2022
DOI: 10.3390/ijms23136970
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Abstract: As an integral part of the vascular system, the lymphatic vasculature is essential for tissue fluid homeostasis, nutritional lipid assimilation and immune regulation. The composition of the lymphatic vasculature includes fluid-absorbing initial lymphatic vessels (LVs), transporting collecting vessels and anti-regurgitation valves. Although, in recent decades, research has drastically enlightened our view of LVs, investigations of initial LVs, also known as lymphatic capillaries, have been stagnant due to techn… Show more

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Cited by 5 publications
(6 citation statements)
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“…[86][87][88][89] Together with soluble factors, tissue stiffening produces pathological vasculature with altered lymph fluid flow characteristics and transmural transport properties that maintain or worsen the disease state. [8][9][10][11]76,77,80] Moreover, increased lymphatic vascularization can promote fibrosis via a positive feedback loop, [12,23,83,[90][91][92] and when rapid lymphangiogenesis occurs, vascular permeability (i.e., barrier function) can increase [21,23,93] and produce leaky, nonfunctional vessels. [29,87,94] Conversely, there are disease states with significant fibrosis (e.g., secondary lymphedema, myocardial edema) and insufficient lymphatic vasculature (i.e., inadequate growth, low number of vessels, low vessel function).…”
Section: Fibrosis Inflammation and Lymphaticsmentioning
confidence: 99%
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“…[86][87][88][89] Together with soluble factors, tissue stiffening produces pathological vasculature with altered lymph fluid flow characteristics and transmural transport properties that maintain or worsen the disease state. [8][9][10][11]76,77,80] Moreover, increased lymphatic vascularization can promote fibrosis via a positive feedback loop, [12,23,83,[90][91][92] and when rapid lymphangiogenesis occurs, vascular permeability (i.e., barrier function) can increase [21,23,93] and produce leaky, nonfunctional vessels. [29,87,94] Conversely, there are disease states with significant fibrosis (e.g., secondary lymphedema, myocardial edema) and insufficient lymphatic vasculature (i.e., inadequate growth, low number of vessels, low vessel function).…”
Section: Fibrosis Inflammation and Lymphaticsmentioning
confidence: 99%
“…[26][27][28] In chronic kidney disease with renal fibrosis, increased lymphangiogenesis helps drain excess fluid, but increased recruitment of dendritic cells to the lymph nodes combined with leaky vessels disrupts the immune response. [10,13] Since inflammation and tissue stiffening can trigger lymphangiogenesis and alter barrier function, [14,16,20,29,30] studies on lymphatic vasculature should consider each of these factors when developing therapeutic strategies. Currently, there are differences in treatment approaches based on the type of lymphatic dysregulation.…”
Section: Introductionmentioning
confidence: 99%
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