Physiology: Lymph Flow

Mukherjee, Anish; Hooks, Joshua; Dixon, J. Brandon

doi:10.1007/978-3-319-52423-8_8

Cited by 5 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[1]. The lymphatic vasculature consists of lymphatic capillaries (also called initial lymphatic vessels (LVs)), collecting LVs and valves that work together to keep fluid balance [2,3]. Although they belong to the same system, initial LVs and collecting LVs have different structures, corresponding to their distinct functions [4].…”

Section: Introductionmentioning

confidence: 99%

Lymphangiogenesis and Lymphatic Barrier Dysfunction in Renal Fibrosis

Liu

Chen

2022

IJMS

View full text Add to dashboard Cite

As an integral part of the vascular system, the lymphatic vasculature is essential for tissue fluid homeostasis, nutritional lipid assimilation and immune regulation. The composition of the lymphatic vasculature includes fluid-absorbing initial lymphatic vessels (LVs), transporting collecting vessels and anti-regurgitation valves. Although, in recent decades, research has drastically enlightened our view of LVs, investigations of initial LVs, also known as lymphatic capillaries, have been stagnant due to technical limitations. In the kidney, the lymphatic vasculature mainly presents in the cortex, keeping the local balance of fluid, solutes and immune cells. The contribution of renal LVs to various forms of pathology, especially chronic kidney diseases, has been addressed in previous studies, however with diverging and inconclusive results. In this review, we discuss the most recent advances in the proliferation and permeability of lymphatic capillaries as well as their influencing factors. Novel technologies to visualize and measure LVs function are described. Then, we highlight the role of the lymphatic network in renal fibrosis and the crosstalk between kidney and other organs, such as gut and heart.

show abstract

Section: Introductionmentioning

confidence: 99%

Lymphangiogenesis and Lymphatic Barrier Dysfunction in Renal Fibrosis

Liu

Chen

2022

IJMS

View full text Add to dashboard Cite

show abstract

“…The collecting lymphatic vessels are divided into contractile units called lymphangions, which are separated from each other by valves. The contractions of the lymphangions, in the presence of the valves, enable the unidirectional movement of lymph through the lymphatic network (Mukherjee et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Lymphatic injury alters the contractility and mechanosensitivity of collecting lymphatics to intermittent pneumatic compression

Mukherjee

Nepiyushchikh

Michalaki

et al. 2021

The Journal of Physiology

Self Cite

View full text Add to dashboard Cite

Key points We present the first in vivo evidence that lymphatic contraction can entrain with an external oscillatory mechanical stimulus. Lymphatic injury can alter collecting lymphatic contractility, but not much is known about how its mechanosensitivity to external pressure is affected, which is crucial given the current pressure application methods for treating lymphoedema. We show that oscillatory pressure waves (OPW), akin to intermittent pneumatic compression (IPC) therapy, optimally entrain lymphatic contractility and modulate function depending on the frequency and propagation speed of the OPW. We show that the OPW‐induced entrainment and contractile function in the intact collecting lymphatics are enhanced 28 days after a contralateral lymphatic ligation surgery. The results show that IPC efficacy can be improved through proper selection of OPW parameters, and that collecting lymphatics adapt their function and mechanosensitivity after a contralateral injury, switching their behaviour to a pump‐like configuration that may be more suited to the altered microenvironment. Abstract Intermittent pneumatic compression (IPC) is commonly used to control the swelling due to lymphoedema, possibly modulating the collecting lymphatic function. Lymphoedema causes lymphatic contractile dysfunction, but the consequent alterations in the mechanosensitivity of lymphatics to IPC is not known. In the present work, the spatiotemporally varying oscillatory pressure waves (OPW) generated during IPC were simulated to study the modulation of lymphatic function by OPW under physiological and pathological conditions. OPW with three temporal frequencies and three propagation speeds were applied to rat tail collecting lymphatics. The entrainment of the lymphatics to OPW was significantly higher at a frequency of 0.05 Hz compared with 0.1 Hz and 0.2 Hz (P = 0.0054 and P = 0.014, respectively), but did not depend on the OPW propagation speed. Lymphatic function was significantly higher at a frequency of 0.05 Hz and propagation speed of 2.55 mm/s (P = 0.015). Exogenous nitric oxide was not found to alter OPW‐induced entrainment. A contralateral lymphatic ligation surgery was performed to simulate partial lymphatic injury in rat tails. The intact vessels showed a significant increase in entrainment to OPW, 28 days after ligation (compared with sham) (P = 0.016), with a similar increase in lymphatic transport function (P = 0.0029). The results suggest an enhanced mechanosensitivity of the lymphatics, along with a transition to a pump‐like behaviour, in response to a lymphatic injury. These results enhance our fundamental understanding of how lymphatic mechanosensitivity assists the coordination of lymphatic contractility and how this might be leveraged in IPC therapy.

show abstract

Mechanobiology of Lymphatic Vessels

Mukherjee

Dixon

2021

Vascular Mechanobiology in Physiology and Disease

View full text Add to dashboard Cite

Physiology: Lymph Flow

Cited by 5 publications

References 5 publications

Lymphangiogenesis and Lymphatic Barrier Dysfunction in Renal Fibrosis

Lymphangiogenesis and Lymphatic Barrier Dysfunction in Renal Fibrosis

Lymphatic injury alters the contractility and mechanosensitivity of collecting lymphatics to intermittent pneumatic compression

Mechanobiology of Lymphatic Vessels

Contact Info

Product

Resources

About