioactive phytochemical compounds were identified in the methanolic extract of Ocimum basilicum. The identification of phytochemical compounds is based on the peak area, retention time molecular weight, molecular formula, MS fragment-ions and pharmacological actions. GC-MS and

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Section: Resultsmentioning

confidence: 99%

Evaluation of anti-bacterial activity and bioactive chemical analysis of Ocimum basilicum using Fourier transform infrared (FT-IR) and gas chromatography-mass spectrometry (GC-MS) techniques

Kadhim¹,

Sosa²,

Hameed³

2016

J. Pharmacognosy Phytother.

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“…Citronellol (8) is a monoterpene found in some plants used in popular medicine with antihypertensive agents, including Cymbopogon citratus (Abegaz et al, 1983), Cymbopogon winterianus (Quintans-Júnior et al, 2008), and Lippia alba (Tavares et al, 2005). Bastos et al (2010) and showed that citronellol, administered intravenously, produced hypotension and tachycardia in conscious rats.…”

Section: Citronellolmentioning

confidence: 99%

Cardiovascular effects of monoterpenes: a review

Santos¹,

Moreira²,

Fraga³

et al. 2011

Rev. bras. farmacogn.

149

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Abstract:The monoterpenes are secondary metabolites of plants. They have various pharmacological properties including antifungal, antibacterial, antioxidant, anticancer, anti-spasmodic, hypotensive, and vasorelaxant. The purpose of this research was to review the cardiovascular effects of monoterpenes. The data in this resarch were collected using the Internet portals Pubmed, Scopus, and ISI Web of Knowledge between the years 1987 and 2010. In the study 33 monoterpenes were included, which were related to each of the thirteen individual words: artery, cardiovascular, heart, myocyte, vasorelaxant, vessel, hypotension, hypotensive, cardiomyocyte, ventricular, vasodilatory, aorta, and aortic. The research utilized 22 articles published mainly in the journals Phytomedicine, Fundamental Clinical Pharmacology, Planta Medica, Life Science, European Journal of Pharmacology, and Brazilian Journal of Medical and Biological Research. Of the 33 monoterpenes studied surveyed, sixteen of them had already been studied for their effects on the cardiovascular system: carvacrol, citronellol, p-cymene, eucalyptol (1,8-cineole), linalool, menthol, myrtenal, myrtenol, α-pinene, rotundifolone (piperitenone oxide), sobrerol, thymol, α-limonene, α-terpinen-4-ol, α-terpineol, and perillyl alcohol. The main effects observed were vasorelaxation, decreased heart rate and blood pressure. This review showed that the monoterpenes may be considered promising agents for prevention or treatment of diseases of the cardiovascular system.

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“…Additionally, monoterpenes and their derivative compounds exhibit several types of pharmacological properties, such as anxiolytic (Silva et al, 2007), antinociceptive (De Sousa et al, 2007b), sedative (Elisabetsky et al, 1995;De Sousa et al, 2006a, 2007a, antidepressant (De Sousa et al, 2006b), and anticonvulsant (Viana et al, 2000;De Sousa et al, 2006c, 2007c. In this regard, citronellal (3,7-dimethyl-6-octen-1-al) as a monoterpene is a major component of the essential oils in various aromatic species, such as Cymbopogon winterianus Jowitt (Java citronella) (Quintans-Júnior et al, 2008), Corymbia citriodora (Hook.) K.D.Hill, and C. nardus L. (Lenardão et al, 2007).…”

Section: Introductionmentioning

confidence: 99%