Physiologische und kolloidchemische Untersuchungen über den Mechanismus der durch Gifte bewirkten Kontraktur quer gestreifter Muskeln

Riesser, Otto; Neuschlosz, S. M.

doi:10.1007/bf01865107

Cited by 77 publications

(3 citation statements)

References 4 publications

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“…for males and 44.5+1.5 for females (Davis, Borrego, and Foldes, 1953 Estimation of SDC and SMC in urine was carried out according to the method of Norton and de Beer (1954). This method is based on the property of acetylcholine (Riesser and Neuschloss, 1921) and similar depolarizing substances (Paton and Zaimis, 1949;Bovet et al, 1949) of causing contraction of amphibian muscle. The sensitivity of this method for SDC-C12 is 0.1 ,ug./ml.…”

Section: Methodsmentioning

confidence: 99%

The Urinary Excretion of Succinyldicholine and Succinylmonocholine in Man*

Foldes

Norton

1954

British Journal of Pharmacology and Chemotherapy

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Section: Methodsmentioning

confidence: 99%

The Urinary Excretion of Succinyldicholine and Succinylmonocholine in Man*

Foldes

Norton

1954

British Journal of Pharmacology and Chemotherapy

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“…The possibilities offered by the present method of obtaining quantitative data employing the entire animal, together with the specificity and precision, make its results superior to the mouse drop-off test, in which the all-or-none response does not permit a satisfactory statistical analysis. A much more satisfactory method than the mouse drop-off test is the frog rectus abdominis bio-assay (Riesser and Neuschloss, 1921) modified by Norton and de Beer (1954). This is extremely sensitive but the present method has a better index of precision (A.)…”

Section: Discussionmentioning

confidence: 99%

“…The assay of curarizing agents has been performed so far in intact animals using an all-or-none response (mouse drop-off test), or in isolated neuromuscular preparations, which give better quantitative data (continuous distribution) (Riesser and Neuschloss, 1921;Norton and de Beer, 1954;Bulbring, 1946). It seemed, therefore, desirable to devise a method that employing the intact animal might at the same time give rise to an adequate dose response curve expressed in a continuous variable.…”

mentioning

confidence: 99%

A New Method for the Biological Assay of Curarizing Agents

Salgado¹

1963

British Journal of Anaesthesia

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A method for the bio-assay of curarizing agents is described. Suxamethonium is injected intravenously into anaesthetized and intubated rats. The response is measured as the time of respiratory depression. Doses ranging from 0.311 to 1.05 p.g/g give rise to linear responses when the time of respiratory depression is plotted against log dose. The assays are performed within this range. High and low doses, both of the standard and unknown, are injected into two animals each. The index of precision is 0.14. Precision, specificity, cheapness and the possibility of a wider use (cholinesterase determination) are emphasized.

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Effects of choline and acetylcholine chloride upon peripheral nerve fibers

Nó

1944

J. Cell. Comp. Physiol.

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SEVEN FIGURESAcetylcholine, a substance which even when employed in minute concentrations, exerts a powerful excitatory action at certain synaptic junctions, is not known to have any action upon the nerve fibers themselves.According to observations made by Riesser ( '21), acetylcholine chloride at a concentration of 0.001% has no excitatory effect upon nerve, and if any, has only a slight excitatory action on muscle; but acetylcholine chloride elicits muscular contraction when it is applied to that region of the muscle where the neuromuscular junctions are located. Evidence was offered by Riesser to show that the excitatory effect of acetylcholine takes place at the neuromuscular junction. At present it is well-known that minute amounts of acetylcholine may elicit muscular contraction when the drug is delivered directly t o the zone of the neuromuscular junction by intra-arterial injection (cf. literature in Brown, '37).With regard to the difference between the action of acetycholine upon ganglionic synapses and that exerted upon preganglionic fibers, an experiment performed by Bronk and his co-workers (Bronk, '39) is particularly valuable. When acetylcholine is added at a concentration of 0.01% to the fluid with which a sympathetic ganglion is being perfused, a powerful discharge of postganglionic impulses results, whereas acetylcholine at even five times that concentration (0.05%) is not capable of initiating impulses in the preganglionic fibers. I n this report the effect of large concentrations of acetylcholine chloride upon the sciatic neme of the bullfrog is described and compared with the effect produced by choline chloride, magnesium chloride, eserine sulphate, and glucose.An analysis of the effect of the test substances has been made: (1) by measuring the demarcation potentials between a 10-mm. long segment of the nerve in contact with a large volume of the test solution, 85

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Physiologische und kolloidchemische Untersuchungen über den Mechanismus der durch Gifte bewirkten Kontraktur quer gestreifter Muskeln

Cited by 77 publications

References 4 publications

The Urinary Excretion of Succinyldicholine and Succinylmonocholine in Man*

The Urinary Excretion of Succinyldicholine and Succinylmonocholine in Man*

A New Method for the Biological Assay of Curarizing Agents

Effects of choline and acetylcholine chloride upon peripheral nerve fibers

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