Eplerenone reduces lymphangiogenesis in the contralateral kidneys of UUO rats
Juan Hao,
Panpan Qiang,
Lili Fan
et al.
Abstract:Inflammation and fibrosis often occur in the kidney after acute injury, resulting in chronic kidney disease and consequent renal failure. Recent studies have indicated that lymphangiogenesis can drive renal inflammation and fibrosis in injured kidneys. However, whether and how this pathogenesis affects the contralateral kidney remain largely unknown. In our study, we uncovered a mechanism by which the contralateral kidney responded to injury. We found that the activation of mineralocorticoid receptors and the … Show more
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